Postpartum Depression (PPD) Treatment


Psychotherapy for Postpartum Depression
Psychotherapy (aka talk therapy) is the first line of treatment for mild cases of PPD, says Nancy Byatt, DO, a perinatal psychiatrist and physician-scientist at the University of Massachusetts Chan Medical School in Worcester, where she focuses on women’s mental health, specifically in pregnancy and postpartum. Byatt is also the founding medical director of Massachusetts Child Psychiatry Access Program for Moms (MCPAP), an initiative she developed and launched to train physicians, midwives, and obstetrics nurses in identifying symptoms of depression in new moms.
Individual Therapy
In individual therapy, you’ll meet with a mental health professional weekly or at a similar cadence, Dr. Byatt says. Some people may attend therapy for a short time, such as three to six weeks, but others may continue to see their therapist for several months or more. Some types of therapy that can help people with PPD, says Byatt, include:
- Cognitive Behavioral Therapy (CBT) CBT helps people learn to identify inaccurate or negative thinking in order to view difficult situations more clearly and cope with them in a more constructive way. “With therapy like CBT, you’re changing your thought processes, becoming aware of them, and challenging them so they no longer make us anxious,” Byatt says.
- Interpersonal Therapy (IPT) IPT focuses on helping people improve their interpersonal relationships to relieve mental health symptoms. Researchers have found that four to eight sessions of IPT may help reduce symptoms of postpartum depression and improve satisfaction with family relationships and support, too.
Family and Couples Therapy
Group Therapy
Medication for Postpartum Depression
Medication used to treat PPD is similar to that for major depression, with a focus on antidepressants and anti-anxiety medication depending on symptoms and severity, says Nona Nichols, MD, a consultation-liaison psychiatrist at the Center for Adult Behavioral Health at Cleveland Clinic in Ohio.
“For women with mild-to-moderate depression, we would typically consider antidepressants, particularly the selective serotonin reuptake inhibitors (SSRIs), as the first-line medications. Fortunately, these medications are considered safe in breastfeeding as well,” Dr. Nichols says.
Standard Antidepressants
- Selective serotonin reuptake inhibitors (SSRIs), like sertraline (Zoloft) and fluoxetine (Prozac)
- Serotonin and norepinephrine reuptake inhibitors (SNRIs), like duloxetine (Cymbalta) and desvenlafaxine (Pristiq)
- Tricyclic antidepressants (TCAs), like amitriptyline (Elavil) and imipramine (Tofranil)
- Other antidepressants, such as bupropion (Wellbutrin, Zyban)
Brexanolone
Zuranolone
- Cold-like symptoms
- Dizziness
- Drowsiness
- Diarrhea
- Fatigue
- Urinary tract infections
- Sedation
- Confusion
Lifestyle Changes for Postpartum Depression
Some new parents may believe they need to ignore their needs to tend to their baby first, but this is a misconception, Byatt says. “The best way to take care of our children is to take care of ourselves,” she says. Nichols uses the acronym NESTS to explain the importance of self-care for PPD. It includes:
Nutrition
Try to focus on eating a diet rich in whole foods, such as fruits, vegetables, lean proteins, and healthy fats to support your energy levels and brain function and regulate mood, Byatt says.
Exercise
Sleep
Time for Yourself
Whether you’re taking time out each day for a shower or to catch up on your favorite show, it’s crucial for new parents to have moments for themselves, Nichols says. Byatt also recommends using this time for meditation, yoga, or any activity that allows you to pause and destress.
Support
It’s okay to ask for help, Byatt says. Consider joining a maternal support group to make friends, lean on your loved ones to batch cook and deliver some meals, or hire a professional cleaning service once a week if you can afford it. “I always ask my patients about their support systems and encourage them to ask for help and tag-team childcare as much as possible so that women have time to take care of themselves,” Nichols says.
Support for Postpartum Depression
National Maternal Mental Health Hotline
If you’re struggling with your mental health while pregnant or after giving birth, call or text 833-TLC-MAMA (833-852-6262), which is a free, confidential hotline for pregnant and new moms in English and Spanish, 24/7.
Postpartum Support International
Call 800-944-4PPD (4773) to connect with trained volunteers who provide support, encouragement, information and resources by phone, text, or email and connect pregnant, postpartum and post-loss families with local healthcare providers who treat perinatal mood and anxiety disorders.
American Academy of Family Physicians (AAFP)
AAFP is an organization representing family physicians in the United States. It provides information on PPD and a Postpartum Depression Toolkit with resources for PPD screening, diagnosis, treatment, and patient self-help.
The Takeaway
- Having a baby is a life-changing experience. New parents can feel overwhelmed, anxious, sad, or fearful. Postpartum depression is a common experience for women, with symptoms ranging from loneliness and crying spells to severe mood swings and disinterest in tending to yourself and your baby.
- Treatment options are effective and range from medication to therapy.
- Self-care is an important part of treatment — this includes making sure you’re eating healthy meals, getting adequate sleep and taking care of your mind and body.
Resources We Trust
- Mayo Clinic: Postpartum Depression: Diagnosis and Treatment
- Cleveland Clinic: Postpartum Depression
- The American College of Obstetricians and Gynecologists: Postpartum Depression
- U.S. Department of Health and Human Services Office on Women’s Health: Postpartum Depression
- Johns Hopkins Medicine: Baby Blues and Postpartum Depression: Mood Disorders and Pregnancy
- Khadka N et al. Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy Body Mass Index. JAMA Network Open. November 20, 2024.
- Postpartum depression. American College of Obstetricians and Gynecologists.
- Cognitive behavioral therapy. Mayo Clinic. March 16, 2019.
- Wang X et al. A systematic review of interpersonal psychotherapy for postpartum depression. Journal of Affective Disorders. October 15, 2023.
- Gillis BD et al. Group-based interventions for postpartum depression: An integrative review and conceptual model. Archives of Psychiatric Nursing. June 2019.
- What is peripartum depression? American Psychiatry Association.
- Postpartum depression: Management and Treatment. Cleveland Clinic.
- Postpartum depression breastfeeding and antidepressant therapy. American Academy of Family Physicians.
- Antidepressants: Get tips to cope with side effects. Mayo Clinic. September 12, 2019.
- Postpartum anxiety: Causes, symptoms, diagnosis and treatment. Cleveland Clinic.
- Baby Blues and Postpartum Depression: Mood Disorders and Pregnancy. Johns Hopkins Medicine.
- FDA approves first treatment for post-partum depression. Food and Drug Administration. March 19, 2019.
- Cornett EM et al. Postpartum major depression. American Family Physician. March 16, 2021.
- Zuranolone for the treatment of postpartum depression. American College of Obstetricians and Gynecologists. March 16, 2021.
- Khan R et al. Association of Maternal depression with diet: A systematic review. Asian Journal of Psychiatry. June 2019.
- Yang C et al. Association Between Dietary Quality and Postpartum Depression in Lactating Women: A Cross-Sectional Survey in Urban China. Frontiers in Nutrition. August 26, 2021.
- Exercise After Pregnancy. American College of Obstetricians and Gynecologists. August 2022.
- Marconcin P et al. Effects of Exercise during Pregnancy on Postpartum Depression: A Systematic Review of Meta-Analyses. Biology. December 15, 2021.
- Exercise After Pregnancy: How to Get Started. Mayo Clinic.
- Leistikow N et al. The role of sleep protection in preventing and treating postpartum depression. Seminars in Perinatology. October 2024.

Angela D. Harper, MD
Medical Reviewer
Angela D. Harper, MD, is in private practice at Columbia Psychiatric Associates in South Carolina, where she provides evaluations, medication management, and psychotherapy for adults.
A distinguished fellow of the American Psychiatric Association, Dr. Harper has worked as a psychiatrist throughout her career, serving a large number of patients in various settings, including a psychiatric hospital on the inpatient psychiatric and addiction units, a community mental health center, and a 350-bed nursing home and rehab facility. She has provided legal case consultation for a number of attorneys.
Harper graduated magna cum laude from Furman University with a bachelor's degree and cum laude from the University of South Carolina School of Medicine, where she also completed her residency in adult psychiatry. During residency, she won numerous awards, including the Laughlin Fellowship from the American College of Psychiatrists, the Ginsberg Fellowship from the American Association of Directors of Psychiatric Residency Training, and resident of the year and resident medical student teacher of the year. She was also the member-in-training trustee to the American Psychiatric Association board of trustees during her last two years of residency training.
Harper volunteered for a five-year term on her medical school's admission committee, has given numerous presentations, and has taught medical students and residents. She currently supervises a nurse practitioner. She is passionate about volunteering for the state medical board's medical disciplinary commission, on which she has served since 2015.
She and her husband are avid travelers and have been to over 55 countries and territories.

Carmen Chai
Author
Carmen Chai is a Canadian journalist and award-winning health reporter. Her interests include emerging medical research, exercise, nutrition, mental health, and maternal and pediatric health. She has covered global healthcare issues, including outbreaks of the Ebola and Zika viruses, anti-vaccination movements, and chronic diseases like obesity and Alzheimer’s.
Chai was a national health reporter at Global News in Toronto for 5 years, where she won multiple awards, including the Canadian Medical Association award for health reporting. Her work has also appeared in the Toronto Star, Vancouver Province, and the National Post. She received a bachelor’s degree in journalism from Ryerson University in Toronto.