The 9 Best Supplements for Anxiety and Our Recommendations for Relieving Anxiety Symptoms 

The 9 Best Supplements for Anxiety and Our Recommendations for Relieving Anxiety Symptoms

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Anxiety affects millions of Americans every year, and it’s one of the most common mental health conditions.

Around 31 percent of adults in the United States may experience an anxiety disorder at some point in life.

 Beyond just managing anxiety in the moment, it’s important to treat and manage it long-term as well. That’s because ongoing anxiety is linked with lower quality of life and depression.

Getting treatment can help you take charge of anxiety. Depending on how severe your anxiety is, some treatments can include lifestyle changes, medication, therapy, supplements, or a mix of these. If you have any concerns or questions about the best way to treat your anxiety, talk with a healthcare professional. They can help you figure out what treatment options could work best for you.

In many cases, there are supplements for anxiety that can help your body deal with stress, help promote calmness, or provide nutrients that you may not be getting enough of in your regular diet.

We consulted with Lisa Andrews, RD, founder of Sound Bites Nutrition in Cincinnati, and E.A. Stewart, RDN, a San Diego-based nutrition coach and food blogger at Spicy RD Nutrition, to help us find the best supplement options for someone coping with anxiety.

When to Consult Your Doctor?

Andrews says that if you’re already taking medications, you should talk to a healthcare professional before starting supplements to treat anxiety. Some supplements may interact with (meaning affect) your medications. What’s more, Stewart says that while anxiety supplements may be safe to take in the short term, the long-term safety is unknown for many common supplements. So it’s best to speak with a healthcare professional if you’re seeking long-term support. Also talk with your doctor if you notice any negative side effects after taking a supplement.

Our Top Picks for the Best Supplements for Anxiety

Best Magnesium

Life Extension Calm-Mag

Pros

  • Easy to adjust dosing
  • This form of magnesium may benefit mental health
  • Third-party tested

Cons

  • May have a laxative effect
  • May need to take multiple capsules, depending on your needs

Key Specs

  • Key ingredient: Magnesium acetyl-taurate
  • Type of supplement: Capsule
  • Dosage: 45 milligrams (mg) per capsule
  • Serving size: 1 capsule, 30 servings per bottle
If you’re looking for a magnesium supplement for anxiety, we recommend Life Extension Calm-Mag. It has a specific form of magnesium called magnesium acetyl-taurate that may be especially helpful for mental health and neuron signaling in the brain.

Magnesium is an important mineral that’s involved in over 300 functions in your body, including those that help manage anxiety. Research also shows a magnesium deficiency may increase the risk for anxiety, depression, or cognitive decline.

So, taking a magnesium supplement may help manage anxiety, especially if you aren’t getting enough in your regular diet.

Each capsule provides 45 mg of magnesium acetyl-taurate, which is around 11 percent of the daily value. We appreciate that the Life Extension brand does third-party testing on its supplements, and you can request a certificate of analysis for each lot.

You may need to take more than one capsule per day, though, depending on your personal magnesium needs. Also, be aware that magnesium can interfere with some medications.

Julie Kaur Kalair, MPH, RDN, a New York-based ayurvedic dietitian and founder of Good Food Karma, says, “Though magnesium does have a relaxing effect, that effect also extends to your digestive system.” This is why diarrhea may be a common side effect while taking a magnesium supplement. She also suggests checking your magnesium levels before taking a magnesium supplement to help better understand which dose is best for your needs.

Best Vitamin D

Thorne Vitamin D Liquid

$19 at Walmart
$14Now -36% Off

Pros

  • Third-party tested
  • Adjustable dose
  • Can easily be added to drinks or foods
  • Reputable brand
  • 600 servings per bottle

Cons

  • Can be difficult and messy to measure
  • May not help relieve some types of anxiety

Key Specs

  • Key ingredient: Vitamin D
  • Type of supplement: Liquid
  • Dosage: 1,000 international units (IU) per two-drop serving
  • Serving size: 2 drops, 600 servings per bottle
Vitamin D does many important jobs in your body, including playing a role in your brain health and overall mood. Low levels of vitamin D are also linked with increased symptoms of anxiety and depression.

 We like Thorne Vitamin D Liquid because it is NSF Contents Certified, meaning it’s third party–tested for ingredient accuracy and purity.

Each two-drop serving also provides 1,000 international units of vitamin D3, which is 125 percent of the daily value. Plus, since it’s a liquid supplement, the dosing can easily be adjusted depending on your needs and can be added to any drink or food.

Taking a vitamin D supplement if you’re deficient may help treat anxiety, too. One study concluded that taking a vitamin D supplement for six months can help improve anxiety symptoms for those with low levels of vitamin D.

Still, it’s best to check your levels of vitamin D with a healthcare professional first. They can help figure out what dose (if any) best suits your needs. If you’re not deficient, taking a vitamin D supplement probably won’t help your anxiety.

In addition to third-party testing, Thorne does four rounds of in-house testing for ingredient purity and is a trusted supplement brand. Thorne collaborates with top research institutions like the National Institutes of Health, Cleveland Clinic, and Mayo Clinic for clinical trials with their supplements.

Best L-Theanine

Pure Encapsulations L-Theanine

$48.80 at Amazon
$61Now 20% Off

Pros

  • Free from major food allergens
  • No fillers added
  • Third-party tested

Cons

  • Research isn’t as strong for L-theanine and anxiety
  • Expensive

Key Specs

  • Key ingredient: L-theanine
  • Type of supplement: Capsule
  • Dosage: 200 mg per capsule
  • Serving size: 1 capsule, 60 capsules per bottle
We recommend Pure Encapsulations L-theanine if you’re looking to add this potentially anxiety-lowering amino acid to your regular diet. L-theanine occurs naturally in green tea and contributes to many of the tea’s health benefits.

 A research review found that taking between 200 to 400 mg per day of L-theanine for up to eight weeks was safe and lowered anxiety in study participants.

A healthcare professional can help determine if L-theanine would be best for you, and they can also recommend an appropriate daily dosage. Stewart suggests that L-theanine may work best for anxiety related to stress management or sleep. But “research on L-theanine's impact on anxiety is mixed, and more research is needed,” she says.

Pure Encapsulations does third-party testing for ingredient purity in its supplements, and each capsule provides 200 mg of L-theanine. It’s also vegan, free from major food allergies, and doesn’t have any fillers or added ingredients.

viva naturals omega3 fish oil

Best Omega-3

Viva Naturals Triple-Strength Omega-3 Fish Oil

Pros

  • Third-party tested
  • International fish oil standards (IFOS)-certified
  • Dosage is in line with research on anxiety
  • Softgel capsules

Cons

  • May cause fishy aftertaste
  • Research is mixed on improving anxiety
  • Can interfere with medications

Key Specs

  • Key ingredient: Omega-3
  • Type of supplement: Softgel
  • Dosage: 2,250 mg per serving
  • Serving Size: 2 softgels, 90 servings per bottle

If you’re thinking about taking an omega-3 supplement to help with anxiety, we suggest Viva Naturals Triple-Strength Omega-3. Each serving (two soft gels) provides a total of 2,250 mg, with 1,500 mg coming from EPA, a type of omega-3 that’s found in fish. This supplement is also third-party tested for ingredient accuracy and purity, and is tested for heavy metals — an important consideration for products that use fish oil.

Omega-3 supplements may offer many health benefits, including help with treating anxiety. A research review concluded that omega-3 supplements may help with anxiety, specifically when the dose is at least 2,000 mg per day.

Viva Naturals is IFOS-certified, meaning that the supplement is tested to ensure that the ingredients are accurate, free of contaminants, and are delivered fresh and not oxidized. A serving size of just two soft gels is pretty reasonable, considering the high dose of omega-3s you’ll get, but it may come with the side effect of fishy burps after taking it. Also, if you’re on any medications, speak with a healthcare professional first, as taking omega-3 supplements can interfere with medications.

Best Multivitamin

Pure Encapsulations O.N.E. Multivitamin

$86 at Walmart
$70.80Now -21% Off

Pros

  • Single capsule
  • Vitamins in absorbable form
  • Third-party tested
  • Added antioxidants

Cons

  • More research needed
  • Missing some minerals like iron

Key Specs

  • Key ingredient: Several different vitamins and minerals
  • Type of supplement: Capsule
  • Dosage: Varies based on nutrient
  • Serving size: 1 capsule, 120 servings per bottle

The Pure Encapsulations O.N.E. Multivitamin stands out among multivitamin supplements, because it has vitamins and minerals in their most absorbable form, all in a single capsule. Each capsule provides over 100 percent of the daily value for vitamins A,D,E,K, and the B vitamins. It provides near or over 100 percent of the daily value for the minerals iodine, selenium, zinc, chromium, and molybdenum.

One study showed that taking a multivitamin, compared with a “fake” pill called a placebo, significantly helped lower anxiety in college students when they took one for 30 days.

Another study also found that, compared with a placebo, taking a multivitamin daily for eight weeks significantly lowered self-reported depression and anxiety scores in men 50 to 69 years old.

While these studies suggest that taking a multivitamin may help with anxiety, more research is still needed. Use of a multivitamin may help with anxiety if your diet is already lacking in several nutrients. But if your diet already provides what your body needs, you may see minimal improvements.

This multi doesn’t include iron, a nutrient that can be lacking for women or vegetarians. It also includes added antioxidants not found in other multivitamins, which could interfere with some medications. That’s why it’s a good idea to talk with a healthcare professional before taking any new vitamin supplements.

Best for Sleep

Nutricost Valerian Root

$9.08 at Amazon
$11.95Now 24% Off

Pros

  • Third-party tested
  • Budget-friendly
  • Vegetarian, non-GMO

Cons

  • Specifically for anxiety that affects sleep; may not be helpful for other types
  • May cause digestive upset for some people

Key Specs

  • Key ingredient: Valerian root extract
  • Type of supplement: Capsule
  • Dosage: 1,000 mg per serving; equivalent to 4,000 mg of valerian root
  • Serving size: 2 capsules, 60 servings per bottle

If a healthcare professional recommends that you take valerian root to help with sleep and anxiety, we suggest this supplement from Nutricost. Valerian root has been used for centuries as a sleep supplement that helps promote relaxation. So if your anxiety is interfering with your sleep, you might find this to be a helpful supplement.

“In Ayurveda, we do use valerian root, usually before bed to help support a restful sleep,” Kalair says. But she cautions that this supplement is only intended for short-term use, and you shouldn’t take valerian root indefinitely.

Also, be aware that research on valerian root and anxiety is mixed. The supplement is considered safe and well-tolerated for most people, but some may have mild digestive side effects.

We appreciate that this supplement is third-party tested, non-GMO, and suitable for gluten-free and vegetarian diets. Each serving consists of two capsules, and there are 60 servings per bottle. It’s also one of the more-affordable options available.

Best Ashwagandha

Pure Encapsulations Ashwagandha

Pros

  • Single-capsule serving
  • Dose is in line with current research guidelines
  • Third-party tested

Cons

  • Recommended use only up to 3 months
  • Can interact with medications

Key Specs

  • Key ingredient: Ashwagandha
  • Type of supplement: Capsule
  • Dosage: 500 mg per serving
  • Serving size: 1 capsule, 60 servings per bottle
Ashwagandha is an adaptogen that may help your body handle stress and lower anxiety. In fact, The National Institute for Health (NIH) suggests, based on current research, a daily dose of 300 to 600 mg of ashwagandha root as a treatment for generalized anxiety disorder.

We picked Pure Encapsulations Ashwagandha as our top-recommended ashwagandha supplement because it offers a 500-mg dose per one capsule serving — or in other words, a dose right in the middle of the NIH recommendation.

However, more research is needed to make a stronger recommendation. And before you try this supplement, talk with your doctor first.

Kalair recommends cycling on and off ashwagandha under the supervision of a healthcare professional. “In Ayurveda, ashwagandha is given with great care. It is not given to everyone, and [it’s] not typically our first line of treatment,” she says. The NIH also recommends using ashwagandha for only a limited amount of time. Most research studies suggest ashwagandha is safe for most people for up to three months.


It is important to caution any new users to ashwagandha that it has been shown to interfere with several different medications and may not be recommended while pregnant, breastfeeding, or for thyroid, liver, or prostate issues.

Best Passionflower

Nutricost Passion Flower Extract

Pros

  • Third-party tested
  • Single capsule
  • Minimal side effects for most people

Cons

  • May not help with all types of anxiety

Key Specs

  • Key ingredient: Passion flower extract
  • Type of supplement: Capsule
  • Dosage: 375 mg per serving; equivalent to 1,500 mg of passion flower
  • Serving size: 1 capsule, 120 servings per bottle

Nutricost Passion Flower Extract tops our list as a passion flower supplement for anxiety, because it’s third-party tested and comes in a single-capsule serving size. Each capsule provides the equivalent of 1,500 mg of passion flower.

“Passion flower is an herb with calming effects that has been used, with great success, to manage anxiety. Its compounds are believed to increase levels of GABA, a neurotransmitter that helps reduce brain activity, promoting relaxation and decreasing anxiety,” says Vanessa Imus, RDN, owner of Integrated Nutrition for Weight Loss in Bothell, Washington.

A research review concluded that passion flower is a safe and effective supplement to help reduce stress, anxiety, and depressive-like behaviors.

 “Passion flower has shown some efficacy for generalized anxiety disorder (GAD) and improvement in sleep quality,” says Stewart. Also, one study found that taking passion flower in addition to antidepressant medication helped study participants improve some symptoms of GAD.

Best Lemon Balm

Double Wood Supplements Lemon Balm Tincture

Pros

  • Third-party tested
  • Can be added to any drink or food
  • Organic
  • 120 servings per bottle

Cons

  • Can interfere with some medications
  • Harder to measure

Key Specs

  • Key ingredient: Lemon balm
  • Type of supplement: Tincture
  • Dosage: 590 mg per 0.5 milliliter (mL) serving
  • Serving size: 0.5 mL (about 15 drops), 120 servings per bottle

Double Wood Supplements Lemon Balm Tincture is an absorbable liquid that can be taken on its own or easily added to a drink or food. Double Wood also suggests adding these drops to a lemon-balm tea for an extra boost. This supplement is third-party tested, and the testing results and certificate of analysis are available on the company’s website.

Lemon balm is a plant that may have beneficial effects on brain health. “Lemon balm may improve anxiety by increasing GABA in the brain,” says Stewart. A research review found that lemon balm may be effective at improving anxiety and depressive symptoms, making it a potentially helpful supplement to treat both types of symptoms.

Still, the researchers say that larger studies are needed to confirm this benefit.

Talk with a healthcare professional before taking lemon balm. “It should be used with caution in people with glaucoma and thyroid conditions. Lemon balm may also reduce the effectiveness of SSRIs,” says Stewart.

Comparison Table

Superlative
Key ingredient
Type of Supplement
Serving Size
Best Magnesium
Magnesium acetyl-taurate
Capsule
1 capsule
Best Vitamin D
Vitamin D
Liquid
2 drops
Best L-Theanine
L-theanine
Capsule
1 to 2 per day
Best Multivitamin
Vitamins, some minerals, added antioxidants
Capsule
1 capsule
Best for Sleep
Valerian root extract
Capsule
2 capsules
Best Ashwagandha
Ashwagandha extract
Capsule
1 capsule
Best Passion Flower
Passion flower extract
Capsule
1 capsule
Best Lemon Balm
Lemon balm
Tincture
About 15 drops

How We Selected the Best Supplements for Anxiety

As a registered dietitian with extensive experience in writing about supplements, I have spent many hours looking at the specific research around anxiety and supplements. That helped me build this list of the best supplements for anxiety, as supported by research. Plus, we prioritized supplement brands based on their reputation for including high-quality ingredients, the offered dosage per serving, and verified third-party testing.

I also consulted with four dietitians, including:

  • Lisa Andrews, RD
  • E.A. Stewart, RDN
  • Julie Kaur Kalair, MPH, RDN
  • Vanessa Imus, RDN

Together, we used our insight and expertise to select products and help you find ones that meet a range of needs for helping manage anxiety under the guidance of a healthcare professional.

What to Look for When Buying Supplements for Anxiety

Knowing what supplement for anxiety will work best for you will depend on the possible cause of your anxiety. Are you looking to fill in any nutritional gaps in your diet? Help your body better deal with stress? Or help promote a stronger sense of calm?

You’ll also want to consider any medications that you’re taking that might interact with a supplement, any underlying medical conditions, or if you are pregnant or breastfeeding. One of the most important steps you can take is to talk with a healthcare professional first before starting a new supplement.

Beyond these initial considerations, we recommend the following when choosing a supplement:

  • Third-Party Testing One of our top priorities when recommending any supplement is to confirm that it is third-party tested. “Third-party testing means the supplement has been independently tested by an outside agency for quality and safety, and validates that the product contains the ingredients listed on its label,” says Andrews. 

    Supplements can display a logo from NSF, USP, or other certifiers showing they are third-party tested. But even if a supplement bottle doesn’t have these logos, it may still be third-party tested. Check the company website or ask a healthcare professional if you’re not sure.
  • Research The supplements we recommend all have some research supporting that the key ingredients may help with some types of anxiety. However, since research is always ongoing, larger studies are often recommended to verify the effectiveness of some ingredients. Stewart recommends that you “review efficacy studies to see what human-research studies have been conducted on the supplement, particularly at what dosage. Many times, I have clients taking supplements backed by research but at a higher dosage than what they are taking.”
  • Medication Interactions Each supplement may interfere with certain medications, and it can be tough to know for sure which supplements will or won’t interact negatively with medication. So, if you’re taking medication, it’s important to research the supplement yourself and talk with a trusted healthcare professional before taking it.

What Is Anxiety and How Does It Present in Your Body?

Anxiety is a heightened state of nervousness or worry that can present in many different ways. Some common symptoms are insomnia, rapid heart rate, nausea, changes in digestion (like stomachache or diarrhea), tremors, restlessness, or feeling on edge or irritable.

Anyone can feel anxious at times. But when these symptoms start interfering with your everyday life or feeling out of your control, it’s a good idea to get treatment from a professional.

Are Anxiety Supplements Safe and FDA-Approved?

Supplements are not regulated in the same way that medications are, which is why choosing a third-party tested supplement is important. The U.S. Food and Drug Administration (FDA) regulates supplement manufacturing and labeling.

A third-party tested supplement is another layer of safety to ensure that the supplement contains the right ingredients and amounts without having any unwanted, unsafe ingredients.

It’s important to research a supplement and the main ingredient, and to speak to a healthcare professional to learn if it’s safe for you. A supplement label may make some impressive health claims, but these statements may not always be completely accurate or backed up by legitimate research.

FAQs

Can poor nutrition cause me to feel anxious?
While diet may not be the only factor for feeling anxious, it can play a role. “A well-balanced diet can be a game-changer for anxiety management by helping with blood-sugar balance and ensuring your body gets all the necessary nutrients,” says Stewart. “It’s crucial to ensure you’re not lacking in any nutrients, including vitamin D, B vitamins (especially B12, B6, and folate), magnesium, and omega-3 fats. Equally important is getting the right balance of macronutrients — protein, carbohydrates, and fat — throughout the day.”
Many natural supplements (i.e. plants or herbs) may help with anxiety. Some of the main ones include valerian root, lemon balm, L-theanine, and passion flower. Ashwagandha is another natural supplement that may also help with anxiety. Knowing which natural supplement may work best for you depends on your symptoms and whether you take any medications that these supplements may interfere with.  
While no single food can automatically heal anxiety, a variety of healthy foods may help support mental health. But it may take time to feel the possible good effects of these diet changes on your mental health. “Foods that positively impact the gut microbiome may have a role in treating anxiety, as serotonin (a feel-good hormone) is produced in the gut,” says Andrews. “Fermented foods and beverages such as kombucha, kefir, kimchi, sauerkraut, and yogurt are beneficial for gut health.”

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Holly Klamer

Holly Klamer

Author

Holly has been writing about nutrition, fitness, and health since 2011, and she has been writing and editing content for Everyday Health since 2025. Prior to this, she worked as a nutrition editor at Health.

She is also a registered dietitian who has worked in corporate wellness, sports nutrition, and as a restaurant consultant for menu development.

She has a bachelor's and master's degree in nutrition and exercise science from Colorado State University. She ran track and cross country at Central Michigan University and still loves to run and stay active in her free time.

Angela-Harper-bio

Angela D. Harper, MD

Medical Reviewer

Angela D. Harper, MD, is in private practice at Columbia Psychiatric Associates in South Carolina, where she provides evaluations, medication management, and psychotherapy for adults.  

A distinguished fellow of the American Psychiatric Association, Dr. Harper has worked as a psychiatrist throughout her career, serving a large number of patients in various settings, including a psychiatric hospital on the inpatient psychiatric and addiction units, a community mental health center, and a 350-bed nursing home and rehab facility. She has provided legal case consultation for a number of attorneys.

Harper graduated magna cum laude from Furman University with a bachelor's degree and cum laude from the University of South Carolina School of Medicine, where she also completed her residency in adult psychiatry. During residency, she won numerous awards, including the Laughlin Fellowship from the American College of Psychiatrists, the Ginsberg Fellowship from the American Association of Directors of Psychiatric Residency Training, and resident of the year and resident medical student teacher of the year. She was also the member-in-training trustee to the American Psychiatric Association board of trustees during her last two years of residency training.

Harper volunteered for a five-year term on her medical school's admission committee, has given numerous presentations, and has taught medical students and residents. She currently supervises a nurse practitioner. She is passionate about volunteering for the state medical board's medical disciplinary commission, on which she has served since 2015.

She and her husband are avid travelers and have been to over 55 countries and territories.

Daniel Oakley

Fact-Checker

Daniel Oakley is a journalist, editor, and fact-checker. He has written, edited, taught, and produced media for Dow Jones, S&P Global, IHS Markit, Third Coast Studios Magazine, and 826 National.

Oakley's path has always been a health-and-wellness-focused one. A competitive triathlete and racing fundraiser for the Leukemia and Lymphoma Society, he also spends summer weekends as an ISA-certified surf instructor and Red Cross professional water rescuer with Laru Beya Collective in Rockaway Beach, which helps kids master and delight in their own backyard — the ocean. It has taught Oakley that “optimizing body and mind” flourishes precisely at the wellspring of community.

Steven Rowe

Steven Rowe

Editor

Steven Rowe is a New York City–based writer and editor with over six years of experience writing about mental health, men's health, parenting, and products.

His work has been published by Healthline, Psych Central, Health, Verywell, Parents, InStyle, Greatist, Romper, Inverse, Bustle, Mic, and RetailMeNot. He also worked as an editor at Healthline and a constant strategist and update writer at Verywell. Prior to becoming a writer, he also worked at Pace University in continuing education.

He has a degree in psychology from Pepperdine University and a master’s from Columbia School of the Arts. When he's not writing, you can find him hiking in the woods with his family and rescue beagle.

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