10 Surprising Health Benefits of B Complex Vitamins

10 Surprising Health Benefits of B Vitamins

10 Surprising Health Benefits of B Vitamins
Adobe Stock; Everyday Health

Note: The U.S. Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns.

Often overshadowed in the vitamin aisle, B vitamins power some of your body’s most essential functions, from boosting brain health to preventing disease. There are eight different types — known collectively as B-complex vitamins — and they help your body use energy and prevent a wide variety of health conditions.

B vitamins are found in food or can be taken as supplements, such as tinctures, capsules, or gummies, either as individual vitamins or as a B complex. Regularly consuming enough of them from food or supplements may unlock unexpected health benefits. Here’s what to know.

What Are B-Complex Vitamins?

B vitamins are a group of water-soluble nutrients (meaning they aren’t stored in the body and should be consumed every day) that play essential roles in well-being, from mood regulation to cardiovascular health. There are eight different types:

B-complex vitamins are found in a wide variety of foods, including poultry, meat, fish, dairy products, legumes, and vegetables.

Taking any one of the B vitamins for a long period of time can result in an imbalance of other important B vitamins, so a B-complex vitamin, which includes all the B vitamins, may be the best general supplementation option, after you’ve spoken with your doctor to make sure you’re a good candidate to take this supplement. Here’s how B vitamins may impact some common health concerns and conditions.

1. Can Reduce Risk of Anemia

Anemia affects an estimated three million people in the United States, and it comes with symptoms like fatigue, constipation, weight loss, loss of appetite, rash, shortness of breath, diarrhea, tingling or burning of hands or feet, cracked lips or mouth sores, and mood changes.

This condition is linked to low levels of vitamin B12, which may happen if you follow a vegan or vegetarian diet, since any sources of this vitamin are animal-based.

“When the body doesn’t get enough vitamin B12, it can’t make enough red blood cells, or it produces abnormally large ones that don’t function correctly,” says Brynna Connor, MD, a family medicine physician based in Austin, Texas. “This leads to a type of anemia called vitamin B12 deficiency anemia.”

Supplementing with vitamin B12 may help correct this deficiency. Pills, capsules, gummies, and other forms or B12 are available, and if you have anemia, your doctor can make recommendations about what kind and how much you should take, if necessary.

Or, to get more B12 in your diet, you can eat nutrient dense foods containing it, such as dairy products, fish, meat, and — in particular — beef liver and clams. This type of vitamin B can also be found in fortified items like breakfast cereals (which should be low in sugar) and nutritional yeast.

2. May Help Prevent Heart Disease and Stroke

Dr. Connor says that there are three types of B vitamins — B6, B9, and B12 — that play an important role in the prevention of heart disease and stroke.

“They do this by aiding in the reduction of homocysteine, which is a natural substance in your blood that comes from the breakdown of protein,” explains Connor. She says that the body does require some homocysteine, but too much can be harmful. “Studies have shown that higher levels of homocysteine are linked to an increased risk of heart disease and stroke, due to potential damage to the blood vessel lining and blood clots.”

Not all research is consistent on the connection between B vitamins and stroke prevention. A 2024 systematic review and meta-analysis in China of more than 76,000 people found folic acid combined with vitamin B12 and vitamin B6 supplementation significantly reduced the risk of stroke.

However, older research on more than 8,000 people found that B vitamin supplementation was no more effective than a placebo for stroke prevention.

If you’d like to explore the possibility of B vitamins for cardiovascular health, ask your doctor. According to Venuka Wick, MD, an assistant clinical professor in the department of family medicine at University of Washington Medicine in Seattle, it’s best to only take supplements under the guidance of a healthcare provider, as too much of certain vitamins can be harmful.

Illustrative graphic titled Health Benefits of B Vitamins shows may lower risk of heart disease/stroke, may help protect against anemia, may boost immune function, may help protect against dementia. Everyday Health
Everyday Health

3. May Support Immune Function

“The B team shows up big for your immune system,” says Bess Berger, RD, a nutritionist in Teaneck, New Jersey. Vitamin B6 helps your body make antibodies and keeps infection-fighting white blood cells in tip-top shape.

Meanwhile, vitamin B2, also known as riboflavin, produces powerful antioxidant activity to help the immune system function properly.

 Antioxidants have the potential to destroy free radicals, unstable molecules that create inflammation.

“B2 may also improve the body’s ability to produce antibodies, which are proteins that help fight infections and protect against future infections,” says Dr. Wick. She notes, however, that more research is needed to fully understand the impact of vitamin B2 on immune function.

4. May Relieve Migraine

People who experience this type of headache may find some relief in vitamin B2 (riboflavin).

“Clinical studies have indicated that taking high doses of riboflavin (typically around 400 milligrams per day) can reduce the number and duration of migraine attacks,” says Connor.

 The research is strong enough that riboflavin is considered a possible natural treatment for migraine.

One potential reason this works, Connor says, has to do with how cells produce energy. “Some researchers believe migraines may be partly caused by problems in the mitochondria, and when mitochondria don’t function properly, it may lead to changes in brain activity that trigger migraines,” she explains. Riboflavin improves mitochondrial function, potentially preventing migraines before they begin.

5. May Stave Off Dementia

“Studies link low levels of B vitamins, especially B12, B6, and folate (B9), with higher risks of cognitive decline and dementia,” says Berger. One meta-analysis of 95 studies, for example, concluded that taking vitamin B supplements reduced cognitive decline, and lower levels of folate were associated with higher risk of dementia.

6. May Prevent Beriberi

Too little vitamin B1 in your diet causes a condition called beriberi, a disease that affects the heart, digestive system, and the nervous system. Vitamin B1, found in foods like whole-grain cereals, yeast, beans, nuts, and meats, plays a major role in metabolizing food into energy.

Beriberi is rare in the United States, but it can be diagnosed in people who are malnourished, as well as in those who are heavy alcohol drinkers. (Connor says heavy alcohol consumption can interfere with the body’s ability to absorb vitamin B1.) Symptoms of beriberi include difficulty walking, loss of sensation in the hands and feet, and paralysis of the lower legs — and it may even lead to congestive heart failure.

7. May Regulate Hormone Levels

Vitamin B5 (pantothenic acid) is a key nutrient for sex and stress-related hormones produced in the adrenal glands, which are the small glands that sit atop the kidneys.

“B5 helps your adrenal glands crank out stress hormones like cortisol and makes sure you’ve got enough building blocks to produce sex hormones [like estrogen and testosterone],” Berger says. However, more human studies are needed to confirm whether supplementing with B5 might improve adrenal function.

The possible hormone benefits of B vitamins continue with vitamin B6, which one small pilot study suggests may alleviate premenstrual syndrome and premenstrual dysphoric disorder (a condition that involves severe hormonal mood swings).

Additionally, vitamin B12 and folate also pitch in by supporting the process of methylation. “This is a fancy word for turning genes on and off, including ones that influence hormone production,” Berger says. Some studies have shown that the methylation process may be involved in the development or prevention of conditions like type 2 diabetes.

8. May Support Healthy Babies in Utero

There’s good reason why vitamin B9, also called folic acid or folate, is a top ingredient in prenatal vitamins, and taking one comes highly recommended by the American College of Obstetrics and Gynecology.

For babies in utero, folic acid can help prevent major birth defects of the brain (anencephaly) and spine (spina bifida).

Plus, women’s personal B9 needs increase during pregnancy, Connor says, making supplementation a good idea during this stage of life. Folic acid also passes through breast milk.

For these reasons, the National Institutes of Health recommend that teens and adults get 400 micrograms daily, breastfeeding mothers should get 500 micrograms a day, and pregnant teens and women should get 600 micrograms a day.

Talk with your healthcare providers about any dietary supplements you may need to take while pregnant.

9. May Boost Skin Health

“Topical vitamin B3 (niacin) has been shown to improve skin barrier function and reduce inflammation, which may help improve conditions such as acne, eczema, and rosacea,” says Wick.

 Niacinamide is a topical form of vitamin B3. Experts say it helps build keratin, a protein that maintains skin health. It’s also been shown to ease inflammation and make skin stronger, smoother, and brighter.

10. May Help Heal Mouth Sores

People who are deficient in B vitamins can produce abnormally large red blood cells that don’t function correctly, which can lead to a host of symptoms, including mouth lesions. One meta-analysis of more than 1,500 patients found that supplementing with vitamin B accelerated the healing of mouth ulcers and helped prevent them from coming back. Researchers found that both ulcer healing time and ulcer treatment time were reduced by roughly two days in those taking B-complex supplements compared with control groups.

Connor says that people who don’t get adequate amounts of vitamin B through diet alone (such as strict vegans) or older adults, may need a B-complex supplement to prevent symptoms like mouth sores.

Food Sources and Vitamin B Supplements

Most people can get sufficient amounts of vitamin B through a healthy diet, says Connor. That said, some people may need to consider dietary supplements. Dosages vary, so ask your doctor about the right amount of any B vitamin or B complex for you — and to ensure that there are no interactions with medications you’re taking or conditions you have. Or, if you’re interested in upping your vitamin B intake via diet, here’s a breakdown for the best food sources for each.

Vitamin B1 (Thiamin)

Food sources: Whole grains and fortified bread, cereal, pasta, and rice; meat (especially pork) and fish, legumes such as black beans and soybeans, seeds, and nuts.

Vitamin B2 (Riboflavin)

Food sources: Eggs, organ meats (such as kidneys and liver), lean meats, and low-fat milk; some vegetables (such as mushrooms and spinach); fortified cereals, bread, and grain products.

Vitamin B3 (Niacin)

Food sources: Poultry, beef, pork, and fish; some types of nuts, legumes, and grains; enriched and fortified breads and cereals.

Vitamin B5 (Pantothenic Acid)

Food sources: Beef, poultry, seafood, and organ meats; eggs and milk; vegetables such as mushrooms (especially shiitakes), avocados, potatoes, and broccoli; whole wheat, brown rice, and oats; peanuts, sunflower seeds, and chickpeas.

Vitamin B6 (Pyridoxal Phosphate)

Food sources: Poultry, fish, and organ meats; potatoes and other starchy vegetables; fruits (including bananas, prunes, and avocados).

Vitamin B7 (Biotin)

Food sources: Meat, fish, eggs, and organ meats (such as liver); seeds and nuts; certain vegetables (such as sweet potatoes, spinach, and broccoli).

Vitamin B9 (Folate)

Food sources: Beef liver, vegetables (especially asparagus, Brussels sprouts, and dark green leafy vegetables such as spinach and mustard greens); fruits and fruit juices (especially oranges and orange juice); nuts, beans, and peas (such as peanuts, black-eyed peas, and kidney beans).

Vitamin B12 (Cobalamin)

Food sources: Fish, meat, poultry, eggs, milk, and other dairy products; clams and beef liver; some breakfast cereals, nutritional yeasts, and other food products that are fortified with vitamin B12.

The Takeaway

  • B vitamins, consumed in food or supplements, are a group of eight essential water-soluble nutrients that play crucial roles in energy metabolism, immune health, and neurological function, among other processes.
  • Studies suggest that certain B vitamins, alone or along with others, have potential benefits for both the body and mind. Research has linked B vitamins to better heart health, a more powerful immune system, a lower risk of dementia, and reduced frequency of migraine attacks.
  • Numerous foods contain B vitamins, and most people can get enough through a balanced diet that includes eggs, fish, meat, nuts, and dark leafy greens. Always discuss supplements with your healthcare provider before adding them to your routine, especially to avoid nutritional imbalances or interactions with other drugs.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. B Vitamins. MedlinePlus. September 23, 2021.
  2. What Are B Vitamins? Academy of Nutrition and Dietetics. April 3, 2025.
  3. Candelario N et al. Megaloblastic Anemia Due to Severe Vitamin B12 Deficiency. Cleveland Clinic Journal of Medicine. January 2022.
  4. Should You Take a Vitamin B12 Supplement? Harvard Health Publishing. August 15, 2022.
  5. A Close Look at Each of the B Vitamins: Benefits, Food Sources, and More. Cleveland Clinic. January 8, 2024.
  6. Karger A et al. Association Between Elevated Total Homocysteine and Heart Failure Risk in the Multi‐Ethnic Study of Atherosclerosis Cohort. Journal of the American Heart Association. February 2025.
  7. Zhang N et al. Dosage Exploration of Combined B-Vitamin Supplementation in Stroke Prevention: A Meta-Analysis and Systematic Review. American Journal of Clinical Nutrition. March 2024.
  8. The Vitatops Trial Study Group. B Vitamins in Patients With Recent Transient Ischaemic Attack or Stroke in the VITAmins TO Prevent Stroke (VITATOPS) Trial: A Randomised, Double-Blind, Parallel, Placebo-Controlled Trial. The Lancet Neurology. September 2010.
  9. Kumrungsee T et al. Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications. Frontiers in Nutrition. October 2020.
  10. Suwannasom N et al. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. International Journal of Molecular Sciences. January 2020.
  11. Why You Should Care About Free Radicals. Cleveland Clinic. July 2022.
  12. Chen Y et al. Effect of Vitamin B2 Supplementation on Migraine Prophylaxis: A Systematic Review and Meta-Analysis. Nutritional Neuroscience. September 2022.
  13. Yamanaka G et al. Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients. July 29, 2021.
  14. Udhayabanu T et al. Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases. Journal of Clinical Medicine. May 2017.
  15. Wang Z et al. B Vitamins and Prevention of Cognitive Decline and Incident Dementia: A Systematic Review and Meta-Analysis. Nutrition Reviews. March 2022.
  16. Beriberi. MedlinePlus. July 23, 2024.
  17. Thiamine Deficiency. Cleveland Clinic. November 2024.
  18. Retallick-Brown H et al. A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 With Broad-Spectrum Micronutrients for Premenstrual Syndrome. The Journal of Alternative and Complementary Medicine. February 2020.
  19. Yadav DK et al. Vitamin B12 Supplementation Influences Methylation of Genes Associated With Type 2 Diabetes and Its Intermediate Traits. Epigenomics. January 2018.
  20. Nutrition During Pregnancy. American College of Obstetricians & Gynecologists. June 2023.
  21. About Folic Acid. Centers for Disease Control and Prevention. May 2025.
  22. Folic Acid | Folate. MotherToBaby. January 2024.
  23. Folate. National Institutes of Health. November 2022.
  24. Marques C et al. Mechanistic Insights Into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products. Antioxidants. March 2024.
  25. Top 6 Benefits of Niacinamide. Cleveland Clinic. December 19, 2022.
  26. Shi J et al. Clinical Efficacy of Vitamin B in the Treatment of Mouth Ulcer: A Systematic Review and Meta-Analysis. Annals of Palliative Medicine. June 2021.
  27. B Vitamins and Folic Acid. National Health Service. August 3, 2020.
Maya Feller

Maya Feller, MS, RD, CDN

Medical Reviewer

Maya Feller, MS, RD, CDN, is the founder and lead dietitian at Maya Feller Nutrition. In her practice, her team provides medical nutrition therapy and nutrition coaching for hormone and metabolic health, cardiovascular disease, diabetes, mood disorders, developmental disabilities, disordered eating, and more.

Maya believes in providing inclusive nutrition education from an anti-bias, patient-centered, culturally humble approach to help people make informed food choices. May shares her approachable, food-based solutions with millions of people on her new YouTube channel as the host of the “Where Wellbeing Meets Flavor,” which includes cooking demos, exclusive interviews, and Q&As; in her on-demand masterclasses and courses, regular speaking engagements, writing, and social platform posts; and as a national nutrition expert on Good Morning America.

Maya is also on the advisory board for Shape and Parents; has been on the Today show and Tamron Hall; and has appeared in The New York Times, mindbodygreen, Food Network, Martha Stewart, Real Simple, Good Housekeeping, Cooking Light, Eating Well, Prevention, Glamour, Self, and other publications.

She is the author of Eating From Our Roots: 80+ Healthy Home-Cooked Favorites From Cultures Around the World.

Sarah-Garone-bio

Sarah Garone

Author
Sarah Garone is a licensed nutritionist, registered nutrition and dietetics technician, freelance health and wellness writer, and food blogger in Mesa, Arizona. She has written for The Washington Post, Healthline, Greatist, Verywell, and Eat This, Not That, among other outlets. She is a member of the Academy of Nutrition and Dietetics.