People Who’ve Injected Drugs Deserve Hep C Treatment, Too
People Who Have Injected Drugs Deserve Hep C Treatment, Too
U ntil recently, most people diagnosed with hepatitis C were baby boomers, many of whom got the infection via a blood transfusion.
As of 2024, hepatitis C is mostly spread via needles, syringes, and other equipment, according to the Centers for Disease Control and Prevention (CDC). And, while the people who acquire the virus comprise a wide range of ages, millennials (born between 1981 and 1996) are particularly at risk.
Problem is, the people who are most likely to contract hep C are the least likely to have access to direct-acting antiviral medications, which can cure more than 95 percent of people with hepatitis C within 12 weeks, according to the World Health Organization.
“There are a lot of barriers to treatment for people who inject drugs,” says Erika Harrington, a pharmacist at Cleveland Clinic who leads a statewide program called Ohio Hepatitis Academic Mentorship Program (OH-HAMP), which trains physicians to recognize and treat hepatitis C. “But, actively using shouldn’t preclude them from treatment.” In fact, she adds, they may be the ideal candidates for treatment, as they’re likely to benefit most from it and also tend to be especially careful not to be reinfected once they’re cured.
These hurdles span nearly every part of the healthcare system, from doctors to insurance companies and the costs of the medications themselves.
Health Insurance Restrictions to Treatment
When the first direct-acting antivirals for hepatitis C were developed, in 2011, the price tag was steep. A single pill could cost $1,000, which added up to $84,000 for a 12-week course of treatment.
For this reason, says Harrington, many insurance companies imposed strict rules for who could be treated with the potentially lifesaving medication. Some required the person to have advanced liver disease before granting approval. Others required pre-authorization from a doctor, making it possible for a claim — and then the appeal — to be denied. Even if the company didn’t deny the claim, the red tape slowed down the treatment process, according to a study published in PLoS One.
These restrictions spanned the health insurance industry, but state Medicaid programs — which cover many people with substance use disorders — had the most limitations.
Even today, people who have private health insurance are more likely to be treated for hepatitis C than those who have Medicare or Medicaid. According to CDC statistics, someone with Medicaid is 46 percent less likely to receive timely treatment than someone with private insurance.
While many of these barriers have been removed over the years, some state Medicaid programs have yet to let go of sobriety requirements for people who inject drugs, says Harrington. “The view is that the patient has to be clean and sober in order to be eligible for treatment, and that’s backward thinking,” she explains.
In seven states, doctors have to counsel their patients about substance use issues before they can treat them. In three states, people have to abstain from alcohol or drugs for a period of time — usually six months — before they can receive treatment.
This, despite the fact that research shows people who inject drugs are just as likely to be cured of hepatitis C after taking antiviral medication as people who don’t inject drugs.
In fact, a study published in Clinical Infectious Diseases found that even when people who inject drugs miss some hep C medication doses or stop taking the treatment temporarily, they’re still likely to be cured of the virus.

Doctors May Not Treat Hepatitis C in People Who Inject Drugs
Given the high cost of antivirals, some doctors choose to deny hepatitis C treatment to people who inject drugs, because they believe their patients will be reinfected with the virus, according to a review published in 2021 in the International Journal of Drug Policy.
But, while rates of hep C are high among people who inject drugs — about 53 percent will contract the virus, according to the CDC — research shows that the reinfection rate is relatively low.
One review, published in Clinical Infectious Diseases, found that only about 15 percent of people who are considered at high risk for reinfection — including people who continue to inject drugs — actually get the virus again. Among people without high-risk behaviors, the reinfection rate was closer to 1 percent.
One reason for the low rates of reinfection, says Harrington, is that people who’ve been treated for hepatitis C are more careful about sharing needles or other equipment that might transmit the virus.
“They’ve been there, seen that, and they don’t want to go there again,” she says.
There are also ways to reduce the odds that someone will continue to use drugs after they’ve received a hepatitis C diagnosis, Harrington adds. “If we offer them mental health services and medications that can help reduce substance use disorder, we can cut the reinfection rate by about a third.”

Financial Help for Hepatitis C Medication
People without health insurance, or whose insurance companies have denied them treatment, may end up having to foot the entire cost of the medication. Even a generic hepatitis C antiviral can run as much as $24,000, according to the U.S. Department of Health and Human Services Office of Inspector General. These services and organizations can help people pay for hepatitis C medications:
- NeedyMeds is a nonprofit organization that helps people find financial assistance programs; coupons and rebates for medications; and free or low-cost clinics. They also offer a drug discount card that can shave up to 80 percent off the price of certain medications.
- Help-4-Hep is a nonprofit hotline that offers help finding financial assistance and free or low-cost clinics.
- Medicine Assistance Tool helps people enroll in patient assistance programs, which allows those who qualify to receive brand name medications from the drug manufacturer.
- Good Days is a nonprofit organization that helps qualifying people with their copays, often for a year or more.
- HealthWell Foundation is a nonprofit that helps qualifying people pay their premiums, deductibles, and copays.
- Simmons B et al. Risk of Late Relapse or Reinfection With Hepatitis C Virus After Achieving a Sustained Virological Response: A Systematic Review and Meta-Analysis. Clinical Infectious Diseases. March 2016.
- Frankova S et al. Therapy of Chronic Hepatitis C in People Who Inject Drugs: Focus on Adherence. Harm Reduction Journal. June 2021.
- Amoako A et. al. Patient and Provider Perceived Barriers and Facilitators to Direct Acting Antiviral Hepatitis C Treatment Among Priority Populations in High Income Countries: A Knowledge Synthesis. International Journal of Drug Policy. October 2021.
- Viral Hepatitis. Centers for Disease Control and Prevention. October 31, 2023.
- Thompson W et al. Vital Signs: Hepatitis C Treatment Among Insured Adults — United States, 2019–2020. Centers for Disease Control and Prevention. August 12, 2022.
- How Part D Plans’ Preference for Higher Cost Hepatitis C Drugs Affects Medicare Beneficiaries. U.S. Department of Health and Human Services Office of Inspector General.
- Javanbakht M et al. Will Prior Health Insurance Authorization for Medications Continue to Hinder Hepatitis C Treatment Delivery in the United States? Perspectives From Hepatitis C Treatment Providers in a Large Urban Healthcare System. PLoS One. November 2020.
- Hepatitis C. World Health Organization. July 18, 2023.
- Interview with Erika Harrington, Cleveland Clinic. March 2023.