The 9 Best Supplements for Anxiety and Our Recommendations for Relieving Anxiety Symptoms
Getting treatment can help you take charge of anxiety. Depending on how severe your anxiety is, some treatments can include lifestyle changes, medication, therapy, supplements, or a mix of these. If you have any concerns or questions about the best way to treat your anxiety, talk with a healthcare professional. They can help you figure out what treatment options could work best for you.
In many cases, there are supplements for anxiety that can help your body deal with stress, help promote calmness, or provide nutrients that you may not be getting enough of in your regular diet.
We consulted with Lisa Andrews, RD, founder of Sound Bites Nutrition in Cincinnati, and E.A. Stewart, RDN, a San Diego-based nutrition coach and food blogger at Spicy RD Nutrition, to help us find the best supplement options for someone coping with anxiety.
When to Consult Your Doctor?
Our Top Picks for the Best Supplements for Anxiety
- Best magnesium: Life Extension Calm-Mag
- Best vitamin D: Thorne Vitamin D Liquid
- Best L-theanine: Pure Encapsulations L-Theanine
- Best omega-3: Viva Naturals Triple-Strength Omega-3 Fish Oil
- Best multivitamin: Pure Encapsulations O.N.E. Multivitamin
- Best for sleep: Nutricost Valerian Root
- Best ashwagandha: Pure Encapsulations Ashwagandha
- Best passion flower: Nutricost Passion Flower Extract
- Best lemon balm: Double Wood Supplements Lemon Balm Tincture

Best Magnesium
Life Extension Calm-Mag
Pros
- Easy to adjust dosing
- This form of magnesium may benefit mental health
- Third-party tested
Cons
- May have a laxative effect
- May need to take multiple capsules, depending on your needs
Key Specs
- Key ingredient: Magnesium acetyl-taurate
- Type of supplement: Capsule
- Dosage: 45 milligrams (mg) per capsule
- Serving size: 1 capsule, 30 servings per bottle
Each capsule provides 45 mg of magnesium acetyl-taurate, which is around 11 percent of the daily value. We appreciate that the Life Extension brand does third-party testing on its supplements, and you can request a certificate of analysis for each lot.
You may need to take more than one capsule per day, though, depending on your personal magnesium needs. Also, be aware that magnesium can interfere with some medications.
Julie Kaur Kalair, MPH, RDN, a New York-based ayurvedic dietitian and founder of Good Food Karma, says, “Though magnesium does have a relaxing effect, that effect also extends to your digestive system.” This is why diarrhea may be a common side effect while taking a magnesium supplement. She also suggests checking your magnesium levels before taking a magnesium supplement to help better understand which dose is best for your needs.

Best Vitamin D
Thorne Vitamin D Liquid
Pros
- Third-party tested
- Adjustable dose
- Can easily be added to drinks or foods
- Reputable brand
- 600 servings per bottle
Cons
- Can be difficult and messy to measure
- May not help relieve some types of anxiety
Key Specs
- Key ingredient: Vitamin D
- Type of supplement: Liquid
- Dosage: 1,000 international units (IU) per two-drop serving
- Serving size: 2 drops, 600 servings per bottle
Each two-drop serving also provides 1,000 international units of vitamin D3, which is 125 percent of the daily value. Plus, since it’s a liquid supplement, the dosing can easily be adjusted depending on your needs and can be added to any drink or food.
In addition to third-party testing, Thorne does four rounds of in-house testing for ingredient purity and is a trusted supplement brand. Thorne collaborates with top research institutions like the National Institutes of Health, Cleveland Clinic, and Mayo Clinic for clinical trials with their supplements.

Best L-Theanine
Pure Encapsulations L-Theanine
Pros
- Free from major food allergens
- No fillers added
- Third-party tested
Cons
- Research isn’t as strong for L-theanine and anxiety
- Expensive
Key Specs
- Key ingredient: L-theanine
- Type of supplement: Capsule
- Dosage: 200 mg per capsule
- Serving size: 1 capsule, 60 capsules per bottle
A healthcare professional can help determine if L-theanine would be best for you, and they can also recommend an appropriate daily dosage. Stewart suggests that L-theanine may work best for anxiety related to stress management or sleep. But “research on L-theanine's impact on anxiety is mixed, and more research is needed,” she says.
Pure Encapsulations does third-party testing for ingredient purity in its supplements, and each capsule provides 200 mg of L-theanine. It’s also vegan, free from major food allergies, and doesn’t have any fillers or added ingredients.

Best Omega-3
Viva Naturals Triple-Strength Omega-3 Fish Oil
Pros
- Third-party tested
- International fish oil standards (IFOS)-certified
- Dosage is in line with research on anxiety
- Softgel capsules
Cons
- May cause fishy aftertaste
- Research is mixed on improving anxiety
- Can interfere with medications
Key Specs
- Key ingredient: Omega-3
- Type of supplement: Softgel
- Dosage: 2,250 mg per serving
- Serving Size: 2 softgels, 90 servings per bottle
If you’re thinking about taking an omega-3 supplement to help with anxiety, we suggest Viva Naturals Triple-Strength Omega-3. Each serving (two soft gels) provides a total of 2,250 mg, with 1,500 mg coming from EPA, a type of omega-3 that’s found in fish. This supplement is also third-party tested for ingredient accuracy and purity, and is tested for heavy metals — an important consideration for products that use fish oil.
Viva Naturals is IFOS-certified, meaning that the supplement is tested to ensure that the ingredients are accurate, free of contaminants, and are delivered fresh and not oxidized. A serving size of just two soft gels is pretty reasonable, considering the high dose of omega-3s you’ll get, but it may come with the side effect of fishy burps after taking it. Also, if you’re on any medications, speak with a healthcare professional first, as taking omega-3 supplements can interfere with medications.

Best Multivitamin
Pure Encapsulations O.N.E. Multivitamin
Pros
- Single capsule
- Vitamins in absorbable form
- Third-party tested
- Added antioxidants
Cons
- More research needed
- Missing some minerals like iron
Key Specs
- Key ingredient: Several different vitamins and minerals
- Type of supplement: Capsule
- Dosage: Varies based on nutrient
- Serving size: 1 capsule, 120 servings per bottle
The Pure Encapsulations O.N.E. Multivitamin stands out among multivitamin supplements, because it has vitamins and minerals in their most absorbable form, all in a single capsule. Each capsule provides over 100 percent of the daily value for vitamins A,D,E,K, and the B vitamins. It provides near or over 100 percent of the daily value for the minerals iodine, selenium, zinc, chromium, and molybdenum.
While these studies suggest that taking a multivitamin may help with anxiety, more research is still needed. Use of a multivitamin may help with anxiety if your diet is already lacking in several nutrients. But if your diet already provides what your body needs, you may see minimal improvements.
This multi doesn’t include iron, a nutrient that can be lacking for women or vegetarians. It also includes added antioxidants not found in other multivitamins, which could interfere with some medications. That’s why it’s a good idea to talk with a healthcare professional before taking any new vitamin supplements.

Best for Sleep
Nutricost Valerian Root
Pros
- Third-party tested
- Budget-friendly
- Vegetarian, non-GMO
Cons
- Specifically for anxiety that affects sleep; may not be helpful for other types
- May cause digestive upset for some people
Key Specs
- Key ingredient: Valerian root extract
- Type of supplement: Capsule
- Dosage: 1,000 mg per serving; equivalent to 4,000 mg of valerian root
- Serving size: 2 capsules, 60 servings per bottle
If a healthcare professional recommends that you take valerian root to help with sleep and anxiety, we suggest this supplement from Nutricost. Valerian root has been used for centuries as a sleep supplement that helps promote relaxation. So if your anxiety is interfering with your sleep, you might find this to be a helpful supplement.
“In Ayurveda, we do use valerian root, usually before bed to help support a restful sleep,” Kalair says. But she cautions that this supplement is only intended for short-term use, and you shouldn’t take valerian root indefinitely.
We appreciate that this supplement is third-party tested, non-GMO, and suitable for gluten-free and vegetarian diets. Each serving consists of two capsules, and there are 60 servings per bottle. It’s also one of the more-affordable options available.
Best Ashwagandha
Pure Encapsulations Ashwagandha
Pros
- Single-capsule serving
- Dose is in line with current research guidelines
- Third-party tested
Cons
- Recommended use only up to 3 months
- Can interact with medications
Key Specs
- Key ingredient: Ashwagandha
- Type of supplement: Capsule
- Dosage: 500 mg per serving
- Serving size: 1 capsule, 60 servings per bottle
We picked Pure Encapsulations Ashwagandha as our top-recommended ashwagandha supplement because it offers a 500-mg dose per one capsule serving — or in other words, a dose right in the middle of the NIH recommendation.
However, more research is needed to make a stronger recommendation. And before you try this supplement, talk with your doctor first.
Best Passionflower
Nutricost Passion Flower Extract
Pros
- Third-party tested
- Single capsule
- Minimal side effects for most people
Cons
- May not help with all types of anxiety
Key Specs
- Key ingredient: Passion flower extract
- Type of supplement: Capsule
- Dosage: 375 mg per serving; equivalent to 1,500 mg of passion flower
- Serving size: 1 capsule, 120 servings per bottle
Nutricost Passion Flower Extract tops our list as a passion flower supplement for anxiety, because it’s third-party tested and comes in a single-capsule serving size. Each capsule provides the equivalent of 1,500 mg of passion flower.
“Passion flower is an herb with calming effects that has been used, with great success, to manage anxiety. Its compounds are believed to increase levels of GABA, a neurotransmitter that helps reduce brain activity, promoting relaxation and decreasing anxiety,” says Vanessa Imus, RDN, owner of Integrated Nutrition for Weight Loss in Bothell, Washington.
Best Lemon Balm
Double Wood Supplements Lemon Balm Tincture
Pros
- Third-party tested
- Can be added to any drink or food
- Organic
- 120 servings per bottle
Cons
- Can interfere with some medications
- Harder to measure
Key Specs
- Key ingredient: Lemon balm
- Type of supplement: Tincture
- Dosage: 590 mg per 0.5 milliliter (mL) serving
- Serving size: 0.5 mL (about 15 drops), 120 servings per bottle
Double Wood Supplements Lemon Balm Tincture is an absorbable liquid that can be taken on its own or easily added to a drink or food. Double Wood also suggests adding these drops to a lemon-balm tea for an extra boost. This supplement is third-party tested, and the testing results and certificate of analysis are available on the company’s website.
Talk with a healthcare professional before taking lemon balm. “It should be used with caution in people with glaucoma and thyroid conditions. Lemon balm may also reduce the effectiveness of SSRIs,” says Stewart.
Comparison Table
How We Selected the Best Supplements for Anxiety
As a registered dietitian with extensive experience in writing about supplements, I have spent many hours looking at the specific research around anxiety and supplements. That helped me build this list of the best supplements for anxiety, as supported by research. Plus, we prioritized supplement brands based on their reputation for including high-quality ingredients, the offered dosage per serving, and verified third-party testing.
I also consulted with four dietitians, including:
- Lisa Andrews, RD
- E.A. Stewart, RDN
- Julie Kaur Kalair, MPH, RDN
- Vanessa Imus, RDN
Together, we used our insight and expertise to select products and help you find ones that meet a range of needs for helping manage anxiety under the guidance of a healthcare professional.
What to Look for When Buying Supplements for Anxiety
Knowing what supplement for anxiety will work best for you will depend on the possible cause of your anxiety. Are you looking to fill in any nutritional gaps in your diet? Help your body better deal with stress? Or help promote a stronger sense of calm?
You’ll also want to consider any medications that you’re taking that might interact with a supplement, any underlying medical conditions, or if you are pregnant or breastfeeding. One of the most important steps you can take is to talk with a healthcare professional first before starting a new supplement.
Beyond these initial considerations, we recommend the following when choosing a supplement:
- Third-Party Testing One of our top priorities when recommending any supplement is to confirm that it is third-party tested. “Third-party testing means the supplement has been independently tested by an outside agency for quality and safety, and validates that the product contains the ingredients listed on its label,” says Andrews.
Supplements can display a logo from NSF, USP, or other certifiers showing they are third-party tested. But even if a supplement bottle doesn’t have these logos, it may still be third-party tested. Check the company website or ask a healthcare professional if you’re not sure. - Research The supplements we recommend all have some research supporting that the key ingredients may help with some types of anxiety. However, since research is always ongoing, larger studies are often recommended to verify the effectiveness of some ingredients. Stewart recommends that you “review efficacy studies to see what human-research studies have been conducted on the supplement, particularly at what dosage. Many times, I have clients taking supplements backed by research but at a higher dosage than what they are taking.”
- Medication Interactions Each supplement may interfere with certain medications, and it can be tough to know for sure which supplements will or won’t interact negatively with medication. So, if you’re taking medication, it’s important to research the supplement yourself and talk with a trusted healthcare professional before taking it.
What Is Anxiety and How Does It Present in Your Body?
Are Anxiety Supplements Safe and FDA-Approved?
It’s important to research a supplement and the main ingredient, and to speak to a healthcare professional to learn if it’s safe for you. A supplement label may make some impressive health claims, but these statements may not always be completely accurate or backed up by legitimate research.
FAQs
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Holly Klamer
Author
Holly has been writing about nutrition, fitness, and health since 2011, and she has been writing and editing content for Everyday Health since 2025. Prior to this, she worked as a nutrition editor at Health.
She is also a registered dietitian who has worked in corporate wellness, sports nutrition, and as a restaurant consultant for menu development.
She has a bachelor's and master's degree in nutrition and exercise science from Colorado State University. She ran track and cross country at Central Michigan University and still loves to run and stay active in her free time.

Angela D. Harper, MD
Medical Reviewer
Angela D. Harper, MD, is in private practice at Columbia Psychiatric Associates in South Carolina, where she provides evaluations, medication management, and psychotherapy for adults.
A distinguished fellow of the American Psychiatric Association, Dr. Harper has worked as a psychiatrist throughout her career, serving a large number of patients in various settings, including a psychiatric hospital on the inpatient psychiatric and addiction units, a community mental health center, and a 350-bed nursing home and rehab facility. She has provided legal case consultation for a number of attorneys.
Harper graduated magna cum laude from Furman University with a bachelor's degree and cum laude from the University of South Carolina School of Medicine, where she also completed her residency in adult psychiatry. During residency, she won numerous awards, including the Laughlin Fellowship from the American College of Psychiatrists, the Ginsberg Fellowship from the American Association of Directors of Psychiatric Residency Training, and resident of the year and resident medical student teacher of the year. She was also the member-in-training trustee to the American Psychiatric Association board of trustees during her last two years of residency training.
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