Is It Cellulitis or Something Else?
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Is It Cellulitis or Something Else?

Is It Cellulitis or Something Else?
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Updated on June 23, 2025
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You’ve noticed that the skin on one or both of your legs has become swollen and reddened, and it’s spreading. Perhaps it is also painful or rashlike, or you see a sore.

You wouldn’t be blamed for thinking you might have cellulitis, a common bacterial infection affecting the soft tissue, particularly the dermis, fat, and other structures below your top layer of skin.

But you might be wrong.

“Cellulitis is often overdiagnosed or misdiagnosed, and there are many conditions which can mimic it,” says Rachel Bystritsky, MD, an infectious disease specialist at UCSF Health in San Francisco. The areas of redness, swelling, and discomfort that can characterize cellulitis are also features of a number of other maladies, not all of which are caused by infections.

How to Identify Cellulitis

Cellulitis is most often caused by the staphylococcus or streptococcus bacteria.

 It is typically treated with oral antibiotics, says Edidiong C. Kaminska, MD, a Chicago-based dermatologist.

“Usually there is a crack or break in the skin that allows bacteria to enter into it,” says Dr. Kaminska. “The most common location for cellulitis is the lower legs, but it can occur on any part of the body, including the face.”

If the cellulitis is severe, treatment may require intravenous antibiotics or surgical drainage of abscesses (pockets of pus).

Cellulitis is diagnosed by physical examination and taking a medical history, after which blood tests for bacterial infection may be ordered to rule out other conditions.

While there are several conditions that can mimic cellulitis, there are distinguishing factors. For instance, because cellulitis starts as a local infection, it usually affects only one side of the body.

“One really good way to determine if someone may or may not have cellulitis is that if the problem is in both legs, it is unlikely to be cellulitis,” says Kaminska.

In addition, if antibiotics aren’t clearing up a case of suspected cellulitis, other conditions may need to be considered.

How Does Cellulitis Differ From Erysipelas?

Cellulitis is very similar to another bacterial skin infection called erysipelas, which is also known as St. Anthony’s fire. While cellulitis generally infects the skin’s deeper layers and fat, erysipelas affects the skin’s uppermost layers, including the epidermis, as well as the lymph vessels.

Erysipelas is usually caused by group A streptococcus bacteria, and it occurs when there is a break in the skin or problems with blood vessels or lymph system drainage. The infection can affect the legs and arms as well as the face or elsewhere on the body.

The area of redness is usually more clearly defined than with cellulitis, and it may involve blisters or red streaking if the infection has spread along the lymph vessels. Pus is less likely to form with erysipelas. Fever and chills are more common with erysipelas than they are with cellulitis. The condition can permanently damage lymph vessels, leading to chronic swelling in a limb.

Like cellulitis, erysipelas is treated with oral antibiotics or, if the infection is severe, intravenous antibiotics.

Stasis Dermatitis vs. Cellulitis

When there is poor blood flow in the lower legs due to malfunctioning valves in the veins (venous insufficiency), the result can be another common mimic of cellulitis: stasis dermatitis.

“It usually appears as redness,” says Kaminska. “The skin could be swollen, tender, and rashy on the legs.” She adds that stasis dermatitis is typically bilateral (affecting both legs), a telltale sign that it is not cellulitis.

With stasis dermatitis, fluid and blood cells can leak out of the vessels into the skin and other tissues, leading to itching, inflammation, and even open sores.

 Swelling around the ankles, discolored skin, and varicose veins can be early signs of the condition and should be reported to your doctor before your skin gets worse.

Chronic venous insufficiency can lead to a condition known as lipodermatosclerosis, or sclerosing panniculitis.

 “It is an inflammation of the underlying fat that can cause the skin to be hard and red and also mimics cellulitis,” says Kaminska. The legs may take on an inverted bowling pin shape. Treatments can include compression therapy, pain relievers, and anti-inflammatories.

Shingles Can Mimic Cellulitis

Herpes zoster, the viral infection also known as shingles, can be mistaken for cellulitis. Shingles is caused by the varicella-zoster virus, which also causes chickenpox. After the initial infection of chickenpox, the virus remains in your body and can reactivate decades later, causing symptoms.

“Sometimes early shingles can look just like a red rash,” says Dr. Bystritsky.

Pain from shingles, known as postherpetic neuralgia, can linger for weeks, months, or even years. If shingles has affected an eye, it can result in temporary or permanent vision loss. There is no cure for shingles, but a vaccine can prevent it or lessen the severity of symptoms. In addition, antiviral medication may help to shorten the shingles attack if you seek medical attention as soon as symptoms appear.

Other early symptoms of shingles can include itching, burning sensations, and shooting pains, usually on one side of the body or face. Later, the rash may develop into small blisters that scab over in 7 to 10 days.

Contact Dermatitis

Sometimes symptoms that look and feel like cellulitis are the result of your skin being irritated by something that it has touched, a condition known as contact dermatitis.

“The area tends to be itchy, also swollen,” says Kaminska. “There may be some blisters. The symptoms are usually limited to the site of contact.” The reaction may be allergic or simply a reaction to irritating substances or friction. While cellulitis typically feels warm and painful, contact dermatitis feels intensely itchy without surrounding warmth.

Potential irritants are numerous and may include hair dyes, fragrances, rubber gloves, fabrics, topical antibiotics, sunscreens, acids, alkaline substances (such as soaps, detergents, fabric softeners, and solvents), or other chemicals. The reaction usually occurs 24 to 48 hours after contact. Treatments vary but could include the use of anti-itch lotions, topical steroids, or simply doing nothing other than removing the irritant or source of allergen.

Differentiating between contact dermatitis and cellulitis is important because the medication used to treat one condition might impede the healing process of the other.

Deep Vein Thrombosis

If a blood clot forms within a vein deep inside of a leg, arm, or the pelvis, the condition is known as deep vein thrombosis (DVT).

“Deep vein thrombosis can also look a lot like cellulitis of the leg,” says Bystritsky. Both conditions involve skin that is swollen, reddened, painful, and hot to the touch.

 But the way they are treated is very different. In the case of DVT, a person may be prescribed a blood thinner to prevent blood clots from getting bigger. They may also wear a compression garment on the affected limb to improve blood flow and decrease the chance of complications from blood clots.

It is vital to distinguish this condition from cellulitis: If a blood clot generating the DVT breaks off and travels to a lung and causes a pulmonary embolism, the result can be life-threatening.

Lymphedema and Cellulitis

The relationship between cellulitis and lymphedema (swelling caused when damage to the lymph system prevents the fluid from draining properly) is complicated: Chronic cellulitis can damage the lymph system, leading to lymphedema in an arm or leg.

 On the other hand, lymphedema is a risk factor for cellulitis because it makes the skin more vulnerable to infection.

The symptoms of redness, swelling, and hardening of the skin that can accompany lymphedema can also be mistaken for cellulitis.

 And the two conditions can coexist.
If there are no symptoms of systemic infection or warmth in the affected area, a doctor may conclude that the problem is more likely to be lymphedema than cellulitis.

 Lymphedema can be treated with compression garments, bandages, manual lymph drainage (a massage-like technique), and sometimes surgery.

Insect Bite Hypersensitivity

“If someone has an exuberant reaction to an insect bite, where it gets really red and swollen and painful, that can mimic cellulitis,” says Kaminska. The reaction is also known as papular urticaria. Mosquito and flea bites are common causes, and children tend to have these reactions more often than adults because of their more sensitive immune systems.

Intense itching can occur, and reddish plaques can form, lasting days to weeks. Antihistamines and topical steroids may be prescribed to treat it.

The Takeaway

  • Cellulitis starts as a bacterial infection, and symptoms include an area on your skin that’s swollen, red, warm, and painful on one side of your body.
  • Cellulitis may be mistaken for other conditions like stasis dermatitis or contact dermatitis. But because other conditions can cause similar symptoms, it’s important to receive a correct diagnosis in order to get proper treatment.
  • It is vital to differentiate cellulitis from conditions like shingles, a viral infection, or deep vein thrombosis, which can have serious effects if not treated correctly.
  • If you suspect you have cellulitis, seek medical attention. This condition is typically treated with antibiotics.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  5. Erysipelas. MedlinePlus. October 13, 2024.
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  10. Geist RS et al. Lipodermatosclerosis. StatPearls. July 21, 2023.
  11. Klejtman T et al. Specific Management of Lipodermatosclerosis (Sclerotic Hypodermitis) in Acute and Chronic Phase. Journal de Medecine Vasculaire. October 2022.
  12. Shingles. MedlinePlus. April 20, 2024.
  13. Contact Dermatitis. MedlinePlus. July 1, 2023.
  14. Bersier D et al. Cellulitis and Deep Vein Thrombosis: A Controversial Association. Journal of Thrombosis and Haemostasis. April 2003.
  15. Deep Vein Thrombosis: Diagnosis and Treatment. Mayo Clinic. June 11, 2022.
  16. Deep Vein Thrombosis and Pulmonary Embolism. Centers for Disease Control and Prevention. April 23, 2025.
  17. Al-Niaimi F et al. Cellulitis and Lymphoedema: A Vicious Cycle. Wounds International. February 14, 2014.
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Jacquelyn Dosal

Jacquelyn Dosal, MD

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Jacquelyn Dosal, MD, is a board-certified dermatologist practicing at The Dermatology House in Park City, Utah. Her areas of expertise include acne, rosacea, integrative treatments of inflammatory skin diseases, as well as laser treatment of the skin and injectables.

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