When Multiple Sclerosis Causes Skin Symptoms

Virtually all symptoms of multiple sclerosis (MS) are a result of the damage MS does to the brain and spinal cord. Damage to sensory pathways in the central nervous system can produce abnormal sensations elsewhere in the body, including the skin, says Barbara Giesser, MD, a multiple sclerosis specialist with Pacific Neuroscience Institute in Santa Monica, California, and professor emeritus of clinical neurology at the David Geffen UCLA School of Medicine in Los Angeles.
These abnormal sensations can include numbness, tingling, pain, and itching, as well as the feeling of insects crawling, water dripping, wetness, pressure, and vibration in particular areas of the body.
Race to Erase MS 2022
Next up video playing in 10 seconds
RELATED: Phantom MS Symptoms
However, these sensations have nothing to do with the skin. Rather, they are due to damage to parts of the brain that receive signals from the nerves that supply sensation to the skin. “Your skin may feel like it’s burning, but you haven’t burned your skin. The nerves are sending the wrong message,” explains Dr. Giesser.
Types of Skin Pain Caused by MS
Most people with MS experience paresthesias, which are abnormal, temporary sensations, including numbness, prickling, or pins and needles, according to the National Institute of Neurological Disorders and Stroke.
Other symptoms include losing feeling on the skin completely (hypoesthesia) and dysesthesias (painful sensations that can affect the legs, feet, arms, and hands), which feel like burning, prickling, stabbing, ice cold, itching, or electrical sensations, notes the National Multiple Sclerosis Society.
RELATED: What You Should Know About MS Complications
Treatments for Skin Pain Caused by MS
Various medications and treatments may help relieve MS-related skin symptoms. These include:
- Antiseizure medications such as carbamazepine (Tegretol), gabapentin (Neurontin), and pregabalin (Lyrica). These work by helping to block the nerves’ ability to transmit painful sensations, explains Giesser.
- Antidepressants such as nortriptyline (Pamelor), amitriptyline (Elavil), and duloxetine (Cymbalta). These work by lowering the nerves' excitability.
- Lidocaine patches to treat severe pain in a localized area.
- Topical creams such as capsaicin cream, which can cause temporary burning or stinging where applied but which can, over time, block painful sensations by blocking the release of a neurotransmitter involved in relaying pain, notes Giesser.
- Acupuncture
- Mindfulness
- Meditation
- Cognitive behavioral therapy (CBT)
If none of these drugs or treatments adequately controls skin pain or discomfort caused by MS, a pain specialist may need to be involved in your care team to offer other alternatives.
RELATED: 9 Surprising Symptoms of MS

Jason Paul Chua, MD, PhD
Medical Reviewer
Jason Chua, MD, PhD, is an assistant professor in the Department of Neurology and Division of Movement Disorders at Johns Hopkins School of Medicine. He received his training at the University of Michigan, where he obtained medical and graduate degrees, then completed a residency in neurology and a combined clinical/research fellowship in movement disorders and neurodegeneration.
Dr. Chua’s primary research interests are in neurodegenerative disease, with a special focus on the cellular housekeeping pathway of autophagy and its impact on disease development in diseases such as Parkinson disease. His work has been supported by multiple research training and career development grants from the National Institute of Neurological Disorders and Stroke and the American Academy of Neurology. He is the primary or coauthor of 14 peer-reviewed scientific publications and two peer-reviewed online learning modules from the American Academy of Neurology. He is also a contributing author to The Little Black Book of Neurology by Osama Zaldat, MD and Alan Lerner, MD, and has peer reviewed for the scientific journals Autophagy, eLife, and Neurobiology of Disease.

Cathy Cassata
Author
Cathy Cassata is a freelance writer who specializes in stories about health, mental health, medical news, and inspirational people. She writes with empathy and accuracy, and has a knack for connecting with readers in an insightful and engaging way. Cassata contributes to Healthline, Verywell, Yahoo, and more.
She previously worked for the American Association of Medical Assistants for eight years, writing and editing the magazine, marketing materials, and the website. Cassata completed the editing certificate program at the University of Chicago.
- Multiple Sclerosis. National Institute of Neurological Disorders and Stroke. January 23, 2023.
- Pain and Itching. National Multiple Sclerosis Society.