Cellulitis Causes, Risk Factors, and Prevention

While cellulitis isn’t always preventable, understanding its causes and risk factors may lower your chances of becoming infected and help you to know when it’s time to seek medical care.
Common Causes of Cellulitis
What Raises Your Risk?
A Weak Immune System
Some people develop infections easily because their immune systems aren’t strong enough to protect them from bacteria and other germs. Children and the elderly typically have weaker immune systems and are at greater risk of cellulitis than young and middle-aged adults.
Certain medical conditions also weaken the immune system. These include diabetes, cancer, HIV, and autoimmune diseases like lupus or rheumatoid arthritis.
A History of Skin Problems
You can also get cellulitis when another skin condition causes a break in your skin. These include athlete’s foot, contact dermatitis, atopic dermatitis, shingles, and chickenpox.
Being Obese or Overweight
Lymphedema
Lymphedema in the legs can also occur as a result of cancer treatment, injury to the lymph nodes or lymph vessels in the legs, or certain infections.
Injection Drug Use
Cellulitis Prevention Tips
Protect Your Skin From Injury
Here’s how you can prevent skin injuries:
- Apply sunscreen and insect repellent when spending time outdoors.
- Don’t pick at or scratch your skin.
- Keep your fingernails trimmed to help prevent scratching.
- Follow your doctor’s orders for treating eczema and other rashes or skin conditions.
- Learn to use knives and other sharp tools properly.
- Avoid burns when cooking by using hot pads to handle hot pots and pans, and wear gloves when washing dishes.
- For construction and DIY projects, or when using hazardous chemicals, wear protective gloves, boots, and safety goggles.
- When playing sports, wear appropriate protective gear.
- Don’t walk around barefoot, especially outdoors — and especially if you have diabetes.
- Don’t attempt “bathroom surgery” on calluses or corns.
Treat Wounds Promptly and Properly
“Wounds should be cleaned with soap and water, covered with a thin layer of an antibiotic ointment, and then covered with a bandage,” says Amesh A. Adalja, MD, a board-certified infectious disease physician in Pittsburgh and a senior scholar and assistant professor at the Johns Hopkins University Center for Health Security in Baltimore.
“People with wounds should avoid exposure to fresh water, dirt, and the like, and wounds should be inspected daily to check for signs of infection, which could include redness, drainage, and swelling,” Dr. Adalja adds.
Monitor wounds and look for any signs of infection. If your symptoms get worse rather than better, progress quickly, or become severe, go to the emergency department, says Tsippora Shainhouse, MD, a board-certified dermatologist at SkinSafe Dermatology and Skin Care in Beverly Hills, California, and a clinical instructor at the University of Southern California.
“Regular reassessment of the skin by a healthcare provider is critical for appropriate management,” Dr. Shainhouse notes.
Wash Your Hands Regularly
Dry your hands with a clean towel and apply moisturizer to your hands and skin on a regular basis. This can prevent skin dryness and cracking.
Make Healthy Lifestyle Changes
Obesity or being overweight can increase the risk for cellulitis, so take steps toward maintaining a healthy weight by limiting your intake of sugar and fast food, eating plenty of unprocessed fruits and vegetables, and increasing your daily physical activity.
The Takeaway
- Cellulitis is a deep bacterial infection of the skin that causes redness, swelling, and tenderness.
- Risk factors for cellulitis include being obese, having a weakened immune system, and lymphedema, a potential complication of breast cancer treatment.
- Good hygiene and skin care, and quickly treating any breaks in the skin can help prevent cellulitis.
- Untreated cellulitis can get worse quickly and potentially cause severe complications; if you develop signs or symptoms of cellulitis, see a doctor right away.
Common Questions & Answers
- Cellulitis. Mayo Clinic. May 16, 2025.
- Cellulitis: Who Gets and Causes. American Academy of Dermatology.
- Cellulitis. Johns Hopkins Medicine.
- Impetigo. Mayo Clinic. April 19, 2023.
- Cellulitis: How to Prevent It From Returning. American Academy of Dermatology.
- Deivert SF et al. Obesity and the Immune System. Obesity Action Coalition. Winter 2013.
- Lymphedema. Mayo Clinic. November 24, 2022.
- Chambers HF. Skin and Soft Tissue Infections in Persons Who Inject Drugs. Infectious Disease Clinics of North America. March 2021.
- Should You Bandage a Cut or Sore or Let It Air Out? Cleveland Clinic. March 10, 2021.
- About Handwashing. Centers for Disease Control and Prevention. February 16, 2024.

Allison Buttarazzi, MD
Medical Reviewer
Allison Buttarazzi, MD, is board-certified in internal medicine and lifestyle medicine, and is a certified health and well-being coach. In her primary care practice, Dr. Buttarazzi focuses on lifestyle medicine to help her patients improve their health and longevity, and her passion is helping patients prevent and reverse chronic diseases (like heart disease, high blood pressure, and diabetes) by improving their lifestyle habits.
She is a graduate of Tufts University School of Medicine and completed a residency at Maine Medical Center. Diagnosed with celiac disease during medical school, she realized the power of improving one's health through diet and lifestyle habits, which she later incorporated into her practice.
