What Is Ovulation?

Signs and Symptoms of Ovulation
- Mild pain in the abdomen or pelvis, or mittelschmerz
- Light vaginal bleeding or spotting
- Thin, clear, slippery discharge from the vagina
- Slight increase in resting (basal) body temperature
- Sore, swollen breasts
- Bloating
- Moodiness
- Increased sex drive
- Changes in appetite

Causes of Ovulation
Eggs develop in follicles inside the ovaries. Between the 6th and 14th day of the menstrual cycle, FSH and LH act on cells of the ovaries to help an egg mature. Between day 10 and 14, one egg fully matures. At around day 14, LH levels surge and trigger ovulation.
How Is Ovulation Diagnosed?
Another way to tell is by looking for signs of ovulation, like changes in cervical mucus or basal body temperature. During ovulation, vaginal discharge will become thin, clear, and slippery like egg whites, and the resting (basal) body temperature will rise slightly.
Treatment and Medication Options for Ovulation
Medication Options
- Clomiphene citrate (Clomid, Serophene) is a pill that stimulates the pituitary gland to release more FSH and LH, causing an egg to grow and be released.
- Letrozole (Femara) also increases FSH levels to induce ovulation.
- Gonadotropins (Menopur, Gonal-F, Follistum) are stronger medicines that trigger "superovulation," or the release of multiple eggs at once. These medicines can help people over 40 conceive by making several egg follicles develop at once.
- Metformin triggers ovulation by improving insulin resistance, a common cause of infertility in women with polycystic ovary syndrome (PCOS).
- Bromocriptine (Cycloset, Parlodel) helps with ovulation problems caused by excess production of the hormone prolactin from the pituitary gland.
Complementary and Integrative Therapies
- Acupuncture
- Herbal therapy
- Massage
- Meditation
Prevention of Ovulation
Lifestyle Changes for Ovulation
A few lifestyle changes can improve fertility, too.
Stay at a Healthy Weight
A body mass index between 19 and 24 is considered ideal for ovulation and pregnancy. Your doctor can recommend a diet and exercise program to help you stay at a healthy body weight.
Avoid Unhealthy Habits
Any of these things might alter hormone levels in ways that disrupt ovulation.
- Smoking: Chemicals in tobacco smoke lower levels of estrogen and progesterone. This drop in hormones can cause a reduction in egg quantity and quality. Smoking also damages the DNA in eggs, increasing the risk for miscarriage and birth defects.
- Heavy alcohol use: Drinking more than one or two alcoholic beverages each day could affect ovulation. Abstention from alcohol is best when you’re trying to conceive.
- Caffeine: While one or two small (6- to 8-ounce) cups of coffee a day shouldn't affect the ability to get pregnant, drinking more than that might cause problems with ovulation and reproduction.
- Chemical exposure: Exposure to pesticides, heavy metals, dry cleaning chemicals, and other toxins in the environment and at work might have a negative effect on ovulation and fertility.
Exercise in Moderation
Related Conditions
- Hypothyroidism (underactive thyroid gland) or hyperthyroidism (overactive thyroid gland)
- PCOS
- Premature ovarian failure, which is when the ovaries stop working before age 40
- Too much prolactin, a hormone made by the pituitary gland that stimulates milk production after childbirth
It's usually felt in the lower belly or pelvis, often on the side where the egg is released. Mittelschmerz isn't harmful and it shouldn't affect fertility.
The Takeaway
- Ovulation is the time during the menstrual cycle when a mature egg is released from the ovary, usually around day 14 of the menstrual cycle.
- Infertility drugs stimulate ovulation in women who are trying to conceive. Hormonal birth control stops ovulation.
- Smoking, exposure to toxic chemicals, exercising too vigorously, and drinking alcohol to excess can affect ovulation.
- If you experience any concerning symptoms during ovulation, such as persistent pain, it's critical to see a healthcare provider for evaluation to rule out underlying conditions.
Common Questions & Answers
Resources We Trust
- Cleveland Clinic: Ovulation
- Mayo Clinic: What Ovulation Signs Can I Watch for if I Want to Get Pregnant?
- Office on Women's Health: Ovulation Calculator
- MedlinePlus: Ovulation Home Test
- Harvard Health: Mid-Menstrual Cycle Pain (Mittelschmerz)
- Ovulation. Cleveland Clinic. July 8, 2022.
- Q&A About Ovulation with a Reproductive Endocrinology and Infertility Specialist. Northwestern Medicine. August 2022.
- Marnach M. Getting Pregnant. Mayo Clinic. July 9, 2024.
- JE Holesh et al. Physiology, Ovulation. StatPearls. May 1, 2023.
- Marnach M. What Ovulation Signs Can I Watch for if I Want to Get Pregnant? Mayo Clinic. July 9, 2024.
- Infertility. Mayo Clinic. September 13, 2023.
- Ovulation Induction. UCSF Center for Reproductive Health.
- Female Infertility. Mayo Clinic. August 27, 2021.
- Smith JF et al. The Use of Complementary and Alternative Fertility Treatment in Couples Seeking Fertility Care: Data from a Prospective Cohort in the United States. Fertility and Sterility. March 24, 2010.
- Birth Control Options. Cleveland Clinic. August 18, 2022.
- Mayo Clinic Staff. Female Fertility: Why Lifestyle Choices Count. Mayo Clinic. January 9, 2024.
- Skiadas CC. Fertility and Your Weight: How They're Connected. Penn Medicine. October 7, 2022.
- Dhage VD et al. A Narrative Review on the Impact of Smoking on Female Fertility. Cureus. April 16, 2024.
- Anwar MY et al. The association between alcohol intake and fecundability during menstrual cycle phases. Human Reproduction. June 8, 2021.
- Jain M et al. Environmental Toxins and Infertility. StatPearls. January 19, 2025.
- Mussawar M et al. The effect of physical activity on fertility: a mini-review. F&S Reports. April 14, 2023.
- Mittelschmerz. Mayo Clinic. February 13, 2024.
- Ovulation Pain. Cleveland Clinic. February 9, 2023.

John Paul McHugh, MD
Medical Reviewer
John Paul McHugh, MD, is an obstetrician-gynecologist and lifestyle medicine specialist in southern California. He has always placed wellness at the center of his work, in both delivering babies and improving practice standards. Dr. McHugh believes that bringing lifestyle medicine to the center of health and wellness empowers patients to make the change they seek and enjoy the benefits of true wellness.
He is a graduate of Harvard Medical School and the Massachusetts Institute of Technology and a fellow of the American College of Lifestyle Medicine. He served as a department chair at Scripps Mercy Hospital in San Diego and is now the chair-elect for the American College of Obstetricians and Gynecologists for California.
He has published several articles in the American Journal of Lifestyle Medicine and served as a peer reviewer for many articles. He contributed to the first textbook of lifestyle medicine in women's health: Improving Women's Health Across the Lifespan.
