What Causes Obesity?

A variety of factors — from genetics to diet and exercise to where you live — play a role in obesity risk. Understanding the potential underlying causes of obesity is essential to help individuals lose weight and improve their health.
What Causes Obesity?
Avoiding obesity is not as simple as burning the same amount of calories that you’re taking in. Whether someone develops obesity or not is often much more complex.
“The causes and risk factors for obesity are multifactorial: genetics, environment, lifestyle, and even socioeconomic status,” says Mir Ali, MD, a bariatric surgeon and the medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California.
Below are the most common causes of obesity.
Diet Quality
When we eat, our bodies turn food into energy that’s used for everyday functions and physical activity. The energy collected that isn’t used gets stored for the future as fat. If you regularly take in significantly more energy than the body can use each day, you may be at risk for developing obesity.
“Processed foods are high in sugar and fat and low in fiber, which makes it easy to overeat,” says Lisa Young, PhD, RDN, a New York City–based nutrition consultant and author. She also points to larger portion sizes in general as a contributor to overeating.
Lifestyle Choices
Lifestyle factors, including lack of regular exercise, excessive time sitting during the day, and insufficient quality sleep, can all influence obesity risk.
Routine physical activity allows the body to use the energy it takes in through food. If your activity levels are well matched with your calorie intake, your risk for obesity may be reduced. People who spend most of their day sitting, whether due to work or leisure, may not get the recommended amount of physical activity, leading to an increased risk of obesity.
- Children ages 3 to 5 should be physically active throughout the day.
- Children and adolescents ages 6 to 17 should get one hour or more of moderate or intense physical activity per day.
- Adults should get at least 150 minutes of moderate to intense physical activity throughout the week.
Genetics
Environment
Your environment — from where you live to where you work and play to whom you interact with on a regular basis — can impact your health.
Social Determinants
Stress
Other Medical Conditions
Other medical conditions are associated with weight gain, which could potentially lead to obesity. These conditions include:
- Bardet-Biedl syndrome
- Prader-Willi syndrome
- Polycystic ovary syndrome
- Cushing’s syndrome
- Underactive thyroid
Certain Medications
Some medications can cause weight gain as a side effect by creating an increased appetite when hormones regulating hunger are disrupted. Over time, these could be a contributor to obesity.
The National Heart, Lung, and Blood Institute lists the following medications as causes of weight gain.
- Some antidepressants
- Antipsychotics
- Beta-blockers (a type of high blood pressure medication)
- Some forms of birth control
- Some medications used to treat chronic pain
- Glucocorticoids
- Insulin
If you feel like your medication is causing weight gain, talk to a healthcare professional. They may be able to recommend something different that doesn’t impact your weight.
The Takeaway
- A variety of factors, from genetics to lifestyle choices to your environment, play a role in obesity risk.
- While certain factors like family history cannot be controlled, making changes to diet, physical activity levels, and stress can help reduce your risk of obesity.
- Some medical conditions, along with certain medications like antidepressants, antipsychotics, and birth control, can sometimes lead to weight gain. Talk to your doctor if you have concerns about any of the medication you’re taking.
Resources We Trust
- Mayo Clinic: Obesity
- Cleveland Clinic: Obesity
- Harvard Health Publishing: Hidden Causes of Weight Gain
- National Heart, Lung, and Blood Institute: Overweight and Obesity: Causes and Risk Factors
- Centers for Disease Control and Prevention: Risk Factors for Obesity

Adam Gilden, MD, MSCE
Medical Reviewer
Adam Gilden, MD, MSCE, is an associate director of the Obesity Medicine Fellowship at University of Colorado School of Medicine and associate director of the Colorado University Medicine Weight Management and Wellness Clinic in Aurora. Dr. Gilden works in a multidisciplinary academic center with other physicians, nurse practitioners, registered dietitians, and a psychologist, and collaborates closely with bariatric surgeons.
Gilden is very involved in education in obesity medicine, lecturing in one of the obesity medicine board review courses and serving as the lead author on the Annals of Internal Medicine article "In the Clinic" on obesity.
He lives in Denver, where he enjoys spending time with family, and playing tennis.

Rena Goldman
Author
Curious about what it takes to live your healthiest life in a modern society, Goldman is passionate about empowering readers with the information to make educated decisions about their health. She has spent years interviewing clinicians and working with them to ensure content is medically accurate. This experience has helped her build in-depth knowledge in the health and wellness space.
Goldman's work has been featured in numerous online health and lifestyle publications, including Everyday Health, Health.com, Healthline, Business Insider, Psych Central, and U.S. News & World Report.
She's based in Los Angeles, where she enjoys good vegan food, trying new workout trends, and hiking with her dachshund, Charlie.
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