Top 15 RD-Approved Prime Day Supplements 2025

15 RD-Approved Supplement Deals Our Editors Are Shopping This Prime Day 2025

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With so many supplements marked down for Prime Day 2025, it’s tempting to fill your cart. But while big discounts are exciting, not all supplements are created equal. Quality, dosage, sourcing, and third-party testing all matter if you want something safe and effective.

To help you shop smarter, Everyday Health editors partnered with an RD to review dozens of top-rated products to find supplement deals that are truly worth it. Whether you're looking to support sleep, digestion, energy, or immunity, these picks deliver quality and value so you can feel good about what you're putting in your body.

Before you start shopping, though, as a reminder, it’s always a good idea to check with your doctor or a registered dietitian before adding any new supplement to your routine, especially if you have a health condition or take medications.

Vital Proteins Collagen Peptides

$32.09 at Amazon
$50Now 36% Off
Vital Proteins is a universally loved collagen brand for good reason. Each scoop delivers 20 grams (g) of collagen peptides from grass-fed, pasture-raised bovine sources to support healthy skin, joints, and hair. Collagen is a key player in keeping your connective tissues strong, and studies show it might even help reduce joint discomfort and boost skin hydration.

 It’s unflavored, easily dissolves in hot or cold drinks, and is free from added sugars and artificial flavors.

Xymogen K2-D3 5000

$39.58 at Amazon
Xymogen K2-D3 pairs two highly absorbable forms of vitamins D3 and K2 to support your bones, heart, and immune system. Each capsule contains 5,000 IU of vitamin D3 to help your body absorb calcium, and 90 mcg of K2 to ensure calcium is directed to your bones rather than to your arteries, where it could do more harm than good.

 With third-party testing for purity and potency, you can trust you're getting high-quality ingredients without contaminants.

Beekeeper's Naturals Propolis Throat Spray

$12.53 at Amazon
$13.92Now 10% Off
Beekeeper’s Naturals taps into the immune-boosting power of bee propolis, a natural resin bees make and use to protect their hives. Packed with antioxidants and antimicrobial properties, propolis has been used for centuries to soothe scratchy throats and help the body fend off seasonal immune shifts.

 It’s a go-to for travel, back-to-school season, or anytime you feel something coming on. You’ll be glad to have it on hand when your throat needs a little TLC.

Gaia Herbs Ashwagandha Root

$22.67 at Amazon
$25.19Now 10% Off
Feeling stressed? You're not alone, but Gaia Herbs Ashwagandha Root may help your body handle it with more ease. Ashwagandha is an adaptogen that helps your body better adapt to stress. Each serving delivers 350 milligrams (mg) of organic ashwagandha root extract along with 250 mg of withanolides, the active compounds that help give this adaptogen its calming, balancing power.

 Gaia Herbs sources organic ingredients and tests for purity and contaminants, so you can feel confident you’re getting high-quality, effective stress support.

Liquid I.V. Hydration Multiplier, Strawberry Lemonade

$24.02 at Amazon
When the summer heat hits, staying hydrated is essential. Liquid I.V. Hydration Multiplier helps replenish fluids faster than water alone with a science-backed blend of electrolytes, B vitamins, and a touch of glucose for quick energy. It’s great for post-workout recovery, travel, or hot days. If you're watching your sodium intake due to a health condition, skip electrolyte powders, but for many, this is a flavorful, functional way to stay hydrated.

Ritual Synbiotic+

$51.29 at Amazon
$59.74Now 14% Off
Ritual Synbiotic+ combines prebiotics, probiotics, and postbiotics into one, easy-to-take formula. It features two clinically studied strains, Lactobacillus rhamnosus and Bifidobacterium animalis, to support digestion and immune health from the inside out.

 The prebiotics feed your good gut bacteria, the probiotics help maintain a healthy microbiome, and the postbiotic (a product of good bacteria during fermentation) helps create a happy gut environment.

 And true to Ritual’s standards, there are no artificial ingredients, no major allergens, and everything is third-party tested.

Microbiome Labs MegaSporeBiotic

$58.45 at Amazon
$64.95Now 10% Off
Microbiome Labs features a blend of five clinically studied Bacillus strains designed to support gut balance, digestion, and immune health. This product is spore-based, which means these resilient probiotics stay stable without refrigeration and are built to survive the journey through your digestive tract. Research suggests spore-based strains may colonize the gut, which means more lasting benefits for your microbiome.

Mary Ruth's Liquid Morning Multivitamin + Hair Growth

$67.45 at Amazon
$74.95Now 10% Off
If swallowing pills isn’t your favorite, Mary Ruth’s Liquid Morning Multivitamin + Hair Growth offers a tasty way to nourish your body and support hair health. This liquid formula goes beyond the basics, blending essential vitamins and minerals with hair-loving nutrients like biotin, zinc, and B vitamins.

 It’s vegan-friendly, sugar-free, and comes in a tasty berry flavor that makes taking vitamins feel more like a treat than a chore.

Llama Naturals Kids Multivitamin

$24.29 at Amazon
$26.99Now 10% Off
Kids love gummy vitamins, but many are packed with added sugar or artificial ingredients. Llama Naturals Kids Multivitamin skips unnecessary additives and delivers 13 essential vitamins and minerals from organic fruits and veggies, including vitamin D, zinc, and B12. This plant-based, no-sugar-added formula is gentle on little tummies and allergen-friendly. It’s a smart choice for picky eaters to help fill nutritional gaps.

New Chapter Every Woman’s One Daily Multivitamin

$32.46 at Amazon
$36.70Now 12% Off
New Chapter Every Woman’s One Daily Multivitamin is a comprehensive formula made for women’s unique needs. It contains essential vitamins and minerals, plus added blends for stress, hormone, and immune support. Made with organic, non-GMO, and sustainably sourced ingredients, it’s gentle on the stomach and only requires one tablet daily.

Jarrow Formulas MagMind (Magnesium L-Threonate)

$31.30 at Amazon
$48.49Now 35% Off
Jarrow Formulas Magnesium delivers 144 mg of magnesium L-threonate — one of the few types of magnesium shown to effectively cross the blood-brain barrier. That means it’s especially helpful for supporting cognitive function and mental clarity and may even help you sleep better.

 It’s gentle on the stomach, vegetarian-friendly, free from common allergens, and third-party tested for quality and purity.

Aloha Organic Plant-Based Protein Bars

$19.50 at Amazon
$36.99Now 47% Off
Aloha Organic Protein Bars are the kind of snack you’ll actually look forward to eating. Made with plant-based ingredients like organic brown rice and pumpkin seed protein, each bar delivers 14 g of protein without any dairy, soy, or gluten. They’re non-GMO, free from artificial flavors, and lightly sweetened with brown rice syrup, monk fruit, or brown sugar (depending on the flavor) for a touch of sweetness. Whether you need a post-workout bite or a midafternoon pick-me-up, these are a delicious way to fuel up.

Sports Research Omega-3 Fish Oil

$38.65 at Amazon
$42.95Now 10% Off
Sports Research Omega-3 Fish Oil delivers high-quality omega-3s from sustainably sourced, wild-caught Alaskan pollock. Each teaspoon packs a potent dose of 1500 mg EPA and 1000 mg DHA, the essential fatty acids that support heart, brain, and joint health.

 It’s third-party tested for heavy metals and contaminants, and thanks to the natural lemon flavor, you get all the benefits of fish oil without the dreaded fishy aftertaste.

Vega Original Protein Powder, Creamy Vanilla

$16.14 at Amazon
$26.99Now 40% Off
Vega Original Essential Protein Powder is a solid pick if you're looking for a plant-based protein. Each serving delivers 25 g of protein from pea protein along with 3 g of fiber to help keep you satisfied. It’s naturally sweetened with stevia, non-GMO certified, gluten-free, and made without artificial sweeteners. Great in smoothies or mixed with your favorite nondairy milk, it’s a simple, tasty way to fuel your day.

Legion Micronized Creatine Monohydrate

$31.49 at Amazon
$34.99Now 10% Off
Creatine is one of the most well-researched supplements for athletic performance, and it’s not just for gym bros.

Legion Micronized Creatine Monohydrate delivers 5 g of pure, micronized creatine per serving to support strength, muscle growth, and even cognitive function, like mental clarity and reduced brain fog.

 Backed by third-party testing for purity and potency, it’s unflavored, easy to mix, and made without artificial additives.

Kind Bar Minis, Variety Pack

$20.89 at Amazon
$21.99Now 5% Off
Kind Bar Minis are perfectly portioned, snack-sized bars made with whole nuts, seeds, and real ingredients. With just 90 to 100 calories each, they’re a smart way to satisfy cravings while getting a boost of healthy fats and fiber. Gluten-free, non-GMO, and free from artificial sweeteners, they come in a variety of flavors, and their grab-and-go size makes them ideal for busy days or when that midafternoon energy dip hits.

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We independently investigate and recommend products and services we believe will enrich the lives of our readers and meet their specific needs. You can trust our reviews because we do the legwork for you. Read more about why you can trust us.

Caitlin Beale, MS, RDN

Author

Caitlin Beale, MS, RDN, is a registered dietitian and freelance health writer with experience in clinical nutrition, education, research, and private practice. Caitlin’s special interests include women's health, gut health, autoimmunity, and reproductive health. Committed to the belief that health information should be accessible to all, she is passionate about empowering individuals to make positive changes for their well-being. Caitlin holds advanced training certificates in women's health and integrative and functional nutrition.

Caitlin was born and raised in northern California, where she resides with her family. An avid lover of sunshine and the outdoors, she finds joy in activities such as visiting the beach, exercising, cooking, and indulging in a good read. You can find Caitlin’s writing in a variety of outlets and brands, including Motherly, Nourish, Signos, Greatest, Pure Encapsulations, Abbott, and Clue, among others.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  2. Ballegooijen AJ et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. International Journal of Endocrinology. September 12, 2017.
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  4. Arumugam V et al. Effects of Ashwagandha (Withania Somnifera) on Stress and Anxiety: A Systematic Review and Meta-Analysis. Explore. November 2024.
  5. Szajewska H et al. Health benefits of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12 in children. Postgraduate Medicine. June 2020.
  6. Ma L et al. Postbiotics in Human Health: A Narrative Review. Nutrients. January 6, 2023.
  7. Colom J et al. Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study. Frontiers in Microbiology. August 2021.
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  11. Banaszak M et al. Role of Omega-3 Fatty Acids Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) as Modulatory and Anti-Inflammatory Agents in Noncommunicable Diet-Related Diseases - Reports from the Last 10 Years. Clinical Nutrition ESPEN. October 2024.
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