Ulcerative Colitis and Erectile Dysfunction: Understanding the Link

What’s the Connection Between Ulcerative Colitis and Erectile Dysfunction?

What’s the Connection Between Ulcerative Colitis and Erectile Dysfunction?
Adobe Stock

Ulcerative colitis (UC) can take a toll on your sexual health. “Erectile dysfunction is relatively common in men with ulcerative colitis,” says Robert Valenzuela, MD, a prosthetic and general urologist at Mount Sinai in New York City.

Unfortunately, he says, “Sexual health is rarely a primary topic during medical appointments unless the patient brings it up.”

Why Is Erectile Dysfunction So Common in Men With UC?

Erectile dysfunction (ED) seems to be more common in men with ulcerative colitis.

In an analysis of 14 studies involving over 32,000 men with inflammatory bowel disease (IBD), including UC, researchers found that 27 percent of participants reported having ED. Those with depression were more than 3 times as likely to have erectile dysfunction, while those with greater disease activity were about twice as likely. Surgery related to IBD raised the risk by about 30 percent.

Other studies found that 34 percent of men with IBD reported having some type of sexual dysfunction, compared with 63 percent of women with IBD.

Several factors contribute to erectile dysfunction in men with UC.

Greater Disease Activity and Worse Symptoms

More severe disease activity, or active UC flares, may cause ED in the following ways:

  • Inflammation Substances that your body releases when inflammation occurs can inhibit the production of testosterone and are linked to ED.

  • Pain You’re less likely to be able to achieve or maintain an erection when you’re experiencing pain or discomfort. One study found that men with anal or rectal pain were more than twice as likely to have erectile dysfunction.

  • Fatigue UC flares can sap your energy and interest in intimacy, says Dr. Valenzuela.
  • Bowel Movements Having more frequent or urgent bowel movements can distract from arousal and interrupt sexual activity. “Fear of having an incontinent episode during intercourse [often] makes the idea of having pleasurable intercourse worrisome to patients with IBD,” says Lisa Fasone, a certified physician assistant in urology at Northwestern Medicine in Illinois.
  • Nutrition Deficiencies Some nutrient deficiencies linked to IBD, such as zinc deficiency, can reduce testosterone production and affect sexual function.

Effects of Treatment

Surgery related to your UC, such as procedures for a J-pouch or ostomy, can make sexual activity difficult or impossible as you recover. Even after you’ve adapted physically, you may have body image difficulties related to your surgery. While 51 percent of people with IBD who haven’t had surgery report having an impaired body image, this number rises to 81 percent for those who’ve had surgery.

Physical challenges may persist long after recovery. “For men who have undergone surgery, nerve damage or structural changes from colectomy, J-pouch, or ostomy procedures can lead to altered erectile function,” says Valenzuela.

Fasone says, “Certain treatments for IBD may cause hypogonadism, or low testosterone levels, which can contribute to ED.” Research suggests that up to 4 in 10 people with Crohn’s or colitis have low testosterone levels. This could be because of several possible factors, including steroid medications, opiate medications, inflammation, and stress.

Psychological Factors

Psychological issues are a major contributor to erectile dysfunction in men with UC. “Men with IBD are at an increased risk for having anxiety and depression, which may impact erectile health,” says Fanone. What’s more, you may not feel good about the way your body looks or functions, which can harm your sexual confidence and contribute to erectile dysfunction.

To make things more complicated, some antidepressants can contribute to erectile dysfunction. They may also reduce sexual desire or make it difficult to reach orgasm. Antidepressants most likely to cause these undesired sexual effects include selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors such as venlafaxine (Effexor XR).


How to Manage Erectile Dysfunction When You Have UC

The first step in getting help for erectile dysfunction is talking about it. That can start you on the path to getting the right treatment.

Taking to Your Doctor

Many healthcare providers don’t ask men with ulcerative colitis about erectile dysfunction or other sexual issues. “Sexual health is an important aspect of overall health and wellness, and we need to get better about talking about it,” says Fasone.

“Despite its prevalence, many men are reluctant to discuss ED with their doctors or partners due to feelings of embarrassment, stigma, or the misconception that it is a separate issue unrelated to UC,” says Valenzuela. “Concerns about masculinity and the fear of being judged often prevent men from seeking help.”

You may be wondering how to talk to your doctor, about this sensitive issue, and the key is to be open and honest. Valenzuela says that urologists are often more comfortable discussing ED treatments than other healthcare providers, so don’t be afraid to ask for a referral to a urologist if this interests you. You should also feel free to raise any concerns with your gastroenterologist or primary care doctor.

Medications and Other Treatments

Both medications and devices can help treat erectile dysfunction, depending on your health situation and treatment goals and preferences.

Phosphodiesterase Type 5 (PDE5) Inhibitors This group of medications can help with ED by improving blood flow to the penis. These drugs are generally safe for most men with UC, says Valenzuela:

  • avanafil (Stendra)
  • sildenafil (Viagra)
  • tadalafil (Cialis)
  • vardenafil (Levitra)

It takes between 15 and 60 minutes for PDE5 inhibitors to start working, depending on which drug you take. They don’t automatically cause an erection, so you’ll still need to become aroused for them to work.

One study found that in men with ED who underwent bowel surgery for either IBD or rectal cancer, PDE5 inhibitors were linked to improved erections after three months.

It may be unsafe to take these drugs if you have certain forms of cardiovascular disease, and you shouldn’t take them if you use heart drugs called nitrates due to the risk of dangerously low blood pressure. If you are prescribed a drug called an alpha blocker for urinary symptoms, you should time your dose at least four hours apart from a PDE5 inhibitor, also because of the risk for low blood pressure.

Testosterone Replacement Therapy If you have low testosterone levels due to chronic inflammation from your UC, you may benefit from testosterone replacement therapy. But this treatment requires careful monitoring due to risks, including blood clots, says Valenzuela.

Erectile Aids A vacuum erection device uses suction to encourage blood flow and may be particularly useful for men who cannot or prefer not to take oral medications, says Valenzuela. One study concluded that vacuum erection devices were linked to improved erections after 12 months.

Tips for Building a Positive Self-Image With UC

It’s common for your self-image, including your body image, to take a hit from ulcerative colitis symptoms or complications. But there are ways to fight back and rebuild your self-image, which might help with your sexual confidence and function:

  • Shift your focus from flaws to strengths. “Instead of dwelling on physical changes caused by UC, such as weight fluctuations or surgical scars, men can emphasize what their bodies can still achieve,” says Valenzuela.
  • Get regular exercise. Both aerobic and resistance training can help boost feelings of self-efficacy and well-being. Exercise can also boost testosterone levels, which can help with ED, says Valenzuela.

  • Consider counseling. Seeing a counselor or therapist, such as a psychologist or sex therapist, may be beneficial for some men with UC, says Fasone. You can also look into IBD support groups in your area or online, which may help you connect with other men and share your experiences and concerns.

How to Have a Better Sex Life With UC

If you’re experiencing erectile dysfunction or other issues with intimacy because of your ulcerative colitis, you may benefit from certain adjustments to your sex life. Often that means letting go of past expectations for how you should perform sexually or what a successful sexual experience looks like.

Making sure that your UC is well managed and flares are limited can be key to improving your sexual health, Fasone says. But aside from that, here are some suggestions that may help improve your sex life with UC:

  • Plan intimacy around your energy level. If you’re less fatigued in the morning or after resting, these times may be better for intimacy than just before your bedtime.
  • Try different positions. Lying on your side, or spooning, can reduce strain on your abdomen or joints, Valenzuela says.
  • Use heat therapy for comfort. A warm bath or heating pad can help your pelvic and abdominal muscles relax, which may reduce pain and discomfort during sex.
  • Have a routine for bowel urgency. Avoid any trigger foods and go to the bathroom before intimacy, and keep supplies like wipes or towels nearby in case you need them.
  • Use wraps to feel comfortable. If you have an ostomy bag or sensitive surgical scars, a specialized wrap can cover the area or keep your bag secure.
  • Set the mood. Dim lighting, soft bedding or blankets, scented candles, or music can help make you feel sexy and comfortable.
  • Broaden your sexual horizons. Sex can mean many different things, including nonpenetrative and sensual activities like giving massages, as well as oral or manual genital stimulation. You can also experiment with different kinds of lubricants.

Above all, “open communication with a partner is essential, helping to ease concerns, strengthen emotional intimacy, and address body image insecurities,” says Valenzuela. Talk with your partner ahead of a sexual encounter about what both of you can do to make the experience as fulfilling as possible.

The Takeaway

  • UC can cause erectile dysfunction through inflammation, pain, fatigue, worries about incontinence, aftereffects of surgery, or body image difficulties.
  • Options for ED treatment include medications, erectile aid devices, counseling, and adaptations to make sexual activity more comfortable and pleasurable.
  • Talking openly about sexual difficulties with your healthcare provider and your partner can help you find the right solutions.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Wu X et al. The Prevalence and Associated Risk Factors of Erectile Dysfunction in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Journal of Sexual Medicine. April 28, 2022.
  2. Nardone OM et al. Prevalence of Sexual Dysfunction in Inflammatory Bowel Disease: Systematic Review and Meta-analysis. Journal of Crohn’s and Colitis. August 26, 2024.
  3. Sex, Intimacy, and IBD. Crohn’s & Colitis Foundation. May 2021.
  4. Chen B et al. Inflammatory Bowel Disease Is Associated With Worse Sexual Function: A Systematic Review and Meta-analysis. Translational Andrology and Urology. July 26, 2022.
  5. Ma HF et al. Erectile Dysfunction, Depression, and Anxiety in Patients With Functional Anorectal Pain: A Case-Control Study. Journal of Sexual Medicine. June 22, 2023.
  6. Reproductive Health and Fertility. Crohn’s and Colitis UK. April 2023.
  7. Allen N. Antidepressants: Which Cause the Fewest Sexual Side Effects? Mayo Clinic. August 24, 2024.
  8. Which Drug for Erectile Dysfunction? Harvard Health Publishing. August 9, 2022.
  9. Notarnicola M et al. PDE-5i Management of Erectile Dysfunction After Rectal Surgery: A Systematic Review Focusing on Treatment Efficacy. American Journal of Men's Health. October 28, 2020.
  10. Testosterone Therapy: Potential Benefits and Risks as You Age. Mayo Clinic. January 19, 2024.
  11. Quick Dose: Can Physical Activity Affect Testosterone? Northwestern Medicine. September 2022.

Yuying Luo, MD

Medical Reviewer

Yuying Luo, MD, is an assistant professor of medicine at Mount Sinai West and Morningside in New York City. She aims to deliver evidence-based, patient-centered, and holistic care for her patients.

Her clinical and research focus includes patients with disorders of gut-brain interaction such as irritable bowel syndrome and functional dyspepsia; patients with lower gastrointestinal motility (constipation) disorders and defecatory and anorectal disorders (such as dyssynergic defecation); and women’s gastrointestinal health.

She graduated from Harvard with a bachelor's degree in molecular and cellular biology and received her MD from the NYU Grossman School of Medicine. She completed her residency in internal medicine at the Icahn School of Medicine at Mount Sinai, where she was also chief resident. She completed her gastroenterology fellowship at Mount Sinai Hospital and was also chief fellow.

Quinn Phillips

Author

A freelance health writer and editor based in Wisconsin, Quinn Phillips has a degree in government from Harvard University. He writes on a variety of topics, but is especially interested in the intersection of health and public policy. Phillips has written for various publications and websites, such as Diabetes Self-Management, Practical Diabetology, and Gluten-Free Living, among others.