9 Best RD-Approved Methylated Multivitamins for Women in 2025
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Here Are the 9 Best Methylated Multivitamins for Women, Chosen by Dietitians

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Published on May 9, 2025
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Over half of people in the United States have a mutation on the methylenetetrahydrofolate reductase (MTHFR) gene — many of them women. MTHFR mutations can impair your body's ability to methylate, or process, B vitamins like folate and vitamin B12. Methylation is a key step so that your body can utilize these vitamins. The only way to know if you have an MTHFR gene mutation is through a DNA test.

Taking methylated vitamins may help people with this gene variant absorb nutrients. "Methylated multivitamins contain nutrients in their active, bioavailable forms, such as methylfolate instead of folic acid and methylcobalamin instead of regular B12," says Trista Best, MPH, RD, of Balance One in Dalton, Georgia. Although there isn't a lot of scientific evidence that methylated multivitamins are necessarily better than other multivitamins, our research found that many people who know or suspect that they have MTHFR variants prefer methylated multivitamins. Since women who have MTHFR variants may need methylated multivitamins for optimal nutrient absorption, it may be beneficial to take methylated vitamins whether you have the variant or not.

To help you find the best methylated multivitamins for women, I consulted with three registered dietitians to come up with a list of products based on quality ingredients, effectiveness, and third-party testing.

Our Top Picks for the Best Methylated Multivitamins for Women

When to Consult Your Doctor

Everyday Health recommends that you consult a healthcare provider before adding any new supplement to your routine. Many multivitamins — methylated or not — contain ingredients that may interfere with certain medications. For example, vitamin K may affect blood thinning medications, and minerals like magnesium and calcium can bind with medications and prevent them from being absorbed if taken at the same time. If you’re taking any prescription medications, it's best to consult your doctor before starting a multivitamin supplement.

Some people choose methylated multivitamins to help them have more energy and feel less fatigued, dizzy, or mentally cloudy. However, there are several potential causes for these symptoms. If you have any of these symptoms, it's best to visit your doctor for a full workup to determine the exact cause.

Fullwell women's multivitamin

Best for Hormonal Health

FullWell Women's Multivitamin

Buy Now $49.95

Pros

  • Contains hormone-supporting inositol and grape seed
  • Methylated,  easy-to-absorb nutrients
  • Dietitian designed and third-party tested

Cons

  • Limited ordering options

Key Specs

  • Form: Capsule
  • Serving size: 3 capsules
  • Third-party tested: Yes
  • Dietary considerations: Free from nine major allergens (gluten, wheat, dairy, peanuts, tree nuts, shellfish, eggs, sesame, and soy)

FullWell Women's Multivitamin was designed by a registered dietitian and contains methylated folate and vitamin B12, along with highly bioavailable (easy to absorb) forms of 22 other nutrients. It's third-party tested and includes ingredients like inositol and grape seed that support hormonal health for menstruating and perimenopausal women. For these reasons, it's our overall pick for a methylated vitamin for hormonal health.

In several studies, inositol (a form of sugar) has been shown to promote menstrual cycle regularity, hormone balance, and blood sugar control in women with polycystic ovarian syndrome (PCOS).

 Grape seed contains antioxidants that may support female fertility and menstrual regularity in women with and without PCOS.

FullWell products are third-party tested for the presence of contaminants, common allergens, and heavy metals. A dose is three capsules, which might be an obstacle for people who don’t like swallowing pills.

Best Once Daily

Pure Encapsulations O.N.E. Multivitamin

$45.20 at Amazon
Buy on Amazon $45.20

Pros

  • Dose is a single capsule
  • Easy-to-absorb nutrients
  • Contains added antioxidants
  • Third-party tested

Cons

  • May cause nausea on an empty stomach
  • Has a strong smell

Key Specs

  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes
  • Dietary considerations: Free from six common allergens (wheat, soy, dairy, eggs, tree nuts, and peanuts)

For a complete methylated multivitamin in just one daily capsule, Pure Encapsulations O.N.E. is an excellent choice. "It offers once-daily support, with fully methylated B vitamins and antioxidants," says Bess Berger, RDN, founder of Nutrition by Bess in Teaneck, New Jersey.

In addition to essential vitamins and minerals in bioavailable forms, O.N.E. Multivitamin contains the antioxidants lutein, zeaxanthin, alpha lipoic acid, and lycopene to support eye health, liver health and detoxification, and nervous system function.

 It also includes inositol to support hormone balance, particularly in women with PCOS.

Pure Encapsulations products are third-party tested to ensure that they're safe and free of contaminants. However, since this product contains vitamin D derived from sheep's wool, it is not vegan. Additionally, our research uncovered that some customers experience nausea after taking this vitamin — especially on an empty stomach, according to the package — so it should be taken with a meal. Some customers also say it has a very strong, unpleasant smell.

Best Prenatal

Perelel Prenatal Packs

$55.34 at Amazon
$58.25Now 5% Off
Buy on Amazon $55.34

Pros

  • Contains 700 mcg of folate
  • Methylated B vitamins, omega-3, iron
  • Third-party tested
  • Convenient daily packs
  • HSA eligible, FSA eligible

Cons

  • A serving is four or five capsules per day
  • Priciest on our list

Key Specs

  • Form: Capsule and softgel
  • Serving size: One pack
  • Third-party tested: Yes
  • Dietary considerations: Free from six common allergens (wheat, soy, dairy, eggs, tree nuts, and peanuts)
Perelel makes targeted daily vitamin packs for each trimester of pregnancy, as well as preconception, postpartum, and perimenopause. All of the prenatal options include a methylated multivitamin as the foundational component, along with iron and omega-3 to support overall wellness. The multivitamin provides 700 micrograms (mcg) of folate from 5-methyltetrahydrofolate (5-MTHF), which can help reduce the risk of neural tube defects in a developing fetus.

Each pack also provides other supplements to support optimal health and symptom management specific to your life stage and needs. For example, the First Trimester Prenatal Pack has an anti-nausea supplement, featuring ginger root, which may help combat morning sickness.

 The Peri Support Pack for perimenopause contains 3,3'-diindolylmethane, an extract from cruciferous veggies like broccoli and kale, which may support estrogen metabolism and body composition.

A serving is four or five capsules. Perelel Prenatal Packs are third-party tested for purity, heavy metals, and microbial contamination. Because all of the prenatal packs include omega-3 fish oil, the products are not vegan. The packs are convenient and travel-friendly, with added supplements for your life stage.

Best Liquid

Trace Liquid Multi Vitamin-Mineral

$37.79 at Amazon
$41.99Now 10% Off
Buy on Amazon $37.79

Pros

  • Easy-to-take liquid
  • Third-party tested
  • Contains added citrus bioflavonoids

Cons

  • Must be refrigerated
  • Flavors may not appeal to all; sweetened with stevia

Key Specs

  • Form: Liquid
  • Serving size: 2 tablespoons
  • Third-party tested: Yes
  • Dietary considerations: Gluten-free

If you don’t like pills or have trouble swallowing them, a liquid methylated multivitamin like this one from Trace may be your best choice. It contains methylated folate and vitamin B12, along with over 20 other nutrients. It's available in tropical mixed berry and orange mango flavors, and sweetened with stevia, a plant-based extract.

This liquid multivitamin also has 25 milligrams (mg) of citrus bioflavonoids, which are antioxidant compounds found in citrus fruits that may help reduce inflammation and support metabolic and heart health.

 Trace products are third-party tested to ensure that the contents match what's listed on the label.

Our research revealed mixed reviews about the taste — some people love it, while others find it too sweet. Additionally, Trace uses vitamin D3 from wool, so this liquid multivitamin is not vegan.

Best for Women Over 50

Rainbow Light Women’s One Multivitamin

$11.69 at Amazon
$14.44Now 19% Off
Buy on Amazon $11.69

Pros

  • Pomegranate and grape extract for menopause support
  • Contains ashwagandha for stress relief
  • Non-GMO verified
  • Added probiotics

Cons

  • Contains folic acid, not methylated folate
  • Not third-party tested

Key Specs

  • Form: Tablet
  • Serving size: 1 tablet
  • Third-party tested: No
  • Dietary considerations: Gluten-free, vegetarian
For women over 50, a multivitamin with ingredients that help manage menopause symptoms may be a good choice. This one from Rainbow Light contains a botanical blend that includes ashwagandha, an herb that may help with anxiety and stress relief in perimenopausal women,

 and pomegranate extract, which may help with hot flashes and weight gain due to menopause.

 It also includes a probiotic blend and a superfoods blend made from beets, broccoli, kale, blueberries, carrots, cranberries, and other real foods.

Although the vitamin B12 is in methylated form, the folate in this multivitamin is not methylated, so this supplement may not be a good fit for people who have the MTHFR gene mutation. It's also not third-party tested, but Rainbow Light follows current good manufacturing practice (CGMP) guidelines to ensure that its products are safe and effective. During our research, we noted that many users say the tablet is large and difficult to swallow. Additionally, while it's vegetarian-friendly, it's not vegan because of the type of vitamin D it contains.

Best With Iron

Metagenics PhytoMulti With Iron

$39.15 at Amazon
$43.50Now 10% Off
Buy on Amazon $39.15

Pros

  • Contains 100 percent of the daily value for iron
  • Added antioxidants
  • More than 20 vitamins and minerals
  • Plant-based ingredients

Cons

  • Iron may cause digestive upset

Key Specs

  • Form: Tablet
  • Serving size: 2 tablets
  • Third-party tested: No
  • Dietary considerations: Gluten-free, non-GMO
Iron deficiency is common in women, especially those who menstruate.

 Choosing a supplement with iron, like Metagenics PhytoMulti With Iron, can help you meet your iron goals to prevent or reverse iron deficiency anemia and its accompanying symptoms like dizziness and fatigue.

 Two tablets of PhytoMulti With Iron contain 18 mg of iron, which is 100 percent of the daily value.
This multivitamin has methylated vitamin B12 and folate, along with about 20 other vitamins and minerals. For overall health, it’s also formulated with a phytonutrient blend that includes antioxidant-rich plant extracts, along with inositol and antioxidants that support eye, brain, and heart health.

Metagenics vitamins aren't third-party tested, but they meet CGMP standards. This product isn't vegan because it contains wool-based vitamin D. Also, iron supplementation may cause constipation and can change the color of your stool. To help reduce the side effects associated with iron, drink plenty of fluids each day and take the supplement with a meal.

Best Vegan

Power by Naturals Methyl Multi One

$35.95 at Amazon
$39.95Now 10% Off
Buy on Amazon $35.95

Pros

  • Certified vegan
  • Third-party tested
  • Contains nutrients, antioxidants, CoQ10
  • Gluten- and lactose-free, non-GMO

Cons

  • Some find the smell unpleasant

Key Specs

  • Form: Capsule
  • Serving size: 1 capsule
  • Third-party tested: Yes
  • Dietary considerations: Vegan, gluten-free, soy-free, lactose-free, non-GMO

Power by Naturals is a certified vegan multivitamin with methylated folate and vitamin B12. Many multivitamins — even some that are marketed as vegetarian-friendly — contain animal-sourced ingredients, like vitamin D from sheep's wool. However, this product is made with vitamin D from lichen, a vegan source.

This multivitamin formula also includes many vitamins and minerals that vegans may struggle to get enough of through diet alone, including vitamin B12, vitamin D, iodine, and zinc,

 along with several antioxidants, alpha lipoic acid, inositol, and coenzyme Q10 (CoQ10). CoQ10 is an important factor in energy production processes that support heart health and cellular function, and may be helpful for hormonal balance in women with PCOS.

Power by Naturals products are third-party tested to ensure they're free of microbes and heavy metals. The company provides certificates of analysis (the third-party lab reports for every batch of product) on request. However, our research found that this supplement has an odor that’s strong enough to find unpleasant.

Best Budget-Friendly

Life Extension Two-Per-Day Multivitamin

$13.78 at Target
$14.25Now 3% Off
Buy on Target $13.78

Pros

  • Most affordable on our list
  • Contains inositol and alpha lipoic acid
  • Third-party tested

Cons

  • Dose must be split throughout the day
  • Should be taken with food

Key Specs

  • Form: Capsule or tablet
  • Serving size: 2 capsules or tablets
  • Third-party tested: Yes
  • Dietary considerations: Soy-free, gluten-free, non-GMO
Life Extension Two-Per-Day Multivitamin, available in tablets or capsules, is one of the most affordable methylated multivitamins. In addition to methylated folate, this multivitamin includes inositol and alpha lipoic acid, which may support hormone balance and overall wellness. It also contains mixed tocopherols, compounds closely related to vitamin E, which animal studies have shown may play a role in balancing estrogen levels to prevent or inhibit breast cancer growth.

Life Extension products are third-party tested by ConsumerLab, and ConsumerLab has top rated this product 11 times, most recently in 2024. Two-Per-Day Multivitamin isn't vegan because it contains vitamin D from wool. One potential inconvenience: The daily dose must be divided into two half doses, and each capsule should be taken with food to boost absorption and minimize potential digestive side effects like stomach pain and bloating.

Best Gummy

Nordic Naturals Zero Sugar Multivitamin

$23.76 at Walmart
Buy on Walmart $23.76

Pros

  • Gummy form for those who dislike pills
  • Fruity, flavorful
  • Has 0 grams of sugar
  • Third-party tested
  • Non-GMO

Cons

  • Does not contain methylated folate
  • Fewer nutrients than other products on our list

Key Specs

  • Form: Gummy
  • Serving size: 2 gummies
  • Third-party tested: Yes
  • Dietary considerations: Vegetarian, non-GMO

Nordic Naturals Zero Sugar Multivitamin gummies are a good fit for people who have trouble swallowing pills or who find that the taste or smell of multivitamin capsules is difficult to tolerate. The gummies are a passionfruit mango flavor and are sweetened with stevia and the sugar alcohols sorbitol and maltitol, which provide 0 calories and 0 grams of sugar.

Our research found that customers enjoy the taste and texture of these gummies. While they're vegetarian, they are not vegan because they contain vitamin D from sheep's wool. Nordic Naturals products are all third-party tested to ensure that the supplements are safe, effective, and free from potentially harmful contaminants.

One drawback of gummy vitamins is that they don't contain as many active ingredients as other vitamins. This gummy has much lower amounts of vitamins than many other multivitamins, and the folate in this supplement isn't methylated — it's in the form of folic acid. Also, this gummy contains no minerals except sodium, so you may want to consider adding a mineral supplement if you choose this product. Plus, stevia and sugar alcohols may cause gastrointestinal issues like bloating and gas in some people.

Comparison Table

Best For
Form
Serving Size
Third-Party Tested
FullWell Women's Multivitamin
Hormonal Health
Capsule
3 capsules
Yes
Buy Now $49.95
Pure Encapsulations O.N.E. Multivitamin
Once Daily
Capsule
1 capsule
Yes
Buy Now $45.20
Perelel Prenatal Packs
Prenatal
Capsule and softgel
1 pack contains 4 or 5 capsules
Yes
Buy Now $55.34
Trace Liquid Multi Vitamin- Mineral
Liquid
Liquid
2 tablespoons
Yes
Buy Now $37.79
Rainbow Light Women's One Multivitamin
Women Over 50
Tablet
1 tablet
No
Buy Now $11.69
Metagenics PhytoMulti With Iron
Iron
Tablet
2 tablets
Yes
Buy Now $39.15
Power by Naturals Methyl Multi One
Vegan
Capsule
1 capsule
Yes
Buy Now $35.95
Life Extension Two-Per-Day Multivitamin
Budget-Friendly
Capsule or tablet
2 capsules or tablets
Yes
Buy Now $13.78
Nordic Naturals Zero Sugar Multivitamin
Gummy
Gummy
2 gummies
Yes
Buy Now $23.76

How We Chose the Best Methylated Multivitamins for Women

There's not a lot of research on methylated nutrients for MTHFR gene mutations, so it was important that we carefully consider existing evidence and speak with dietitians when choosing the best methylated multivitamins.

For this piece, we spoke to three registered dietitians:

We prioritized products with quality third-party testing. We included tablet, capsule, liquid, and gummy options at a variety of price points, so most people are able to find a suitable choice in our recommendations.

Additionally, I’m a registered dietitian, and I've also completed DNA testing and learned that I have an MTHFR gene mutation. Even though research findings are mixed about the benefits, I prefer methylated B vitamins for everyday use and methylated prenatals when I'm pregnant or nursing. My personal and professional experience helped when choosing products and compiling the information about the methylated multivitamins in this guide.

What to Look for When Buying Methylated Multivitamins for Women

These are the most important considerations when choosing a methylated multivitamin:

  • Nutrient Forms Check the label to ensure the supplement you're considering contains methylated forms of vitamin B12 and folic acid. Check the supplement facts label for folate from MTHF or 5-MTHF and vitamin B12 from methylcobalamin.
  • Third-Party Testing Supplements don't need quality testing before they can be sold in the United States.

     Unfortunately, this means that many supplements don't contain what they claim or may contain contaminants like heavy metals or undisclosed allergens. Third-party testing or certifications from organizations like the National Sanitation Foundation (NSF), Informed Choice, United States Pharmacopeia (USP), or ConsumerLab can help you feel confident that the supplement you choose is safe and effective.
  • Form Most multivitamins are available as capsules or tablets, but there are liquid and gummy forms for people who dislike or can't swallow pills.
  • Price Methylated multivitamins can range in price from about $0.30 per serving to $1.75 per serving. Choose one that fits comfortably in your budget, especially if you plan to take a multivitamin for a long time.

What Are the Benefits of Methylated Multivitamins for Women?

"Using a methylated multivitamin helps bypass that bottleneck," says Peterson, of Goodyear, Arizona. Methylated nutrients — folate, in particular — play a role in the metabolism of S-adenosyl-L-methionine (SAM-e), which is vital for several functions across the body and in every single cell.

 However, there are numerous possible MTHFR gene mutations, all of which may cause your body to respond differently to methylated and nonmethylated nutrients.
Researchers have also found that an MTHFR variant can lead to increased levels of homocysteine in the blood. Homocysteine is an intermediary compound that may contribute to a variety of issues if your body isn't able to efficiently convert it to methionine, which is then used to manufacture SAM-e. "Methylated B vitamins also play a key role in reducing homocysteine levels, which supports heart health," says Best. "People with fatigue, anxiety, or neurological symptoms may notice improvements when switching to methylated forms."

 Reversing folate and B12 deficiencies can help lower homocysteine levels and support overall health.

Do I Need to Take Methylated Vitamins?

If you have an MTHFR gene variant, you can still get enough folate and vitamin B12 through your diet. Folate is found in beef liver, green vegetables, black-eyed peas, and rice, and vitamin B12 is found in meat, eggs, and milk. Vegans and vegetarians should supplement with B12, but both methylated and nonmethylated forms appear to be helpful for improving the vitamin's level.

Pregnant women should take a prenatal vitamin that contains 400 mcg of folate to help prevent spinal cord defects in infants. However, research shows that supplementation with folic acid — a nonmethylated, synthetic form of folate — can still be helpful for pregnant women. According to the Centers for Disease Control and Prevention, everyone is able to utilize folic acid if they take enough of it, regardless of MTHFR status.

Frequently Asked Questions

Who should take methylated vitamins?
Methylated vitamins may be helpful for people with MTHFR gene mutations. However, existing research doesn't show a clear benefit to these nutrients over other forms. Still, many people with MTHFR prefer methylated vitamins to ensure better absorption and utilization.
Like other multivitamins, methylated multivitamins may cause digestive side effects like stomach pain, nausea, gas, or bloating. Taking multivitamins with food may alleviate some of these side effects, but if they persist or if you experience any other notable side effects, you should stop taking the supplement and consult with your doctor.
The only way to know for sure is to take a DNA test to determine if you have any MTHFR gene variants. Your doctor can help you start this process. There are many online services for DNA testing as well.

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SaVanna is a registered dietitian and health writer.

As a registered dietitan, SaVanna has worked with pregnant and postpartum women, infants and children, people with chronic kidney disease, and people who are critically ill. She is particularly interested in culinary and functional nutrition for weight loss and female hormone health.

She's currently a contributor for Forbes Vetted, Sports Illustrated Showcase, Mashable, and Carb Manager, and her work has also appeared in Greatist, mindbodygreen, and Bicycling Magazine, among other outlets.

SaVanna lives with her husband and three kids in Little Rock, Arkansas. She enjoys cooking, baking, gardening, and weightlifting.

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