What Are the Symptoms of the New COVID-19 Variant N B.1.8.1?
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New COVID Variant NB.1.8.1 Detected in the U.S.

Early evidence suggests NB.1.8.1 spreads more easily than earlier variants, which could raise the risk of a potential summer spike in infections.
New COVID Variant NB.1.8.1 Detected in the U.S.
Eva Kali/Adobe Stock; Everyday Health
Although severe illness from COVID-19 has been on a downward trajectory, the coronavirus still maintains its remarkable ability to mutate.

Thousands of variants have emerged since the start of the pandemic.

Now there’s a new one: NB.1.8.1.

The World Health Organization (WHO) recently began monitoring NB.1.8.1 due to rising global case counts, particularly in China and Hong Kong, where hospitalizations due to COVID-19 are increasing.

The latest available WHO data from 22 countries shows that the prevalence of NB.1.8.1 has quadrupled over the last month, jumping from 2.5 percent to 10.7 percent of virus samples over the four weeks ending April 27.

Can You Get a Flu Shot and a COVID Vaccine at the Same Time?

It’s perfectly safe and medically acceptable to get a flu shot and a COVID-19 booster at the same time, says Purvi S. Parikh, MD, of NYU Langone Health. One day we might even see the two vaccines combined.
Can You Get a Flu Shot and a COVID Vaccine at the Same Time?

NB.1.8.1 COVID Variant Could Fuel Summer Surge

In the United States, the NB.1.8.1 variant has been detected in several U.S. airports by the Centers for Disease Control and Prevention (CDC).

But experts think the new variant may lead to an escalation in U.S. cases in the weeks ahead, according to Amy Edwards, MD, an assistant professor at the Case Western Reserve University School of Medicine in Cleveland who specializes in pediatric infectious diseases.

“There have been late spring or summer surges in past years, and this variant could push one this year,” says Dr. Edwards.

On a positive note, public health officials are not expecting a rise in severe illness due to this mutation, despite reports of more hospitalizations in Asia.

The WHO reports that routine clinical surveillance does not indicate any signs of increased severity associated with NB.1.8.1 compared with previously circulating variants.

“Currently there is no evidence of increases in indicators like COVID-19-related ICU admissions and deaths per hospitalizations, or all-cause mortality,” writes the global health organization.

Vaccination Provides Protection Against NB.1.8.1

Based on all the preliminary information about NB.1.8.1, vaccination should continue to protect people from severe illness even if the virus is more transmissible, says Mark Rupp, MD, a professor in the division of infectious diseases at the University of Nebraska Medical Center in Omaha .

“NB.1.8.1 is from a lineage of omicron, so we expect that it is related closely enough to variants targeted by the current vaccine and the vaccine proposed for the coming season,” says Dr. Rupp.

He suggests that keeping up with vaccination can help limit the severity and spread of illness.

“These spikes of activity with the virus usually correspond with a new variant that's more transmissible and a period of time when people's immunity has waned so they are more susceptible to the virus,” says Rupp.

He adds that it’s important for vaccines to remain widely available and reimbursed by insurance plans — particularly for people who are at high risk of severe illness and who want to do what they can to protect themselves.

What Are the Symptoms of NB.1.8.1?

Symptoms of infection from the latest variant appear to be the same as previous iterations of the virus, according to Rupp. These include:

  • Nasal congestion or runny nose
  • Sore throat
  • Fatigue
  • Headache
  • Cough
  • Muscle or body aches
  • Fever or chills
  • Nausea or vomiting
  • Diarrhea
  • New loss of taste and smell
  • Shortness of breath or difficulty breathing

If you’re showing signs of illness, Edwards recommends taking measures to prevent spreading it to others — such as staying home, wearing a mask, and avoiding crowded venues — especially for those who are most vulnerable.

“COVID is never going away,” says Edwards. “We need to do what we can to protect ourselves and others from this and other major respiratory illnesses.”

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. The Changing Threat of COVID-19. Centers for Disease Control and Prevention. February 23, 2024.
  2. Velázquez F. Coronavirus Mutations and Variants: What Does It Mean? Spokane Regional Health District. April 1, 2021.
  3. Cosar B et al. SARS-CoV-2 Mutations and their Viral Variants. Cytokine & Growth Factor Reviews. February 2022.
  4. WHO TAG-VE Risk Evaluation for SARS-CoV-2 Variant Under Monitoring: NB.1.8.1. World Health Organization. May 23, 2025.
  5. Variant Report 2025-05-21. Neherlab. May 2025.
  6. Tin A. New COVID Variant NB.1.8.1 Behind Surge in China, Now Setected in U.S. CBS News. May 23, 2025.

Tom Gavin

Fact-Checker

Tom Gavin joined Everyday Health as copy chief in 2022 after a lengthy stint as a freelance copy editor. He has a bachelor's degree in psychology from College of the Holy Cross.

Prior to working for Everyday Health, he wrote, edited, copyedited, and fact-checked for books, magazines, and digital content covering a range of topics, including women's health, lifestyle, recipes, restaurant reviews, travel, and more. His clients have included Frommer's, Time-Life, and Google, among others.

He lives in Brooklyn, New York, where he likes to spend his time making music, fixing too-old electronics, and having fun with his family and the dog who has taken up residence in their home.

Don Rauf

Author

Don Rauf has been a freelance health writer for over 12 years and his writing has been featured in HealthDay, CBS News, WebMD, U.S. News & World Report, Mental Floss, United Press International (UPI), Health, and MedicineNet. He was previously a reporter for DailyRx.com where he covered stories related to cardiology, diabetes, lung cancer, prostate cancer, erectile dysfunction, menopause, and allergies. He has interviewed doctors and pharmaceutical representatives in the U.S. and abroad.

He is a prolific writer and has written more than 50 books, including Lost America: Vanished Civilizations, Abandoned Towns, and Roadside Attractions. Rauf lives in Seattle, Washington.