New COVID Variant NB.1.8.1 Detected in the U.S.

Now there’s a new one: NB.1.8.1.
Can You Get a Flu Shot and a COVID Vaccine at the Same Time?

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NB.1.8.1 COVID Variant Could Fuel Summer Surge
But experts think the new variant may lead to an escalation in U.S. cases in the weeks ahead, according to Amy Edwards, MD, an assistant professor at the Case Western Reserve University School of Medicine in Cleveland who specializes in pediatric infectious diseases.
“There have been late spring or summer surges in past years, and this variant could push one this year,” says Dr. Edwards.
On a positive note, public health officials are not expecting a rise in severe illness due to this mutation, despite reports of more hospitalizations in Asia.
The WHO reports that routine clinical surveillance does not indicate any signs of increased severity associated with NB.1.8.1 compared with previously circulating variants.
Vaccination Provides Protection Against NB.1.8.1
Based on all the preliminary information about NB.1.8.1, vaccination should continue to protect people from severe illness even if the virus is more transmissible, says Mark Rupp, MD, a professor in the division of infectious diseases at the University of Nebraska Medical Center in Omaha .
“NB.1.8.1 is from a lineage of omicron, so we expect that it is related closely enough to variants targeted by the current vaccine and the vaccine proposed for the coming season,” says Dr. Rupp.
He suggests that keeping up with vaccination can help limit the severity and spread of illness.
“These spikes of activity with the virus usually correspond with a new variant that's more transmissible and a period of time when people's immunity has waned so they are more susceptible to the virus,” says Rupp.
He adds that it’s important for vaccines to remain widely available and reimbursed by insurance plans — particularly for people who are at high risk of severe illness and who want to do what they can to protect themselves.
What Are the Symptoms of NB.1.8.1?
Symptoms of infection from the latest variant appear to be the same as previous iterations of the virus, according to Rupp. These include:
- Nasal congestion or runny nose
- Sore throat
- Fatigue
- Headache
- Cough
- Muscle or body aches
- Fever or chills
- Nausea or vomiting
- Diarrhea
- New loss of taste and smell
- Shortness of breath or difficulty breathing
If you’re showing signs of illness, Edwards recommends taking measures to prevent spreading it to others — such as staying home, wearing a mask, and avoiding crowded venues — especially for those who are most vulnerable.
“COVID is never going away,” says Edwards. “We need to do what we can to protect ourselves and others from this and other major respiratory illnesses.”
- The Changing Threat of COVID-19. Centers for Disease Control and Prevention. February 23, 2024.
- Velázquez F. Coronavirus Mutations and Variants: What Does It Mean? Spokane Regional Health District. April 1, 2021.
- Cosar B et al. SARS-CoV-2 Mutations and their Viral Variants. Cytokine & Growth Factor Reviews. February 2022.
- WHO TAG-VE Risk Evaluation for SARS-CoV-2 Variant Under Monitoring: NB.1.8.1. World Health Organization. May 23, 2025.
- Variant Report 2025-05-21. Neherlab. May 2025.
- Tin A. New COVID Variant NB.1.8.1 Behind Surge in China, Now Setected in U.S. CBS News. May 23, 2025.

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Don Rauf
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Don Rauf has been a freelance health writer for over 12 years and his writing has been featured in HealthDay, CBS News, WebMD, U.S. News & World Report, Mental Floss, United Press International (UPI), Health, and MedicineNet. He was previously a reporter for DailyRx.com where he covered stories related to cardiology, diabetes, lung cancer, prostate cancer, erectile dysfunction, menopause, and allergies. He has interviewed doctors and pharmaceutical representatives in the U.S. and abroad.
He is a prolific writer and has written more than 50 books, including Lost America: Vanished Civilizations, Abandoned Towns, and Roadside Attractions. Rauf lives in Seattle, Washington.