Dietitians Recommend These Weight Loss Supplements to Help You Lose Fat in 2025
Weight loss supplements vary in how directly they act on the body. Some, like green tea extract, may have a more direct effect by modestly increasing metabolism and fat oxidation. Others, like collagen, may support weight management more indirectly by promoting satiety and reducing appetite. Supplements alone are not a comprehensive approach to healthy weight loss, but they may help enhance weight loss due to other lifestyle changes, such as improved eating and exercise habits. It’s also important to note that clinical research and safety data on weight loss supplements varies, and clinical guidelines don’t generally include weight loss supplements.
To help provide clarity around weight loss supplements, we asked three registered dietitians to share the ones they recommend to their clients. We’ve included their picks below, along with advice on selecting weight loss supplements that are safe, effective, and reputable, as well as information about using these supplements safely and losing weight sustainably. Here are the best weight loss supplements of 2025.
Our Top Picks for the Best Weight Loss Supplements
- Best for women: Orgain Organic Plant-Based Protein With 50 Superfoods
- Best collagen: Vital Proteins Collagen Peptides
- Best fat burner: NOW Sports MCT Oil
- Best creatine: Thorne Creatine
- Best omega-3: Nordic Naturals Ultimate Omega
- Best for appetite control: Designs for Health PaleoFiber
- Best for metabolism: Pure Encapsulations Green Tea Extract
- Best budget option: NOW Foods Glucomannan Powder
- Best probiotic: Garden of Life Dr. Formulated Probiotics Fitbiotic
- Best meal replacement: Iconic Protein Shake
When to Consult Your Doctor
If you need help finding a weight loss plan that works for you, it’s best to discuss it with your primary care provider, a registered dietician, and potentially an obesity medicine physician or other provider with expertise in integrative medicine.
If you have any medical conditions or if you’re taking prescription medications, you should also speak to your doctor before you start using a weight loss supplement. While many weight loss supplements are safe to use, some — particularly those that contain caffeine — can have risky side effects involving blood pressure, heart rate, and heart function.
Additionally, dietary supplements are loosely regulated and don’t have to be safety tested before being sold. This means that dietary supplements may not always contain the exact ingredients in the amounts listed on the label. They may also contain undisclosed ingredients or contaminants such as allergens, heavy metals, and bacteria. For these reasons, it’s best to choose dietary supplements that are third-party tested or certified.

Best for Women
Orgain Organic Plant-Based Protein With 50 Superfoods
Pros
- Contains protein and fiber
- Superfood blend provides nutrients and antioxidants
- 160 calories per serving
- Plant-based
Cons
- May be overly sweet
- Can clump while mixing
Key Specs
- Key ingredient: Protein from peas, brown rice, mung beans, and chia seeds
- Supplement type: Powder
- Serving size: Two scoops
- Third-party tested: No
- Price per serving: $1.89
This powder provides 21 grams of protein per serving — from peas, brown rice, mung beans, and chia seeds — along with 10 grams of fiber from a “superfood” blend that contains organic grains, fruits, vegetables, sprouts, grasses, herbs, and spices. In addition to fiber, these whole food ingredients deliver several antioxidants and nutrients to support overall wellness. Each serving is only 160 calories, making it a great choice as a breakfast smoothie base or a post-workout snack.
This protein is available in Creamy Chocolate Fudge or Vanilla Bean. Based on our research, many customers love the flavor and texture of the shakes once they’re prepared, although some find the powder a little too sweet and prone to clumping. Since this is categorized as a food, it’s not third-party tested the way most high-quality dietary supplements are. However, Orgain is a reputable brand that many dietitians we’ve spoken to recommend.

Best Collagen
Vital Proteins Collagen Peptides
Pros
- Supports skin and joint health
- May help with fullness and muscle mass
- NSF Certified for Sport
- Available in several flavors
Cons
- No scoop included
- Not vegan-friendly
Key Specs
- Key ingredient: Bovine collagen peptides
- Supplement type: Powder
- Serving size: 4 tablespoons
- Third-party tested: Yes
- Price per serving: $1.83
The supplement is made from grass-fed bovine collagen and is available in Lemon, Chocolate, Salted Caramel, Vanilla, or Matcha — or unflavored. “Vital Proteins is a reputable brand known for high-quality, easily digestible collagen powders,” adds Berger. Vital Proteins products contain no genetically modified organisms (non-GMO) and are NSF Certified for Sport, meaning they’re free of substances banned in competitive sporting events by the United States Anti-Doping Agency.
During our research, we found that many customers were pleased with this supplement. The biggest complaints were that the product doesn’t include a scoop and that the packaging is hard to open and doesn’t reseal well. Also, collagen isn’t vegan-friendly because it’s sourced from cows.

Best Fat Burner
NOW Sports MCT Oil
Pros
- NSF Certified for Sport and Informed Sport certified
- May help increase fat burn
- More concentrated source of MCTs than coconut oil
Cons
- May cause digestive side effects
- Dose should be increased slowly
Key Specs
- Key ingredient: MCT oil
- Supplement type: Liquid
- Serving size: 1 tablespoon
- Third-party tested: Yes
- Price per serving: 36 cents
This MCT oil is also NSF Certified for Sport and Informed Sport certified, so it’s free of banned substances and safe for athletes to use. However, one major drawback of MCT oil is that it can cause digestive side effects, such as stomach pain and diarrhea, if you use too much. It’s best to start small, with about 1 teaspoon a day, then work your way up slowly to a full dose of 1 tablespoon.

Best Creatine
Thorne Creatine
Pros
- Third-party tested and NSF Certified for Sport
- May support muscle mass and recovery
- Improves brain energy
- Mixes easily into any beverage
Cons
- May have a bitter taste
- Pricier than other creatine supplements
Key Specs
- Key ingredient: Creatine monohydrate
- Supplement type: Powder
- Serving size: One scoop
- Third-party tested: Yes
- Price per serving: 48 cents
Thorne Creatine is a good choice because the brand has rigorous quality standards that include in-house and third-party testing for label accuracy and contaminants. This creatine is also NSF Certified for Sport, so athletes can rest assured that it’s free of banned substances.
Thorne Creatine is tasteless, so it mixes well into any beverage. However, it may have a slightly bitter taste for some people. It’s also more expensive than comparable creatine products, at about 50 cents per serving, as opposed to the more typical 30 to 40 cents.

Best Omega-3
Nordic Naturals Ultimate Omega
Pros
- Contains 1,280 milligrams of omega-3
- May help reduce chronic inflammation
- Doesn’t cause fishy burps
- Third-party tested and Friend of the Sea certified
Cons
- Not vegan-friendly
- May interfere with some medications
Key Specs
- Key ingredient: Purified deep sea fish oil
- Supplement type: Softgel
- Serving size: Two softgels
- Third-party tested: Yes
- Price per serving: 77 cents

Best for Appetite Control
Designs for Health PaleoFiber
Pros
- May help you feel fuller
- Supports digestive regularity
- In-house and third-party tested
- Contains prebiotic fibers for gut health
Cons
- Limited availability
- May cause digestive side effects
Key Specs
- Key ingredient: Acacia gum, cellulose, guar gum, cranberry seed powder, carrot fiber, inulin, orange fiber, glucomannan, apple pectin, psyllium husk, flaxseed, prune powder
- Supplement type: Powder
- Serving size: 5 grams
- Third-party tested: Yes
- Price per serving: 89 cents
A good way to use fiber for appetite reduction is to take a serving about half an hour before you eat a meal. However, if you’re not used to eating this much fiber, you should gradually increase your fiber intake to prevent unpleasant side effects like bloating, gas, and constipation.

Best for Metabolism
Pure Encapsulations Green Tea Extract
Pros
- May boost metabolic rate
- Third-party tested
- Caffeine-free
- Concentrated source of green tea compounds
Cons
- May affect liver health
- Pricey if you take multiple capsules daily
Key Specs
- Key ingredient: Green tea extract (decaffeinated)
- Supplement type: Capsule
- Serving size: One to four capsules
- Third-party tested: Yes
- Price per serving: 49 cents
Pure Encapsulations was also one of the most highly recommended brands among the dietitians we spoke to. The company uses third-party testing to ensure that its products are potent and free of contaminants, and it carefully sources ingredients to maintain quality control.

Best Budget Option
NOW Foods Glucomannan Powder
Pros
- May help you feel fuller
- Supports healthy digestion
- Roughly 12 cents per serving
- In-house quality testing
Cons
- Not third-party tested
- May cause digestive side effects
Key Specs
- Key ingredient: Glucomannan
- Supplement type: Powder
- Serving size: Half a teaspoon
- Third-party tested: No
- Price per serving: 12 cents
NOW Foods supplements aren’t third-party tested, but the brand does have an in-house testing process for contaminants and heavy metals, as well as to confirm label accuracy and product strength.
If you’re not used to consuming a lot of fiber, start slow with just one serving per day, then gradually increase your intake to a serving before each meal. Increasing your fiber intake too suddenly can cause uncomfortable digestive symptoms, such as bloating, constipation, and pain. Also, glucomannan can cause a beverage have a thick, gel-like texture as it sits — so it’s a good idea to drink it quickly after preparation.

Best Probiotic
Garden of Life Dr. Formulated Probiotics Fitbiotic
Pros
- Contains probiotic strains for weight loss
- High potency with 50 billion CFU
- Organic, non-GMO, and vegan
- Unflavored
Cons
- Not as convenient as a probiotic capsule
- May have an earthy taste in plain water
Key Specs
- Key ingredient: Lactobacillus and bifidobacterium cultures
- Supplement type: Powder
- Serving size: One packet
- Third-party tested: Yes
- Price per serving: $1.78
Dr. Formulated Probiotics Fitbiotic is also certified organic and non-GMO, vegan-friendly, and Real Alive Whole certified. This certification is given to products that are organic, non-GMO, and made with easy-to-absorb ingredients.
Dr. Formulated Probiotics Fitbiotic is a powder that should be mixed into water, so it’s not as convenient as probiotic capsules. In our research, we found that the product may have an unpleasant earthy taste, so it’s better when mixed into juice or smoothies, rather than plain water.

Best Meal Replacement
Iconic Protein Shake
Pros
- Made with grass-fed milk protein
- Contains protein and fiber
- 140 calories per serving
- Provides 40 percent of the daily value of calcium
Cons
- Not vegan-friendly
- Pricier than other weight loss supplements
Key Specs
- Key ingredient: Grass-fed milk protein isolate
- Supplement type: Liquid
- Serving size: One bottle
- Third-party tested: No
- Price per serving: $4.16
Meal replacement shakes are an easy way to potentially reduce your calorie intake to promote weight loss, while still providing your body what it needs. The best ones — like Iconic Protein Shakes — provide protein and well as fiber to promote lasting fullness, along with added vitamins, minerals, and antioxidants. At 140 calories per serving, these ready-to-drink shakes make a good on-the-go breakfast or a satisfying snack.
Because they’re made with milk protein, these shakes aren’t vegan-friendly. They’re also the most expensive supplement on this list, at roughly $4.16 per serving. For ready-to-drink meal replacement shakes, however, this is a fairly average price. It’s classified as a food, so it’s not third-party tested.
Comparison Table
How We Chose the Best Weight Loss Supplements
It can be tricky to find weight loss supplements that are high quality, safe, and effective. With minimal regulation on dietary supplements in the United States, there are some supplement companies that take advantage of the millions of Americans who want to lose weight, by either making exaggerated claims about their product or misrepresenting what’s inside it.
With this in mind, we spoke with three registered dietitians about the weight loss supplements they recommend and why:
- Bess Berger, RDN
- Lindsay Fencl, RD
- Trista Best, RD
I am also a registered dietitian, and I have personal experience with obesity and weight loss efforts. I used my own experiences, education, and expertise to help inform this article. I also reviewed several recent research studies to help provide more information about sustainable weight loss and safely using weight loss supplements.
What to Look for When Buying Weight Loss Supplements
When buying weight loss supplements, here are the most important factors to keep in mind:
- Ingredients: Weight loss supplements are a big category, with hundreds of different qualifying products, including many with multiple compounds or ingredients. To choose the formulation that’s the best fit for your needs, it may be best to start with how the supplement is intended to work to support weight loss. You can read more about the different types of weight loss supplements and which ingredients they contain in the next section of this article. Then bring your questions to your health provider or dietitian to get personalized guidance.
- Testing and certifications: Third-party testing and certifications show that a manufacturer has pursued outside verification of their product’s identity, label accuracy, strength, or safety. They are a sign that a supplement company values transparency and quality. Some supplement brands also have extensive in-house testing programs, but third-party testing and certifications are usually preferable because they are conducted by an independent service. It’s also important to make sure the testing and certifications are updated regularly.
- Price: Weight loss supplements range in price from a few cents per serving to several dollars. You don’t need weight loss supplements to lose weight successfully, so it’s best to avoid overspending on them and instead choose one that fits comfortably within your budget. Balance this cost with also potentially paying for a dietitian, weight loss support programs, and even cooking classes tailored to healthy living.
- Form: Weight loss supplements are available in several different forms, from protein powders and other powders to capsules, tablets, gummies, and liquids. You may have a strong preference for one type over the others, and it’s important to keep these preferences in mind while shopping.
What Are the Most Common Types of Weight Loss Supplements?
Weight loss supplements work in several different ways. Here are some of the most common types:
- Muscle builders: These supplements may promote muscle growth or help you preserve your existing muscle mass as you lose weight, especially when paired with resistance training, while also potentially increasing muscle metabolism. Examples include protein powders and creatine.
- Appetite reducers: These supplements may help you feel fuller on less food by filling your stomach or influencing hunger hormones and blood sugar. Some examples include fiber supplements, prebiotics, and probiotics.
- Fat burners: Fat-burning supplements may help your body burn slightly more calories and fat. Caffeine is the most well-known one (though high doses can come with risks), and MCT oil and green tea extract are popular options as well.
Are Weight Loss Supplements Safe?
There are hundreds of different ingredients found in weight loss supplements, including protein, fiber, amino acids, fruit and vegetable extracts, herbal extracts, antioxidants, probiotics, caffeine, and more. How safe a supplement is for you depends on several factors, including:
- The ingredients it contains and their amounts
- Your health status
- When you take the supplement and the duration of use
- What other supplements or medications you are taking
- The accuracy of the supplement label
Otherwise, the best way to ensure that the weight loss supplements you choose are as safe as possible is to look for third-party testing or certifications. That means the supplements have been checked by outside organizations to verify that they contain only what the label claims and are free of contaminants like heavy metals and bacteria.
It’s also important to follow the instructions on the supplement packaging and to not exceed the recommended daily dose, unless a doctor has recommended it. If you have any existing medical conditions or are taking any prescription medications, it’s essential to speak to your doctor before you start taking a weight loss supplement.
What’s the Best Way to Lose Weight?
Losing weight can be challenging, especially if you are trying to do it quickly. Ultimately, it comes down to consistently eating fewer calories than you burn. To learn how many calories you should aim for each day, try our weight loss calculator.
Here are several lifestyle strategies, across three different domains (diet, exercise, and stress management), that may help you reach your weight goals.
Diet
Exercise
Stress Management
FAQ
Extremely low-calorie diets and overexercising may help you lose weight rapidly, but these weight loss strategies aren’t safe or sustainable. To truly lose fat and keep it off, you need to eat at a modest calorie deficit, following an eating plan that you can feasibly stick to for life. A registered dietitian can help you develop a weight loss plan that works for you. If you have a body mass index in the obese range, you may also want to consult an obesity medicine physician about prescription medications or surgical options.
Why Trust Everyday Health

SaVanna Shoemaker, MS, RDN, LD
Author
SaVanna is a registered dietitian and health writer.
As a registered dietitan, SaVanna has worked with pregnant and postpartum women, infants and children, people with chronic kidney disease, and people who are critically ill. She is particularly interested in culinary and functional nutrition for weight loss and female hormone health.
She's currently a contributor for Forbes Vetted, Sports Illustrated Showcase, Mashable, and Carb Manager, and her work has also appeared in Greatist, mindbodygreen, and Bicycling Magazine, among other outlets.
SaVanna lives with her husband and three kids in Little Rock, Arkansas. She enjoys cooking, baking, gardening, and weightlifting.

Orlando de Guzman
Fact-Checker
Orlando de Guzman is a writer and editor with expertise in health and environmental news. He has a background in investigative and science journalism and has worked on documentary films about war and trauma, health, sanitation, and the changing climate around the world. His interest in health and medicine started after an early career as a medical and legal translator.
De Guzman is a longtime health and fitness enthusiast who is interested in nutrition, diet, and mental health. He participates in endurance sports and cross-trains in several traditions of martial arts from Southeast Asia. De Guzman is interested in how the progressively complex movements of martial arts training can improve cognition and mental well-being, especially for those with PTSD and for those approaching middle age and beyond.
De Guzman has a dual B.A. in communications and international studies from the University of Washington in Seattle. He is committed to factual storytelling and evidence-based reporting on critical choices that affect our planet.
- Dietary Supplements for Weight Loss. National Institutes of Health: Office of Dietary Supplements. May 18, 2022.
- Overweight and Obesity Statistics. National Institute of Diabetes and Digestive and Kidney Diseases. September 2021.
- Rogan MM et al. Dietary Energy Intake Across the Menstrual Cycle: A Narrative Review. Nutrition Reviews. November 11, 2022.
- Moccia P et al. Body Weight and Fat Mass Across the Menopausal Transition: Hormonal Modulators. Gynecological Endocrinology. February 2022.
- Moon J et al. Clinical Evidence and Mechanisms of High-Protein Diet-Induced Weight Loss. Journal of Obesity & Metabolic Syndrome. September 30, 2020.
- Akhlaghi M. The Role of Dietary Fibers in Regulating Appetite, an Overview of Mechanisms and Weight Consequences. Critical Reviews in Food Science and Nutrition. October 2022.
- Campos LD et al. Collagen Supplementation in Skin and Orthopedic Diseases: A Review of the Literature. Heliyon. March 28, 2023.
- Jadhav HB et al. Triglycerides of Medium-Chain Fatty Acids: A Concise Review. Journal of Food Science and Technology. June 22, 2022.
- Tsujino S et al. Effect of Continuous Ingestion of 2 g of Medium-Chain Triglycerides on Substrate Metabolism During Low-Intensity Physical Activity. Nutrients. January 26, 2022.
- Wu S et al. Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021. Nutrients. March 16, 2022.
- Khanna D et al. Obesity: A Chronic Low-Grade Inflammation and Its Markers. Cureus. February 2022.
- Omega-3 Fatty Acids. National Institutes of Health: Office of Dietary Supplements. December 17, 2024.
- Dempsey M et al. The Influence of Dietary and Supplemental Omega-3 Fatty Acids on the Omega-3 Index: A Scoping Review. Frontiers in Nutrition. January 2023.
- Kelly RK et al. Increased Dietary Fiber Is Associated With Weight Loss Among Full Plate Living Program Participants. Frontiers in Nutrition. April 17, 2023.
- Pražnikar ZJ et al. Effects of Four Different Dietary Fibre Supplements on Weight Loss and Lipid and Glucose Serum Profiles during Energy Restriction in Patients with Traits of Metabolic Syndrome: A Comparative, Randomized, Placebo-Controlled Study. Foods. May 24, 2023.
- Barber TM et al. The Health Benefits of Dietary Fibre. Nutrients. October 21, 2020.
- Lin Y et al. The Effect of Green Tea Supplementation on Obesity: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Phytotherapy Research. October 2020.
- Younes M et al. Scientific Opinion on the Safety of Green Tea Catechins. EFSA Journal. April 18, 2018.
- Au-Yeung F et al. The Effects of Gelled Konjac Glucomannan Fibre on Appetite and Energy Intake in Healthy Individuals: A Randomised Cross-Over Trial. The British Journal of Nutrition. January 2018.
- Álvarez-Arraño V et al. Effects of Probiotics and Synbiotics on Weight Loss in Subjects With Overweight or Obesity: A Systematic Review. Nutrients. October 17, 2021.
- Ilich JZ et al. Role of Calcium and Low-Fat Dairy Foods in Weight-Loss Outcomes Revisited: Results From the Randomized Trial of Effects on Bone and Body Composition in Overweight/Obese Postmenopausal Women. Nutrients. May 23, 2019.
- Evans J et al. Caffeine. StatPearls. May 2024.
- Freire R. Scientific Evidence of Diets for Weight Loss: Different Macronutrient Composition, Intermittent Fasting, and Popular Diets. Nutrition. January 2020.
- Casanova N et al. Metabolic Adaptations During Negative Energy Balance and Their Potential Impact on Appetite and Food Intake. The Proceedings of the Nutrition Society. August 2019.
- Adult Activity: An Overview. Centers for Disease Control and Prevention. December 20, 2023.
- Wewege MA et al. The Effect of Resistance Training in Healthy Adults on Body Fat Percentage, Fat Mass and Visceral Fat: A Systematic Review and Meta-Analysis. Sports Medicine. February 2022.
- Geiker NR et al. Does Stress Influence Sleep Patterns, Food Intake, Weight Gain, Abdominal Obesity and Weight Loss Interventions and Vice Versa? Obesity Reviews. January 2018.
- Liu S et al. Sleep Deprivation and Central Appetite Regulation. Nutrients. December 2022.
- Offer S et al. The Association Between Childhood Trauma and Overweight and Obesity in Young Adults: The Mediating Role of Food Addiction. Eating and Weight Disorders. July 30, 2022.
- Inayat F et al. The Risky Side of Weight-Loss Dietary Supplements: Disrupting Arrhythmias Causing Sudden Cardiac Arrest. BMJ Case Reports. December 19, 2018.