Cellulitis Causes, Risk Factors, and Prevention

Cellulitis Causes, Risk Factors, and Prevention

Cellulitis Causes, Risk Factors, and Prevention
Getty Images
Cellulitis is a potentially serious bacterial infection that develops in the deep layers of the skin below the epidermis. Signs and symptoms of cellulitis include swelling, redness, pain, and tenderness in the affected area. Some people also develop blisters, chills, fevers, and nausea.

If cellulitis goes untreated, the infection can get into the bloodstream and become life-threatening.

While cellulitis isn’t always preventable, understanding its causes and risk factors may lower your chances of becoming infected and help you to know when it’s time to seek medical care.

Common Causes of Cellulitis

Most cases of cellulitis are caused by staphylococcus (staph) and streptococcus (strep) bacteria. Both can live harmlessly on intact skin, but when the skin is broken, the result can be a bacterial infection of its top or deeper layers.

Typically, cellulitis starts with a minor scratch, cut, abrasion, bug bite, or other skin injury. Taking care of these injuries promptly can prevent infection.

What Raises Your Risk?

Certain conditions raise the risk of cellulitis and other skin infections. These include:

A Weak Immune System

Some people develop infections easily because their immune systems aren’t strong enough to protect them from bacteria and other germs. Children and the elderly typically have weaker immune systems and are at greater risk of cellulitis than young and middle-aged adults.

Certain medical conditions also weaken the immune system. These include diabetes, cancer, HIV, and autoimmune diseases like lupus or rheumatoid arthritis.

Taking an immunosuppressant drug also lowers your body’s ability to fight off invaders.

Corticosteroid drugs can have a similar effect.

A History of Skin Problems

Cellulitis can be a complication of impetigo, a bacterial skin infection of the top layer of skin. Impetigo causes small bumps or blisters that rupture and form crusty scabs. Treatment involves taking oral or topical antibiotics.

You can also get cellulitis when another skin condition causes a break in your skin. These include athlete’s foot, contact dermatitis, atopic dermatitis, shingles, and chickenpox.

Frequent skin injuries due to occupational or recreational activities also raise the risk for cellulitis.

In some cases, a doctor may recommend a continuous low-dose antibiotic to prevent recurrent episodes of cellulitis because having one bout of it increases your chances of another infection.

Being Obese or Overweight

Excess weight puts you at risk for cellulitis because being overweight can make it harder for the body to fight infections.

Obesity or being overweight also increases the risk of developing lymphedema — another cellulitis risk factor — after cancer or cancer treatment.

Lymphedema

Fluid buildup in the arms and legs, called lymphedema, increases the risk for cellulitis. A common cause of lymphedema in the arms is the removal of lymph nodes between the breast and underarm during treatment for breast cancer.

Lymphedema in the legs can also occur as a result of cancer treatment, injury to the lymph nodes or lymph vessels in the legs, or certain infections.

Injection Drug Use

Research indicates that skin infections, including cellulitis, are common among injection drug users, particularly when users — rather than injecting into a vein — inject directly into skin or muscle tissue.

 Use of unsterilized needles and inadequate skin cleansing before injection also raises the risk of infection.

Cellulitis Prevention Tips

There are several steps you can take to prevent cellulitis from occurring in the first place or to prevent recurrent infections:

Protect Your Skin From Injury

Here’s how you can prevent skin injuries:

  • Apply sunscreen and insect repellent when spending time outdoors.
  • Don’t pick at or scratch your skin.
  • Keep your fingernails trimmed to help prevent scratching.
  • Follow your doctor’s orders for treating eczema and other rashes or skin conditions.
  • Learn to use knives and other sharp tools properly.
  • Avoid burns when cooking by using hot pads to handle hot pots and pans, and wear gloves when washing dishes.
  • For construction and DIY projects, or when using hazardous chemicals, wear protective gloves, boots, and safety goggles.
  • When playing sports, wear appropriate protective gear.
  • Don’t walk around barefoot, especially outdoors — and especially if you have diabetes.
  • Don’t attempt “bathroom surgery” on calluses or corns.

Treat Wounds Promptly and Properly

“Wounds should be cleaned with soap and water, covered with a thin layer of an antibiotic ointment, and then covered with a bandage,” says Amesh A. Adalja, MD, a board-certified infectious disease physician in Pittsburgh and a senior scholar and assistant professor at the Johns Hopkins University Center for Health Security in Baltimore.

“People with wounds should avoid exposure to fresh water, dirt, and the like, and wounds should be inspected daily to check for signs of infection, which could include redness, drainage, and swelling,” Dr. Adalja adds.

Most skin injuries heal best when covered with gauze or an adhesive bandage that keeps the wound surface moist, but not wet.

Monitor wounds and look for any signs of infection. If your symptoms get worse rather than better, progress quickly, or become severe, go to the emergency department, says Tsippora Shainhouse, MD, a board-certified dermatologist at SkinSafe Dermatology and Skin Care in Beverly Hills, California, and a clinical instructor at the University of Southern California.

“Regular reassessment of the skin by a healthcare provider is critical for appropriate management,” Dr. Shainhouse notes.

Wash Your Hands Regularly

Regularly washing your hands can stop the spread of some bacterial infections. Wash your hands for at least 20 seconds — the amount of time it takes to sing the “Happy Birthday” song twice.

Dry your hands with a clean towel and apply moisturizer to your hands and skin on a regular basis. This can prevent skin dryness and cracking.

Make Healthy Lifestyle Changes

Obesity or being overweight can increase the risk for cellulitis, so take steps toward maintaining a healthy weight by limiting your intake of sugar and fast food, eating plenty of unprocessed fruits and vegetables, and increasing your daily physical activity.

Stop smoking if you smoke, and limit your intake of alcohol to no more than one drink per day for women and no more than two drinks per day for men. Both smoking and heavy drinking can increase the risk of cellulitis.

The Takeaway

  • Cellulitis is a deep bacterial infection of the skin that causes redness, swelling, and tenderness.
  • Risk factors for cellulitis include being obese, having a weakened immune system, and lymphedema, a potential complication of breast cancer treatment.
  • Good hygiene and skin care, and quickly treating any breaks in the skin can help prevent cellulitis.
  • Untreated cellulitis can get worse quickly and potentially cause severe complications; if you develop signs or symptoms of cellulitis, see a doctor right away.

Common Questions & Answers

What are the signs and symptoms of cellulitis?
Signs and symptoms of cellulitis include swelling, redness, pain, tenderness, blisters, chills, fevers, and nausea.
The most common cause of cellulitis is a bacterial infection from staphylococcus and streptococcus bacteria. These bacteria can infect the skin when it’s broken, such as from a scratch or cut.
Risk factors for cellulitis include having a weakened immune system, a history of skin problems, obesity or being overweight, having lymphedema, and using illicit injectable drugs.
To prevent cellulitis, you should protect your skin from injury, treat wounds promptly and properly, wash your hands regularly, and make healthy lifestyle changes, such as losing weight, quitting smoking, and limiting alcohol intake.
Cellulitis is treatable with antibiotics. It is important to see a doctor right away if you develop signs or symptoms of cellulitis to prevent the infection from becoming life-threatening.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Cellulitis. Mayo Clinic. May 16, 2025.
  2. Cellulitis: Who Gets and Causes. American Academy of Dermatology.
  3. Cellulitis. Johns Hopkins Medicine.
  4. Impetigo. Mayo Clinic. April 19, 2023.
  5. Cellulitis: How to Prevent It From Returning. American Academy of Dermatology.
  6. Deivert SF et al. Obesity and the Immune System. Obesity Action Coalition. Winter 2013.
  7. Lymphedema. Mayo Clinic. November 24, 2022.
  8. Chambers HF. Skin and Soft Tissue Infections in Persons Who Inject Drugs. Infectious Disease Clinics of North America. March 2021.
  9. Should You Bandage a Cut or Sore or Let It Air Out? Cleveland Clinic. March 10, 2021.
  10. About Handwashing. Centers for Disease Control and Prevention. February 16, 2024.
Allison Buttarazzi, MD

Allison Buttarazzi, MD

Medical Reviewer

Allison Buttarazzi, MD, is board-certified in internal medicine and lifestyle medicine, and is a certified health and well-being coach. In her primary care practice, Dr. Buttarazzi focuses on lifestyle medicine to help her patients improve their health and longevity, and her passion is helping patients prevent and reverse chronic diseases (like heart disease, high blood pressure, and diabetes) by improving their lifestyle habits.

She is a graduate of Tufts University School of Medicine and completed a residency at Maine Medical Center. Diagnosed with celiac disease during medical school, she realized the power of improving one's health through diet and lifestyle habits, which she later incorporated into her practice.

Valencia Higuera

Valencia Higuera

Author
Valencia Higuera is a writer and digital creator from Chesapeake, Virginia. As a personal finance and health junkie, she enjoys all things related to budgeting, saving money, fitness, and healthy living. In addition to Everyday Health, Higuera has written for various publications, including Healthline, GOBankingRates, MyBankTracker, and The Mortgage Reports.