How Long Does It Take Adderall and Other ADHD Medications to Work?

The Timing of ADHD Meds

If you've decided to try ADHD medication for yourself or your child, you may be wondering how long it takes to kick in. Here's what experts say.
The Timing of ADHD Meds
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Amphetamine- and methylphenidate-based drugs are the first-choice medications used for treating many people with attention deficit hyperactivity disorder (ADHD). They are available in a generic iteration and under brand names such as Adderall, Ritalin, Concerta, and Focalin. In their immediate-release forms they’re typically effective within an hour while the timed-release versions take about 12 hours.

There are additional treatment options, like nonstimulant medications for patients who cannot tolerate the approved stimulants. Talk therapy is also another approach used to manage the condition.

ADHD can affect individuals differently, and your healthcare provider can help you find a suitable option.

Stimulant Medications for ADHD

Despite the name, stimulants don’t actually increase stimulation in people with ADHD. Instead, they increase the levels of the brain chemicals dopamine and norepinephrine. Stimulants have been found to be an effective form of treatment for managing symptoms for about 70 percent of people with ADHD.

Stimulants can help you:

  • Pay attention
  • Reduce distraction and impulsivity
  • Stay motivated
According to the Cleveland Clinic, how quickly a drug works and how long it lasts will depend partially on whether the stimulant is a short acting or long acting.

Short-Acting Stimulants for ADHD

Short-acting or immediate-release stimulants are formulated to be released into the body rapidly and wear off quickly, most usually lasting up to four hours.

As the effects of the medication diminish, some individuals experience “rebound,” a sudden drop in energy levels, severe hunger and low or depressed mood. Still, short-acting stimulants can be helpful if you need a medication boost or need help quickly.

Here are some examples of short-acting stimulants for ADHD, along with the time they take to kick in and how long their effects last.

Generic name
Brand name/s
How Soon You’ll Feel The effect
How long they last
dexmethylphenidate hydrochloride
Focalin
30 to 45 minutes
Up to 6 hours
methylphenidate hydrochloride

Methylin chewable

Methylin oral solution

Ritalin

30 minutes to 1 hour
2.5 to 4 hours

dextroamphetamine mixed salt and amphetamine

Adderall
30 to 45 minutes
4 to 6 hours

methamphetamine hydrochloride

Desoxyn
30 to 45 minutes
3 to 4 hours
amphetamine sulfate

Evekeo

Evekeo ODT

30 to 45 minutes
3 to 4 hours
dextroamphetamine sulfate

Zenzedi

Dexedrine

30 to 45 minutes

30 minutes to 1 hour

3 to 4 hours

4 to 6 hours

Long-Acting Stimulants for ADHD

The effects of long-acting stimulants can be more subtle than those of short-acting stimulants, but you'll feel the effects for a longer period of time. Despite containing the same amount of active ingredients as a short-acting medication, extended-release tablets are formulated to release some of their contents immediately and the rest after a few hours. This should result in a more consistent and longer-lasting effect.

Here are examples of long-acting ADHD stimulant medications, along with the times they take to work and how long they last.

Generic name
Brand name/s
How Soon You’ll Feel The effect
How long they last
methylphenidate hydrochloride
Adhansia extended release (XR)
Within an hour
16 hours

serdexmethylphenidate/

dexmethylphenidate

Azstarys
about 30 minutes
12 to 13 hours

methylphenidate hydrochloride

Aptensio XR

Concerta

Within an hour
12 hours

methamphetamine hydrochloride

Desoxyn
30 to 45 minutes
3 to 4 hours
methylphenidate

Contempla XR ODT

Daytrana patch

Within an hour

Within 2 hours

3 to 4 hours
dexmethylphenidate hydrochloride
Focalin XR

First peak effect 1.5 hours

Second peak effect 6.5

8 to 10 hours

methylphenidate hydrochloride

Jornay PM

Metadate CD

Metadate ER

Methylin ER

Quillichew ER

Ritalin-SR

Ritalin LA

8 to 10 hours

First 4 hours

about 2 hours

about 45 minutes

22 to 24 hours (10 to 12 hours after delayed onset)

Up to 12 hours

8 hours

8 hours

Up to 8 hours

8 hours

8 hours

dextroamphetamine sulfate

dextroamphetamine sulfate (oral solution)

Dexedrine Spansule

Dexedrine

ProCentra

30 minutes

Immediate

Immediate

6 to 9 hours

4 to 6 hours

amphetamine
Dyanavel XR
1 hour
13 hours
amphetamine and dextroamphetamine mixed salts
Mydayis
2 to 4 hours
Up to 16 hours
lisdexamfetamine dimesylate

Vyvanse chewable

Vyvanse

2 hours
Up to 12 hours

Nonstimulant ADHD Medication

While stimulants are effective for some people with ADHD, they have one major drawback: They are controlled drugs with the potential for dependence and misuse. Alternatively, nonstimulant medications are available. These are not controlled drugs and do not pose the same risk of dependence.

For some people, they're a useful long-term option. They help to manage ADHD by increasing norepinephrine levels. Your healthcare provider may prescribe a nonstimulant medication along with a stimulant ADHD drug to increase the efficacy of the stimulant.

For some people, they're a useful long-term option. They help to manage ADHD by increasing norepinephrine levels. Your healthcare provider may prescribe a nonstimulant medication along with a stimulant ADHD drug to increase the efficacy of the stimulant.

Nonstimulants can help improve:

  • Reduced distraction
  • Executive functioning (better able to manage daily tasks)
  • Impulsive behavior
Nonstimulants can take longer to show noticeable effects, typically two to four weeks after regular use. Nonetheless, the effects can last longer than those of stimulant drugs, up to 24 hours.

Here are some nonstimulants your healthcare provider might suggest.

Generic name
Brand name/s
How Soon You’ll Feel The effect
How long they last
atomoxetine
Strattera
2 to 8 weeks
24 hours
viloxazine
Qelbree
2 to 8 weeks
24 hours

clonidine ER

Kapvay
2 to 8 weeks
Up to 24 hours

guanfacine ER

Intuniv
2 to 4 weeks
12 to 24 hours

How to Tell if ADHD Medication Is Working

Not all ADHD drugs suit everyone, and finding the proper medication and dosage may be a case of trial and error. Your healthcare provider will work with you to find a suitable option. Here are some tips to help you decide if medications are working.

Observation and Self-Awareness

Start by asking yourself or those around you if you are or seem to be:

  • Focusing more than before
  • Staying on task better
  • Better able to sit still
  • Listening to others more carefully
  • Less prone to impulsive behavior

Keep a Journal

Keeping a journal can help you track any changes over time. Make a list of behaviors you’d like to work on and note if there’s any change. For instance, how many minutes can you sit still without needing to get up and walk around? Ask for feedback from loved ones and friends, and include their comments in your journal.

Know What to Expect From Your Meds

Medications can differ in their effects, and individual reactions may vary. Not all changes are immediate and significant especially when using non stimulants. Keep an eye out for the following:

  • Immediate changes: You may notice improvements from the first day.
  • Subtle changes: Some shifts may occur that are not obvious.
  • Delayed changes: Certain medications take time to work, with gradual changes in brain chemistry leading to long-term, positive results.

If you’re unsure there are improvements, consult your healthcare provider. They may ask you to continue with the drug a little longer, or they may change your dose or medication type. Finding the most suitable treatment can take time, but each approach will help you get closer to your goal.

Side Effects of ADHD Medication

ADHD medications can have adverse effects, depending on factors such as the drug type and the individual using it.

Stimulant Drugs

While not everyone will experience adverse effects, research suggests the following can occur:

  • Elevated blood pressure and heart rate
  • Anxiety and irritability in some people
  • Possible risk of dependence and misuse
  • Gastrointestinal issues, such as heartburn, constipation, bloating, nausea, and vomiting
  • Decreased appetite, potentially leading to unintended weight loss
  • Abdominal pain
  • Psychosis
  • Cardiac disease
  • Blurred vision and red or dry eyes
  • Difficulty sleeping
  • Headaches
  • Mood changes
  • Slower bone growth, usually resolving over time

Following your healthcare provider’s  instructions when using these drugs can help reduce the risk of severe effects, such as misuse. They can also help address other unwanted effects, possibly by changing the dose or medication.

Nonstimulant Drugs

Nonstimulant drugs can also produce a range of adverse effects, such as:

  • Fatigue
  • Dry mouth
  • Nausea
  • Vomiting
  • Low appetite
  • Gastrointestinal symptoms, such as diarrhea or constipation
  • Abdominal pain
  • Irritability
  • Fatigue
  • Difficulty sleeping
  • Changes in heart rate or blood pressure
  • A rash
  • Mood changes

Generally, these side effects are common with nonstimulant medications, but certain drugs will also have specific adverse effects. It's vital to speak with a healthcare provider about potential side effects and review the information provided in the drug package before taking any medication.

The Takeaway

For many people, certain medications are effective in managing the symptoms of ADHD. A wide range of options are available, including stimulant and nonstimulant drugs.

Some medications provide almost instant relief, while others take longer but may lead to more subtle, long-term changes. The choice will depend partially on the individual and their needs. Working with a healthcare provider can help you work toward what’s best for you.

EDITORIAL SOURCES
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Resources
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  2. ADHD Medication. Cleveland Clinic.
  3. Boorady R. Stimulant Medications for ADHD. Child Mind Institute.
  4. Nanda N et al. Adverse Effects of Stimulant Interventions for Attention Deficit Hyperactivity Disorder (ADHD): A Comprehensive Systematic Review. Cureus. September 26, 2023.
  5. Guanfacine. MedlinePlus.
  6. Clonidine Hydrochloride Tablet, Extended Release. National Library of Medicine.
  7. Qelbree. Supernus Pharmaceuticals.
  8. Atomoxetine. MedlinePlus.