The 14 Best Probiotic Supplements for Men in 2025, According to RDs

We Asked 9 RDs What Probiotic Supplements They Recommend for Men — Here’s What They Said

As research into the gut’s connection to various aspects of health evolves, maintaining a healthy gut microbiome is more critical than ever. For men, gut health is important as it may support digestion, the prostate gland, and possibly sperm health. Taking probiotics — the so-called “good” bacteria — can promote a balanced gut microbiome, which is linked to improved digestion and reduced inflammation.

 Certain probiotic bacteria strains may also support prostate health, potentially lowering the risk of prostate issues, says Kathryn Durston, RDN, owner of Naturally Good Nutrition in Grand Rapids, Michigan.

While more research into the best probiotic strains for men’s health is needed, studies are examining the benefits of probiotics for the general population. Probiotic-rich foods like yogurt and kimchi are widely available, but men who don’t eat these foods may be looking for probiotic supplements to fill the gap. To help you sort through the noise, we consulted with nine nutrition experts to highlight the best probiotics for men based on lifestyle, stage of life, and health goals.

Our Top Picks for the Best Probiotics for Men

When to Consult Your Doctor

Everyday Health recommends speaking with your doctor before adding any supplement to your diet to make sure it’s safe and appropriate for your individual health needs. Consult your doctor or healthcare provider if you have a weakened immune system, are on immunosuppressant drugs, or have another critical illness. Having an immune system weakened by illness or taking immunosuppressant medications can increase the risk of infection when taking probiotics.

Best With Prebiotics

Seed DS-01 Daily Synbiotic

$53.99 at Amazon
$64.99Now 17% Off

Pros

  • Researched probiotics and prebiotics
  • Gut-friendly form of prebiotics
  • Tested for bacterial survivability
  • Third-party tested

Cons

  • Some users may experience gas
  • May cause histamine intolerance

Key Specs

  • AFUs: 53.6 billion AFU
  • Probiotic strains: 24 lactobacillus and bifidobacterium strains
  • Other ingredients: Polyphenols
  • Form: Capsule
  • Serving size: 2 capsules
  • Third-party tested: Yes

If you are seeking a high-quality, third-party-tested probiotic and your diet lacks fiber, Seed DS-01 Daily Synbiotic may be a good choice. This supplement blends 53.6 active fluorescent units (AFUs) of clinically studied probiotic strains with prebiotics, beneficial fibers that are a primary fuel source for the probiotic bacteria.

You may see that other probiotic supplements display the number of "colony-forming units," or CFUs on their labels. The number of CFUs in a probiotic supplement defines a product's probiotic potency. However, Seed DS-01 Daily Synbiotic uses AFUs, a measurement that’s said to more precisely determine the active bacteria count.


A synbiotic contains both prebiotics and probiotics that work in synergy to produce their benefits. “Seed DS-01 Daily Synbiotic is my top choice for a probiotic with prebiotics because it pairs 24 clinically studied probiotic strains with prebiotics. Prebiotics help nourish the gut lining and improve gut health by promoting the production of short-chain fatty acids (SCFA) like butyrate,” says Caitlin Beale, RDN, owner of Caitlin Beale Wellness in San Francisco.

 Studies suggest that SCFAs can positively impact the immune system, lower inflammation, and may even have protective effects on the heart and brain.

This probiotic is third-party tested, and the company conducts extensive testing of its own for allergens, pesticides, heavy metals, and more to ensure the highest safety and quality standards.

Customers who are sensitive to histamine note that this product caused symptoms of histamine intolerance like headaches and digestive issues. This may be because certain strains of probiotics, such as Lactobacillus rhamnosus, can secrete histamine in the body, which can cause a reaction in those who are histamine sensitive.

‌All Seed products are sold by subscription; you can choose deliveries every month, every three months, or every six months.

Best for Bloating

Align Probiotic Bloating Relief + Food Digestion

$28.48 at Amazon
$29.98Now 5% Off

Pros

  • Clinically studied strain for bloating
  • Digestive enzyme blend
  • B12 to break down food

Cons

  • May cause gas and bloating

Key Specs

  • CFUs1 billion
  • Probiotic strainsBifidobacterium longum 35624
  • Other ingredientsB12, digestive enzyme blend
  • FormCapsule
  • Serving size: 1 capsule
  • Third-party testedYes
If you’re looking for a probiotic supplement for bloating, Align Probiotic Bloating Relief + Food Digestion contains 1 billion CFUs of a single probiotic strain to help reduce bloating. While there’s no universally recommended CFU count, a minimum of 1 billion CFUs has shown benefits in research, and more may be recommended for certain uses, according to your doctor’s recommendations.

Gastroenterologists developed the strain present, B. longum 35624, to help relieve occasional gas, bloating, and digestive discomfort. According to an observational study, using B. longum 35624 for 30 days helped reduce digestive symptoms like abdominal pain and bloating in people with irritable bowel syndrome (IBS).

In addition to probiotics, this supplement contains 100 percent of the daily value for vitamin B12 and has digestive enzymes, which can help break down food for more efficient digestion.

Some research shows that low vitamin B12 levels are associated with lower testosterone and higher levels of infertility in men, making the B12 a helpful addition.

Best for IBS

SFI Health Ther-Biotic Pro IBS Relief

$34.15 at Amazon
$37.94Now 10% Off

Pros

  • Researched strains for gut health and IBS
  • Gentle prebiotic for sensitive stomachs
  • Third-party tested

Cons

  • May cause gas

Key Specs

  • CFUs: 20 billion
  • Probiotic strains: Lactobacillus plantarumLactobacillus acidophilusBifidobacterium lactis
  • Other ingredients: Sunfiber, polysaccharide complex
  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes
For men with irritable bowel syndrome, SFI Health Ther-Biotic Pro IBS Relief is designed to reduce IBS-related symptoms like constipation, bloating, and diarrhea. This probiotic supplement contains the prebiotic Sunfiber, a soluble fiber derived from guar gum, which is often used as a thickening agent and may be more gentle on the stomach for people with IBS.

SFI Health Ther-Biotic Pro IBS Relief contains 20 billion CFUs with three key probiotic strains as part of its blend: L. plantarum, L. acidophilus, and Bifidobacterium lactis — some of the best probiotic strains for IBS-related symptoms.

“SFI Health Ther-Biotic Pro IBS Relief is one of my top picks for IBS because it pairs well-studied probiotic strains with a gentle, gut-friendly prebiotic called partially hydrolyzed guar gum,” says Alyssa Simpson, RDN, a digestive health dietitian in Phoenix, Arizona.

This SFI supplement is a game changer for Simpson's patients who can’t tolerate high-FODMAP fibers, which can exacerbate IBS symptoms in those who are sensitive. (FODMAP is an acronym for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols.)

“I also love that it uses InTactic technology to protect the probiotics from stomach acid — super important to actually get those good bugs delivered to the large intestine where they can do their job,” says Simpson. This proprietary carbohydrate complex, also known as a polysaccharide complex, is derived from seaweed and protects the probiotic as it moves through the digestive system to facilitate optimal absorption.

SFI Health (formerly Klaire Labs) uses third-party testing to ensure the safety and potency of its products, and it’s transparent about sharing studies conducted on its ingredients in its FAQs section.

Some customers report receiving either an empty pill box or a smaller amount than ordered, so it’s important to check the package upon delivery. The company has a 30-day money-back guarantee return policy for any reason, including this one.

Best for Immune Support

Douglas Laboratories Multi-Probiotic 40 Billion

$45.60 at Amazon

Pros

  • Multiple strains to support immunity
  • Prebiotics
  • CGMP-certified

Cons

  • Prebiotic fiber may cause gas

Key Specs

  • CFUs: 40 billion
  • Probiotic strains: 16 lactobacillus and bifidobacterium strains
  • Other ingredients: Prebiotic fiber
  • Form: Capsule
  • Serving size: 2 capsules
  • Third-party tested: Yes
Douglas Laboratories Multi-Probiotic 40 Billion contains prebiotic fiber and several probiotic strains that can support your immune system. “Research shows that a balanced gut microflora plays a significant role in supporting immune function,” says Jessica DeGore, RD, CDCES, owner of Dietitian Jess Nutrition in Pittsburgh.

This high-quality supplement is a top choice because it contains 16 strains of probiotics and prebiotics, creating a synbiotic effect that helps establish a healthier gut environment, says DeGore.
One of the strains of bacteria used in this probiotic, L. plantarum, may help reduce inflammation and help promote a healthy immune system.

Another primary strain in this two-in-one product is L. acidophilus, one of the most researched probiotic strains. L. acidophilus supports gut health and immunity by reducing inflammation in the gastrointestinal tract and increasing healthy bacteria while reducing the growth of pathogenic (harmful) bacteria, says Beale.

This product also contains Nutraflora prebiotic fiber, a soluble, shorter-chain fiber that nourishes immune-supporting probiotics and may be easier to tolerate than longer-chain fibers like inulin.

Douglas Laboratories has been in business for 65 years and conducts regular in-house testing, and its products are certified for current good manufacturing processes (CGMP).

Best for Vegetarians

Future Kind Vegan Probiotic

$24.29 at Amazon
$26.99Now 10% Off

Pros

  • Vegan
  • Clinically studied strains for men’s health
  • Third-party tested
  • CGMP certified

Cons

  • Gellan gum may slow digestion
  • Poor customer service reported

Key Specs

  • CFUs: 30 billion
  • Probiotic strains: Bacillus subtilisBifidobacterium breveBifidobacterium coagulans, B. lactisBifidobacterium longumLactobacillus caseiL. plantarumL. rhamnosusLactobacillus salivarius, Lactobacillus acidophilus
  • Other ingredients: None
  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes

If you follow a vegan lifestyle, Future Kind Vegan Probiotic contains nine bifidobacterium and lactobacillus strains in a vegan formulation that supports a healthy metabolism, digestion, immunity, and more.

“This once-a-day probiotic contains 30 billion CFUs from 10 strains, says Lauren Panoff, RD, cofounder of The Food Trends in Denver. “The multiple evidence-backed strains include L. rhamnosus, which supports gut health and helps with IBS, and Bacillus subtilis, a soil-based probiotic that can also support immune health.” It’s also free from major allergens.

This supplement undergoes regular independent testing to ensure that quality and safety standards are maintained. A certificate of analysis is available for transparency and added trustworthiness.

Some customers had difficulty reaching the company when trying to return products and report that shipping was very slow.

Most Budget-Friendly

Now Foods Probiotic-10

$21.74 at Walmart
$49.99Now 57% Off

Pros

  • Most affordable on our list
  • Third-party tested
  • CGMP certified

Cons

  • May cause digestive distress
  • Top may not seal tightly

Key Specs

  • CFUs: 25 billion
  • Probiotic strains: Lactobacillus, bifidobacterium, Streptococcus thermophilus
  • Other ingredients: None
  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes

Now Foods Probiotic-10 is our top pick for the most budget-friendly men’s probiotic, as it contains 10 research-backed strains for as little as $8 for a month’s supply. “This budget-friendly probiotic is under $25 a bottle, making it easy on the wallet,” says Lauren Manaker, RDN, owner of Nutrition Now Counseling in Charleston, South Carolina. “It’s made with a blend of 10 strains of bacteria, provided in impressive quantities, with each supplement delivering a potency of 25 billion CFUs through the best-by date.”

It comes in an easy-to-swallow capsule and contains several clinically studied lactobacillus, bifidobacterium, and streptococcus strains, which may reduce symptoms of IBS-related diarrhea compared with a placebo.

All Now Foods probiotics are CGMP certified, ensuring that quality control measures are followed. In addition, the products are certified by Underwriters Laboratories, a reputable organization that requires strict safety, quality, and security standards.

Another factor that sets Now Foods apart is its dedication to charity and reducing malnutrition. It’s one of two founding members of Vitamin Angels, a nonprofit organization that donates essential vitamins to malnourished children worldwide, making the products more accessible to those who need them most.

Some customers report that the top of the container doesn’t always seal tightly, which could reduce its shelf life. A few users complain of worsened bloat and gas after taking this supplement. It’s important to monitor for symptoms when taking any probiotic supplement.

Best for Fertility Support

Needed Sperm Support+

$59.84 at Amazon
$62.99Now 5% Off

Pros

  • Clinically studied strains for fertility
  • Sperm health and vitality blend
  • Added prebiotics
  • Third-party tested

Cons

  • Fewer CFU count than other products on our list

Key Specs

  • CFUs14 billion
  • Probiotic strainsL. acidophilus NCFM, B. lactis BI-07, B. lactis BI-04, Bacillus clausii, Bacillus subtilis DE111
  • Other ingredientsPomegranate fruit extract, shilajit extract, NAC, alpha-lipoic acid, ashwagandha root and leaf extract, tongkat ali extract, Tribulus terrestris fruit extract, lycopene, green tea leaf extract, blueberry fruit extract
  • FormCapsule
  • Serving size: 2 capsules
  • Third-party tested: Yes
Emerging research suggests that probiotics may help increase sperm count in men with infertility.

Needed Sperm Support+ contains probiotics, prebiotics, antioxidants, and other ingredients that may protect the integrity and health of sperm. It contains 14 billion CFUs and five probiotic strains, including bifidobacterium and lactobacillus strains, which have been shown to have positive effects on sperm count and overall health.

“Needed Sperm Support+ combines probiotics, antioxidants, and N-acetyl cysteine (NAC) to support sperm health. Probiotics may positively affect sperm quality, while antioxidants like NAC help combat oxidative stress, a significant factor in sperm damage. Some research suggests that supplementing with NAC may help increase sperm count, motility, and other measurements of sperm health,” says Beale.

As part of its sperm health and vitality blend, this product also contains shilajit extract, alpha-lipoic acid, ashwagandha, and Tribulus terrestris fruit extract. Shilajit extract is a plant-based substance seen to increase sperm count and motility in a relatively small study from 2010.

Alpha-lipoic acid is a potent antioxidant that can protect sperm from DNA damage.

Ashwagandha is an herbal extract that may help the body better respond to stress and anxiety; small studies have shown that ashwagandha may improve sperm motility and sperm count.

Tribulus terrestris fruit extract may improve sperm concentration and motility.

Needed Sperm Support+ also contains tongkat ali (Eurycoma longifolia), another herbal extract that may help increase testosterone. Research has linked tongkat ali and higher testosterone levels, which may positively impact low libido, erectile dysfunction, and in some cases, infertility.

In addition, the prebiotic antioxidant blend contains decaffeinated green tea, blueberry extract, and pomegranate leaf extract, which can further protect sperm from damage, supporting overall fertility.

Best for Men Over 50

Garden of Life Raw Probiotics

$36.48 at Amazon
$52.45Now 30% Off

Pros

  • Variety of probiotics and nutrients
  • Clinically studied strains for digestive, colon, immune health
  • Whole-food based
  • Third-party tested

Cons

  • May not be suitable for people with a lactose intolerance
  • Packaging can arrive warm

Key Specs

  • CFUs: 85 billion
  • Probiotic strains: 32, including lactobacillus, bifidobacterium, Brettanomyces, and saccharomyces strains
  • Other ingredients: Digestive enzymes, fruit and vegetable blend, yogurt concentrate, vitamins, minerals
  • Form: Capsule
  • Serving size: 3 capsules
  • Third-party tested: Yes

For men over 50, Garden of Life Raw Probiotics is a smart choice. In addition to a variety of probiotic strains, it contains several vitamins and minerals that can support nutritional health for men over 50.

All Garden of Life products are derived from whole foods and are third-party tested for quality and safety. This probiotic contains 85 billion CFUs from 32 probiotic strains, including lactobacillus species, considered by researchers to be one of the most important present in the gastrointestinal tract.

‌Garden of Life Raw Probiotics guarantees the CFU count through the best-use date, providing peace of mind for its continued potency.
This supplement also provides essential vitamins and minerals for men’s health, including vitamins C, D, and B12, as well as selenium. Men over 50 may be at a higher risk of vitamin D and vitamin B12 deficiency due to reduced sun exposure and decreased absorption, which can negatively impact bone health, mental health, and energy levels.

"As we get older, our gut microbiome changes. What I love about this probiotic is that it contains two strains, bifidobacteria and lactobacillus, that can help improve stool frequency and abdominal pain, according to research.

The digestive enzyme blend can help with digestion to reduce bloating and indigestion,” says Christa Brown, RDN, of Woodbridge, New Jersey. While the digestive enzyme blend in this product is formulated for people who have trouble processing dairy, Brown says that it still may not be tolerable for people with severe lactose intolerance or dairy allergies.

If you have a vitamin deficiency and aren’t getting enough of your nutrients through food, taking this probiotic and vitamin supplement may help boost your nutrient levels and support your gut health at the same time. However, it’s likely not necessary if your vitamin levels are sufficient or you’re already taking a multivitamin.

A few customers note that the product arrived very warm and improperly insulated. If the temperature is warm, it may impact the viability of the probiotic strains present and potentially render them less effective.

If this happens to you, contact the manufacturer to request a replacement.

Best for Prostate Health

Hyperbiotics Pro-Men Probiotic

$45.59 at Amazon
$47.99Now 5% Off

Pros

  • Six targeted probiotics and curcumin for prostate health
  • Contains prebiotics
  • Time-release technology for optimal absorption
  • Easy-to-swallow tablet

Cons

  • Fewest CFUs than all the products on our list

Key Specs

  • CFUs5 billion
  • Probiotic strainsL. acidophilus, L. casei, Lactobacillus fermentum, L. plantarum 6595, Lactobacillus reuteri, B. longum
  • Other ingredients: Curcumin, prebiotics
  • FormTablet
  • Serving size1 tablet
  • Third-party testedYes
Taking probiotics may help reduce inflammation, which may include inflammation of the prostate, known as prostatitis.

Hyperbiotics Pro-Men Probiotic can help reduce the bacterial load in urine, which can support men’s urinary and prostate health. In a study on men with recurrent urinary tract infections, supplementing with Hyperbiotics Pro-Men Probiotic daily for 12 weeks reduced E. coli and E. faecalis levels, two bacteria that can cause urinary infections.

 Hyperbiotics Pro-Men Probiotic contains 5 billion CFUs, including L. plantarum, L. acidophilus, and B. longum, a few of the most dominant strains in the gastrointestinal tract.
“While it’s primarily marketed to improve digestion, Hyperbiotics Pro-Men Probiotic may be beneficial for prostate health as it contains a few strains that have been found to support the prostate,” says Ana Reisdorf, RD, founder of GLP-1 Hub in Nashville, Tennessee. “In particular, B. longum may help reduce oxidative stress and inflammation of the prostate.”

 L. rhamnosus, another strain in this product, is known for its anti-inflammatory properties, which may help reduce prostate inflammation.

Additionally, Hyperbiotics Pro-Men Probiotic contains curcumin, an anti-inflammatory compound and the active ingredient in turmeric, which has been linked to a reduction in inflammatory disorders like prostatitis.

 It also contains the prebiotic fructo-oligosaccharides. These fibers were seen in small studies to have potential brain-supporting benefits in men.

Every ingredient used in Hyperbiotics products is third-party tested, and the company guarantees that the Pro-Men Probiotic contains at least 1.5 billion viable CFUs at the date of expiration. This probiotic also utilizes a time-release delivery system, which may help the live probiotics survive in the digestive tract.

Best for Weight Loss

Jarrow Formulas Jarro-Dophilus EPS

$32.29 at Amazon
$49.99Now 35% Off

Pros

  • Clinically studied strains for weight loss
  • Third-party tested
  • Coating to protect from stomach acid
  • Vegetarian

Cons

  • No prebiotics
  • Damages easily
  • Trace amounts of dairy and soy

Key Specs

  • CFUs10 billion
  • Probiotic strains: 8 bifidobacterium, lactobacillus, and pediococcus strains
  • Other ingredients: None
  • Form: Capsule
  • Serving size: 2 capsules
  • Third-party tested: Yes
Jarro-Dophilus EPS by Jarrow Formulas is our top pick for a men’s weight loss probiotic supplement for its eight clinically studied strains, including a specific strain associated with weight loss. It also contains prebiotic fiber, which may help promote appetite control and weight loss.

“Overall, improving gut health can support a healthy weight. A healthy gut has been associated with a better metabolism, reduced inflammation, better insulin sensitivity, and the production of SCFAs that can help influence appetite hormones in a positive way,” says Reisdorf.

L. plantarum, a strain present in this product, is associated with weight loss, says Reisdorf.

She notes that the enteric coating helps protect the bacteria from stomach acid. In addition to the eight probiotic strains, this product includes potato starch, which acts as a prebiotic.

 It also contains several bifidobacterium strains, such as B. longum and B. breve, which may help reduce erectile dysfunction.

This supplement is third-party tested for safety and quality, and is made in a facility certified by the National Sanitation Foundation (NSF), one of the most reputable third-party testing sites. However, it does contain trace amounts of dairy and soy, so those with milk or soy allergies should avoid it.

Some users report that the blister packs are easily damaged. If this happens to you, contact the seller.

Renew Life Men's Care Probiotic

Best High Potency

Renew Life Ultimate Flora Men’s Care Probiotic

Pros

  • Highest CFU count on our list
  • 12 diverse strains for men’s health
  • Third-party tested

Cons

  • High dose may lead to gas, bloating
  • Strong citrusy scent

Key Specs

  • CFUs: 90 billion
  • Probiotic strains: 12 bifidobacterium and lactobacillus strains, including L. rhamnosus GG
  • Other ingredients: None
  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes

Renew Life Ultimate Flora Men’s Care Probiotic contains 90 billion CFUs, with 12 diverse strains for men seeking digestive, colon, immune, and respiratory health support. “Renew Life Men's Care Probiotic Capsules are a good choice for men due to the diverse blend of 12 probiotic strains, including the extensively studied L. rhamnosus GG, which promotes gut health, boosts the immune system, and maintains a healthy gut microbiome,” says Simpson.

This probiotic also contains Lactobacillus paracasei, a strain that one study concluded could improve the quality and quantity of sperm to support male fertility. While this study was promising, researchers note that more research is needed to confirm this benefit.

 The delayed-release capsules ensure that the probiotics survive stomach acid, reaching the colon intact for maximum effectiveness.

These supplements are free of dairy, soy, and gluten, and are third-party verified for probiotic potency and quality. Keep in mind that starting at a high dose like this may lead to gas and bloating, which typically resolves in a few weeks. A few customers also note that the pills have a strong citrus or flowery smell that is a bit overpowering.

Zenbiome Dual probiotics supplements

Best for Mental Health and Mood

Zenbiome Dual

Pros

  • Clinically studied strains for mental health
  • Dual-action for digestive and mental health support
  • Third-party tested
  • Product transparency on the website

Cons

  • Practitioner account required to purchase from the manufacturer
  • Proprietary blend

Key Specs

  • CFUs: 10 billion
  • Probiotic strains: Proprietary blend, bifidobacterium species
  • Other ingredients: None
  • Form: Capsule
  • Serving size: 2 capsules
  • Third-party tested: Yes
Emerging research is demonstrating a link between gut health and mental health, known as the gut-brain axis, leading a push for more research into the role of probiotics for mood and mental health.

Zenbiome Dual is a solid choice to support men’s mental health alongside a healthy lifestyle and stress management regimen. Its dual-action probiotic promotes digestive health and mood at the same time. It contains 10 billion CFUs, including from two bifidobacterium strains.
“This supplement contains a probiotic blend of two bifidobacterium strains that research suggests can support mental health. Zenbiome Dual supports digestion and mood with B. longum strains,” says Amy Archer, RDN, owner of WellnessRD in Campbell, California. These strains may help connect the gut-brain axis, affecting mood regulation and daily social stress.

“When consumed in adequate amounts, these probiotics improve gut diversity and may produce a mental health benefit. It provides these benefits by targeting the gut-brain axis, the nerve connection between the brain and gut,” says Archer. While we know there’s a connection between the gut and brain, more robust research is needed to confirm the connection between probiotics and mental health. We particularly appreciate the company’s transparency in sharing specific research studies on ingredients on the product pages.

To purchase directly from the website, you need a practitioner code, which you can get from a doctor, dietitian, or other qualified healthcare professional. You don’t need to this if you purchase on third-party websites such as Pure Formulas. However, it’s always best to speak to a healthcare professional prior to starting probiotics or any other supplement, regardless of where you make your purchase.

AG1 Probiotic Supplement

Best With a Multivitamin

AG1

Pros

  • All-in-one probiotic plus multivitamin
  • Contains prebiotics
  • Added adaptogens and antioxidants
  • Third-party tested

Cons

  • Lacking in some vitamins and minerals
  • Priciest on our list

Key Specs

  • CFUs: 32 billion
  • Probiotic strains: L. acidophilus, Bifidobacterium bifidum
  • Other ingredients: Vitamins, minerals, adaptogens, antioxidants, mushroom powder, enzymes
  • Form: Powder
  • Serving size: 1 scoop
  • Third-party testing: Yes

If you’re looking for an all-in-one probiotic plus a multivitamin, you may want to consider Athletic Greens, also known as AG1. This product combines a greens powder, multivitamin, probiotic, and prebiotic into a single daily scoop of powder. Greens powders are a dietary supplement to help people reach their daily intake of vitamins and minerals. However, not all greens powders contain probiotics.

The two probiotic strains used in this powder are L. acidophilus and B. bifidum, two well-studied strains for their benefits on immunity, inflammation, and gut health.

AG1 also contains ingredient complexes with antioxidants, including mushroom extracts, and adaptogens like ashwagandha, which may help the body better respond to physical and emotional stress.

While many of the vitamins in AG1 are in doses well above the recommended daily value, some minerals like calcium and magnesium are in much lower quantities than other multivitamins, and it does not contain any iron.

 It also doesn’t contain vitamin D, a vitamin that nearly one-third of Americans are deficient in and one that’s essential for men’s health.

` For this reason, you may need to take a separate vitamin D, iron, or mineral supplement, depending on your doctor’s recommendation.

AG1 is committed to the testing and safety of its ingredients, as evidenced by the NSF Certified for Sport designation. This certification is provided by one of the most reputable third-party testing agencies for ingredient purity, ensuring that no heavy metals, harmful pesticides, or banned athletic substances are present.

Best Subscription

Ritual Synbiotic+

$51.29 at Amazon
$59.74Now 14% Off

Pros

  • Convenient subscription service
  • Contains pre-, pro-, and postbiotics
  • Transparency in ingredient sourcing
  • Third-party tested

Cons

  • Minty taste may not appeal to all
  • May cause gas and bloating

Key Specs

  • CFUs: 11 billion
  • Probiotic strains: L. rhamnosus, Bifidobacterium animalis ssp. lactis (BB-12)
  • Other ingredients: Prebiotics, postbiotics
  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party testing: Yes

Signing up for a subscription service is a convenient way to build a consistent health routine to get the most benefits out of your supplements. Ritual Synbiotic+ is a three-in-one synbiotic, with a combination of probiotics, prebiotics, and postbiotics to support gut health.

Postbiotics are by-products from food digestion that may provide benefits of their own, such as supporting immunity and gut health.

 “The Synbiotic+ supplement by Ritual is one of my favorite prebiotic and probiotic options, combining clinically studied prebiotics, probiotics, and postbiotics,” says Beale. “It contains two well-researched probiotic strains, L. rhamnosus and B. animalis ssp. lactis, with 11 billion CFUs, and supports gut health, regularity, and immune function.”
L. rhamnosus is one of the first patented probiotic strains and has been studied for its effectiveness for over 30 years, including its role in digestive health and immunity.

Beale notes that this product includes a patented prebiotic blend called PreforPro, which may help decrease inflammation more than taking probiotics alone.

Ritual products are third-party tested, and the company has a scientific advisory board of medical doctors, registered dietitians, and scientists who conduct ongoing research to ensure the safety, quality, and effectiveness of its products. Ritual values transparency, too; you can find where the ingredients for its products come from on its Traceable Ingredients webpage.

Comparison Table

Best For
CFU/AFU
Key Strains
Third-party tested
Probiotics with Prebiotics
53.6 billion AFUs
24 lactobacillus and bifidobacterium strains
Yes
IBS
20 billion CFUs
L. plantarum, L. acidophilus, Bifidobacterium lactis
Yes
Immune Support
40 billion CFUs
16 lactobacillus and bifidobacterium strains
Yes
Vegetarians
30 billion CFUs
Bacillus subtilis, B. breve, B. coagulans, B. lactis, B. longum, L. casei, L. plantarum, L. rhamnosus, L. salivarius, L. acidophilus
Yes
Budget
25 billion CFUs
Lactobacillus, bifidobacterium, Streptococcus thermophilus
Yes
Fertility Support
14 billion CFUs
L. acidophilus NCFM, B. lactis BI-07, B. lactis BI-04, Bacillus clausii, Bacillus subtilis DE111
Yes
Men Over 50
85 billion CFUs
32, including lactobacillus, bifidobacterium, Brettanomyces, and saccharomyces strains
Yes
Prostate Health
5 billion CFUs
L. acidophilus, L. casei, L. fermentum, L. plantarum 6595, L. reuteri, B. longum
Yes
Weight Loss
10 billion CFUs
8 bifidobacterium, lactobacillus, and pediococcus strains
Yes
High Potency
90 billion CFUs
12 bifidobacterium and lactobacillus strains, including L. rhamnosus GG
Yes
Mental Health and Mood
10 billion CFUs
Bifidobacterium species
Yes
Probiotics With a Multivitamin
32 billion CFUs
L. acidophilus, B. bifidum
Yes
Subscription
11 billion CFUs
L. rhamnosus, B. animalis ssp. lactis (BB-12)
Yes

How We Chose the Best Probiotic Supplements

We consulted with nine qualified nutrition experts, all of whom are registered dietitians, to select the best probiotics for men’s health. These experts are well versed in supplements and do not have any financial conflicts of interest. I’m also a registered dietitian, with over 18 years of experience in health and wellness.

Here are the specific characteristics we used to find the best probiotics for our list:

  • Research-studied strains for men’s health
  • Number of CFUs
  • Addition of prebiotics and other ingredients
  • Third-party testing or certification
  • Brand trustworthiness
  • Positive customer reviews

Here are the nine nutrition experts we consulted for additional expertise and insights:

  • Kathryn Durston, RDN
  • Caitlin Beale, RDN
  • Alyssa Simpson RDN
  • Jessica DeGore, RD, CDCES
  • Lauren Panoff, RD
  • Lauren Manaker, RDN
  • Christa Brown, RDN
  • Ana Reisdorf, RD
  • Amy Archer, RDN

What to Look for When Buying a Probiotic Supplement

When shopping for the best probiotics for men, here are some key features to look for to make the most out of them.

Intended use: “When choosing a probiotic supplement for men, look for one that contains well-researched strains tailored to your specific health goals,” says Durston. Different strains offer distinct benefits. For example, lactobacillus species have been linked to improvements in male fertility by supporting sperm health and reducing oxidative stress.

Well-researched strains: Look for probiotic strains that have been well researched for safety and effectiveness, such as lactobacillus and bifidobacterium strains. “I like seeing the more heavily researched strains, including B. bifidum, L. rhamnosus GG, and L. acidophilus,” says Brown.

CFUs: CFU totals indicate the quantity of bacteria per dose. While there is no universally recommended CFU count, a minimum of 1 billion CFUs is the potency seen to show benefits in research studies, and more may be recommended for certain uses, according to your doctor’s recommendations.

Third-party testing: Our experts all agree that customers should seek out a probiotic that has undergone third-party testing or has been independently tested to ensure its quality, potency, and safety. A few of the most reputable third-party testing agencies are United States Pharmacopeia (USP) and the NSF. Other certifications that attest to quality are CGMP or Clean Label.

Potential allergens: Check for additional ingredients like lactose, gluten, or soy if you have any sensitivities, as these can affect tolerability.

FAQ

Who should take probiotic supplements?
Anyone who wants to support their overall digestion, immunity, and well-being may benefit from probiotic supplements. However, people with weakened immune systems may be at a heightened risk of infection from the bacteria in the supplements and should speak to their doctor before taking them.
Probiotics can support men’s health by promoting a balanced gut microbiome, which is linked to improved digestion and reduced inflammation. Certain strains may also support prostate health as well as male fertility.
Several foods and beverages are high in probiotics, including Greek yogurt, kefir, kimchi, cottage cheese, miso, and kombucha, a fermented tea.
Some people may experience gas, bloating, diarrhea, or stomach upset when starting probiotic supplements. For many people, these side effects resolve within a few weeks, once the body adjusts to the probiotic. Start with a smaller dose and slowly increase it to allow your body to become acclimated. If side effects last longer than a few weeks, stop taking it and consult with your medical provider for guidance.

Why Trust Everyday Health

We independently investigate and recommend products and services we believe will enrich the lives of our readers and meet their specific needs. You can trust our reviews because we do the legwork for you. Read more about why you can trust us.

Melissa Mitri, MS, RD

Author

Melissa Mitri is a registered dietitian-nutritionist, weight loss specialist, and expert health writer with over 18 years of experience in the health and wellness industry. She owns Melissa Mitri Nutrition, a virtual private practice helping women achieve sustainable weight loss.

Melissa is a freelance writer and editor for dietitians and wellness brands. She helps translate complicated scientific research into easy-to-understand terms for the public. Melissa has written for various publications and websites, such as HealthCanal, WellnessVerge, Nature Made, Garden of Life, the Avocado Board, and more.

Melissa believes everyone has the power to improve their health, one small habit at a time. Her approach to healthy eating focuses on what to eat more of for better health versus what to restrict or eliminate in the diet.

Melissa lives in Connecticut with her husband and two boys, where she enjoys training for half-marathons, reading, and traveling with her family.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
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